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Carbonyl Stress and Diabetic Complications

  • Toshio Miyata , Naoyoshi Ishikawa and Charles van Ypersele de Strihou
Published/Copyright: June 1, 2005
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 41 Issue 9

Abstract

Advanced glycation irreversibly and progressively modifies proteins over time and yields the advanced glycation end-products (AGE). AGEs are thought to contribute to the development of atherosclerosis and of diabetic and uremic complications. Their inhibition has thus become a therapeutic goal. In this article, we discuss the role of various reactive carbonyl compound (RCOs) in the genesis of AGEs, postulate the existence of “carbonyl stress” in complicated diabetes and, finally, discuss therapeutic perspectives.

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Published Online: 2005-06-01
Published in Print: 2003-09-16

Copyright © 2003 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Editors' Introduction: Welcome to the Special Issue on Diabetes Mellitus
  2. Linking Research and Innovative Clinical Practice: The Story of Diabetes Mellitus
  3. Insulin Resistant States and Insulin Signaling
  4. Diabesity: An Inflammatory Metabolic Condition
  5. Plasma Adiponectin and Hyperglycaemia in Diabetic Patients
  6. Platelet Function and Acetyl-Coenzyme A Metabolism in Type 1 Diabetes Mellitus
  7. Oxidative Stress in Diabetes
  8. Carbonyl Stress and Diabetic Complications
  9. Chemical Modification of Proteins by Lipids in Diabetes
  10. Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method
  11. Dyslipidemia in Patients with Type 2 Diabetes. Relationships between Lipids, Kidney Disease and Cardiovascular Disease
  12. Haemoglobin A1c – A Marker for Complications of Type 2 Diabetes: The Experience from the UK Prospective Diabetes Study (UKPDS)
  13. Glycated Hemoglobin Standardization – National Glycohemoglobin Standardization Program (NGSP) Perspective
  14. Haemoglobin A1c: Analysis and Standardisation
  15. Point-of-Care Testing in Diabetes Mellitus
  16. Evaluation of Portable Blood Glucose Meters. Problems and Recommendations
  17. Measurements of Glucose on the Skin Surface, in Stratum Corneum and in Transcutaneous Extracts: Implications for Physiological Sampling
  18. Biological Variability of Albumin Excretion Rate and Albumin-to-Creatinine Ratio in Hypertensive Type 2 Diabetic Patients
  19. Clinical and Laboratory Evaluation of Specific Chemiluminescence Assays for Intact and Total Proinsulin
  20. Clinical Impact of the New Criteria for the Diagnosis of Diabetes Mellitus
  21. The Effect of the New ADA and WHO Guidelines on the Number of Diagnosed Cases of Diabetes Mellitus
  22. Detecting Type 2 Diabetes by a Single Post-Challenge Blood Sample
  23. Laboratory Tests in Diagnosis and Management of Diabetes Mellitus. Practical Considerations
  24. Obesity, Glucose Intolerance and Diabetes and Their Links to Cardiovascular Disease. Implications for Laboratory Medicine
  25. Meetings and Awards
https://doi.org/10.1515/CCLM.2003.178

Articles in the same Issue

  1. Editors' Introduction: Welcome to the Special Issue on Diabetes Mellitus
  2. Linking Research and Innovative Clinical Practice: The Story of Diabetes Mellitus
  3. Insulin Resistant States and Insulin Signaling
  4. Diabesity: An Inflammatory Metabolic Condition
  5. Plasma Adiponectin and Hyperglycaemia in Diabetic Patients
  6. Platelet Function and Acetyl-Coenzyme A Metabolism in Type 1 Diabetes Mellitus
  7. Oxidative Stress in Diabetes
  8. Carbonyl Stress and Diabetic Complications
  9. Chemical Modification of Proteins by Lipids in Diabetes
  10. Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method
  11. Dyslipidemia in Patients with Type 2 Diabetes. Relationships between Lipids, Kidney Disease and Cardiovascular Disease
  12. Haemoglobin A1c – A Marker for Complications of Type 2 Diabetes: The Experience from the UK Prospective Diabetes Study (UKPDS)
  13. Glycated Hemoglobin Standardization – National Glycohemoglobin Standardization Program (NGSP) Perspective
  14. Haemoglobin A1c: Analysis and Standardisation
  15. Point-of-Care Testing in Diabetes Mellitus
  16. Evaluation of Portable Blood Glucose Meters. Problems and Recommendations
  17. Measurements of Glucose on the Skin Surface, in Stratum Corneum and in Transcutaneous Extracts: Implications for Physiological Sampling
  18. Biological Variability of Albumin Excretion Rate and Albumin-to-Creatinine Ratio in Hypertensive Type 2 Diabetic Patients
  19. Clinical and Laboratory Evaluation of Specific Chemiluminescence Assays for Intact and Total Proinsulin
  20. Clinical Impact of the New Criteria for the Diagnosis of Diabetes Mellitus
  21. The Effect of the New ADA and WHO Guidelines on the Number of Diagnosed Cases of Diabetes Mellitus
  22. Detecting Type 2 Diabetes by a Single Post-Challenge Blood Sample
  23. Laboratory Tests in Diagnosis and Management of Diabetes Mellitus. Practical Considerations
  24. Obesity, Glucose Intolerance and Diabetes and Their Links to Cardiovascular Disease. Implications for Laboratory Medicine
  25. Meetings and Awards
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