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Effect of high levels of human chorionic gonadotropin and estradiol on the severity of hyperemesis gravidarum
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Peng Chiong Tan
Veröffentlicht/Copyright:
1. Februar 2009
Abstract
Background: Serum human chorionic gonadotropin (hCG) and estradiol levels are higher in women with hyperemesis gravidarum (HG) than in unaffected pregnant controls. We postulated that higher levels of these hormones may be associated with clinically more severe HG. The aim of this study was to evaluate the effect of maternal hCG and estradiol levels on the severity of HG.
Methods: A prospective study was performed on 167 first trimester women hospitalized for HG. Venous blood was taken for hCG and estradiol levels. Scattergrams were plotted for hCG or estradiol levels vs. gestational age. A curve of best fit was drawn. Women were categorized into two groups according to their position above or below the curve. Prolonged hospital stay (≥4 days) was used as a marker for HG severity. Multivariable logistic regression analysis was used to control for differences in characteristics, laboratory results on admission, and treatment received.
Results: After adjustment, high hCG level adjusted odds ratio (AOR) (2.2, 95% CI 1.0–4.9, p=0.04) and hyponatremia AOR (2.8, 95% CI 1.2–6.6, p=0.02) were independently associated with prolonged hospital stay. With bivariate analysis, high estradiol level was not associated with prolonged stay.
Conclusions: High hCG but not estradiol is associated with more severe HG.
Clin Chem Lab Med 2009;47:165–71.
Received: 2008-8-12
Accepted: 2008-10-27
Published Online: 2009-02-01
Published in Print: 2009-02-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
estradiol;
hospital stay;
human chorionic gonadotropin;
hyperemesis gravidarum
Artikel in diesem Heft
- Editorial
- 50th Anniversary of SBCC/BVKC: “International Symposium Brussels 2008: New Trends in Clinical Biology. Emerging Technologies and their Impact on Laboratory Medicine and Management”
- Reviews
- Vitamin D: current status and perspectives
- Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?
- New European guidelines for cardiovascular disease prevention in clinical practice
- Review
- Causes, consequences, detection, and prevention of identification errors in laboratory diagnostics
- Genetics and Molecular Diagnostics
- The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan
- Polymorphisms and plasma soluble levels of E-selectin in patients with chronic hepatitis B virus infection
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- Performance of free β-human chorionic gonadotrophin (free β-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands
- A pilot survey of the use and implementation of cardiac markers in acute coronary syndrome and heart failure across Europe The CARdiac MArker Guideline Uptake in Europe (CARMAGUE) study
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