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Thyroid-related autoantibodies in Tunisian patients with coeliac disease
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Dorsaf Toumi
Published/Copyright:
March 1, 2008
Abstract
Background: The aim of our study was to evaluate, retrospectively, the frequency of anti-thyroid antibodies (ATA) in coeliac disease (CD) patients.
Methods: ELISA was used to determine the frequency of anti-thyroid stimulating hormone receptor antibodies, thyroperoxidase antibodies and thyroglobulin antibodies in sera of 104 adult patients with CD. Patients were divided into three groups: group I, 56 untreated patients; group II, 21 patients on a strict gluten-free diet (GFD); and group III, 27 patients who did not comply with a GFD. Sera of 189 healthy blood donors served as controls.
Results: Out of 104 patients with CD, five (4.8%) had ATA. The frequency of ATA found in the control group (1.6%) was not significantly different from that found in all CD patients. However, the frequency of ATA in CD patients on a GFD was significantly higher than that found in the control group (8.3% vs. 1.6%, p=0.03). The frequency of ATA in groups I, II and III was 1.8%, 9.5% and 7.4%, respectively.
Conclusions: ATA were found in CD patients even on a GFD.
Clin Chem Lab Med 2008;46:350–3.
Keywords: anti-thyroid stimulating hormone receptor antibodies; coeliac disease; thyroglobulin antibodies; thyroperoxidase antibodies
Received: 2007-8-29
Accepted: 2007-11-29
Published Online: 2008-03-01
Published in Print: 2008-03-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
anti-thyroid stimulating hormone receptor antibodies;
coeliac disease;
thyroglobulin antibodies;
thyroperoxidase antibodies
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