Article
Licensed
Unlicensed
Requires Authentication
Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease
-
Yen-Hung Lin
Published/Copyright:
January 1, 2008
Abstract
Background: Obesity and homocysteine are important risk factors for cardiovascular disease. The relation between pattern of obesity and homocysteine is unclear. The objective of this study was to investigate the relation between pattern of obesity and plasma total homocysteine (tHcy) level in male patients with coronary artery disease (CAD).
Methods: A total of 63 male patients (mean age 66.2 years) with angiographically documented CAD were enrolled. Overnight fasting blood samples were measured for plasma tHcy, serum folic acid and serum vitamin B12 levels. Anthropometric measurements included waist-to-hip ratio (WHR) and body mass index (BMI).
Results: The mean WHR was 0.90±0.05, mean BMI 24.6±3.3 kg/m2 and the mean plasma tHcy level 11.6±3.2 μmol/L. In univariate analysis, plasma tHcy level correlated significantly with serum vitamin B12 level, serum folic acid level, WHR, estimated creatinine clearance, aspirin use and fibrate use. There was no significant association between plasma tHcy level and BMI. In multivariate analysis, only WHR (β-value 22.263, p<0.001), serum level of vitamin B12 (β-value –0.004, p=0.003), estimated creatinine clearance (β-value –4.154, p=0.003) and use of fibrates (β-value 2.307, p=0.031) were independent predictors of plasma tHcy level.
Conclusions: WHR, but not BMI, is a strong independent predictor of plasma tHcy level in male patients with CAD.
Clin Chem Lab Med 2008;46:125–30.
Keywords: body mass index (BMI); coronary artery disease (CAD); homocysteine; waist-to-hip ratio (WHR)
Received: 2007-3-22
Accepted: 2007-9-10
Published Online: 2008-01-01
Published in Print: 2008-01-01
©2008 by Walter de Gruyter Berlin New York
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Editorial
- Improving healthcare through advances in point-of-care technologies
- Review
- New creatinine sensor for point-of-care testing of creatinine meets the National Kidney Disease Education Program guidelines
- Original Papers
- Performance of a multi-profile critical care testing analyzer
- Comparative study of calculated and measured total carbon dioxide
- Letter to the Editor
- Performance of immunofluorometric point-of-care assays for free pregnancy-associated plasma protein A detection in whole blood samples
- Guidelines and Recommendations
- IFCC Guideline for sampling, measuring and reporting ionized magnesium in plasma
- Reviews
- Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics
- The entero-insular axis: implications for human metabolism
- Genetics and Molecular Diagnostics
- Functional polymorphisms in the promoter of the matrix metalloproteinase-9 (MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects
- Genetic profiling in healthy subjects from the Stanislas cohort based on 24 polymorphisms: effects on biological variables
- Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians
- Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT –13907C>G, LCT –13910C>T and LCT –13915T>G with Pyrosequencing™ technology
- A new high-throughput screening method for the detection of chronic lymphatic leukemia and myelodysplastic syndrome
- General Clinical Chemistry and Laboratory Medicine
- Saliva analysis by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS): from sample collection to data analysis
- Mechanism of sodium loss with muscle sodium deficiency in sodium supplemented and unsupplemented subjects during hypokinesia
- Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer
- Lipid peroxidation in stroke patients
- Resistin is present in human breast milk and it correlates with maternal hormonal status and serum level of C-reactive protein
- Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease
- Isoenzymes of N-acetyl-β-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study
- The in vivo and in vitro effects of L-carnitine supplementation on the erythrocyte membrane acetylcholinesterase, Na+, K+-ATPase and Mg2+-ATPase activities in basketball players
- Validation and Outcome Studies
- Analytical evaluation of the Optium Xido blood glucose meter
- Letters to the Editor
- New biomarkers of myocardial injury and assessment of cardiac toxicity during preparative regimen and hematopoietic cell transplantation in acute leukemia
- Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome
Keywords for this article
body mass index (BMI);
coronary artery disease (CAD);
homocysteine;
waist-to-hip ratio (WHR)
Articles in the same Issue
- Editorial
- Improving healthcare through advances in point-of-care technologies
- Review
- New creatinine sensor for point-of-care testing of creatinine meets the National Kidney Disease Education Program guidelines
- Original Papers
- Performance of a multi-profile critical care testing analyzer
- Comparative study of calculated and measured total carbon dioxide
- Letter to the Editor
- Performance of immunofluorometric point-of-care assays for free pregnancy-associated plasma protein A detection in whole blood samples
- Guidelines and Recommendations
- IFCC Guideline for sampling, measuring and reporting ionized magnesium in plasma
- Reviews
- Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics
- The entero-insular axis: implications for human metabolism
- Genetics and Molecular Diagnostics
- Functional polymorphisms in the promoter of the matrix metalloproteinase-9 (MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects
- Genetic profiling in healthy subjects from the Stanislas cohort based on 24 polymorphisms: effects on biological variables
- Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians
- Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT –13907C>G, LCT –13910C>T and LCT –13915T>G with Pyrosequencing™ technology
- A new high-throughput screening method for the detection of chronic lymphatic leukemia and myelodysplastic syndrome
- General Clinical Chemistry and Laboratory Medicine
- Saliva analysis by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS): from sample collection to data analysis
- Mechanism of sodium loss with muscle sodium deficiency in sodium supplemented and unsupplemented subjects during hypokinesia
- Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer
- Lipid peroxidation in stroke patients
- Resistin is present in human breast milk and it correlates with maternal hormonal status and serum level of C-reactive protein
- Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease
- Isoenzymes of N-acetyl-β-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study
- The in vivo and in vitro effects of L-carnitine supplementation on the erythrocyte membrane acetylcholinesterase, Na+, K+-ATPase and Mg2+-ATPase activities in basketball players
- Validation and Outcome Studies
- Analytical evaluation of the Optium Xido blood glucose meter
- Letters to the Editor
- New biomarkers of myocardial injury and assessment of cardiac toxicity during preparative regimen and hematopoietic cell transplantation in acute leukemia
- Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome
