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Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics

  • Mika Ala-Korpela
Published/Copyright: November 18, 2007
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Clinical Chemistry and Laboratory Medicine
From the journal Clinical Chemistry and Laboratory Medicine Volume 46 Issue 1

Abstract

This review focuses on (i) the current status of 1H NMR spectroscopy to quantify lipoprotein subclasses directly from serum or plasma, and (ii) the applications of 1H NMR metabonomics of serum in biomedicine. Related to both themes, experimental and data analysis methodologies are discussed together with the biochemical rationales. Particular emphasis is placed on the concepts of risk assessment and diagnostics in relation to the potential clinical role of 1H NMR metabonomics; recent applications in the area of coronary heart disease and diabetes are addressed in more detail.

Clin Chem Lab Med 2008;46:27–42.

Keywords: blood plasma and serum; coronary heart disease; data analysis; diagnostics; lipoprotein subclass; metabolomics; metabonomics; nuclear magnetic resonance spectroscopy; quantification; risk assessment
Corresponding author: Dr. Mika Ala-Korpela, PhD in Physics, Docent in Biological NMR, Group Leader in Computational Medicine, Laboratory of Computational Engineering, Systems Biology and Bioinformation Technology, Helsinki University of Technology, P.O. Box 9203, 02015 HUT Finland Phone: +358-50-3535457, Fax: +358-9-4514833,
Received: 2007-7-5
Accepted: 2007-8-6
Published Online: 2007-11-18
Published in Print: 2008-01-01

©2008 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/CCLM.2008.006
Keywords for this article
blood plasma and serum; coronary heart disease; data analysis; diagnostics; lipoprotein subclass; metabolomics; metabonomics; nuclear magnetic resonance spectroscopy; quantification; risk assessment

Articles in the same Issue

  1. Editorial
  2. Improving healthcare through advances in point-of-care technologies
  3. Review
  4. New creatinine sensor for point-of-care testing of creatinine meets the National Kidney Disease Education Program guidelines
  5. Original Papers
  6. Performance of a multi-profile critical care testing analyzer
  7. Comparative study of calculated and measured total carbon dioxide
  8. Letter to the Editor
  9. Performance of immunofluorometric point-of-care assays for free pregnancy-associated plasma protein A detection in whole blood samples
  10. Guidelines and Recommendations
  11. IFCC Guideline for sampling, measuring and reporting ionized magnesium in plasma
  12. Reviews
  13. Critical evaluation of 1H NMR metabonomics of serum as a methodology for disease risk assessment and diagnostics
  14. The entero-insular axis: implications for human metabolism
  15. Genetics and Molecular Diagnostics
  16. Functional polymorphisms in the promoter of the matrix metalloproteinase-9 (MMP-9) gene are not linked with significant plasma MMP-9 variations in healthy subjects
  17. Genetic profiling in healthy subjects from the Stanislas cohort based on 24 polymorphisms: effects on biological variables
  18. Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians
  19. Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT –13907C>G, LCT –13910C>T and LCT –13915T>G with Pyrosequencing™ technology
  20. A new high-throughput screening method for the detection of chronic lymphatic leukemia and myelodysplastic syndrome
  21. General Clinical Chemistry and Laboratory Medicine
  22. Saliva analysis by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF/MS): from sample collection to data analysis
  23. Mechanism of sodium loss with muscle sodium deficiency in sodium supplemented and unsupplemented subjects during hypokinesia
  24. Increased levels of 8-hydroxydeoxyguanosine and its relationship with lipid peroxidation and antioxidant vitamins in lung cancer
  25. Lipid peroxidation in stroke patients
  26. Resistin is present in human breast milk and it correlates with maternal hormonal status and serum level of C-reactive protein
  27. Waist-to-hip ratio correlates with homocysteine levels in male patients with coronary artery disease
  28. Isoenzymes of N-acetyl-β-hexosaminidase in human pleomorphic adenoma and healthy salivary glands: a preliminary study
  29. The in vivo and in vitro effects of L-carnitine supplementation on the erythrocyte membrane acetylcholinesterase, Na+, K+-ATPase and Mg2+-ATPase activities in basketball players
  30. Validation and Outcome Studies
  31. Analytical evaluation of the Optium Xido blood glucose meter
  32. Letters to the Editor
  33. New biomarkers of myocardial injury and assessment of cardiac toxicity during preparative regimen and hematopoietic cell transplantation in acute leukemia
  34. Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome
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