Linking Research and Innovative Clinical Practice: The Story of Diabetes Mellitus
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Marek H. Dominiczak
Abstract
Research into diabetes mellitus and the clinical practice of diabetology are a fascinating illustration how the accumulation of knowledge leads to changing scientific theories and paradigms. The pivotal point in the history of diabetes, the discovery of insulin and its introduction to treatment, was one of the most spectacular events in medicine. Later, diabetes care provided, among other developments, models for multidisciplinary approach to treatment and the blueprint for community-based epidemiological studies. The history of diabetology also illustrates the role of chemistry, and later laboratory medicine, in the management of disease.
This article is an introduction to the special issue of Clinical Chemistry and Laboratory Medicine, focused on diabetes mellitus and its complications.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Editors' Introduction: Welcome to the Special Issue on Diabetes Mellitus
- Linking Research and Innovative Clinical Practice: The Story of Diabetes Mellitus
- Insulin Resistant States and Insulin Signaling
- Diabesity: An Inflammatory Metabolic Condition
- Plasma Adiponectin and Hyperglycaemia in Diabetic Patients
- Platelet Function and Acetyl-Coenzyme A Metabolism in Type 1 Diabetes Mellitus
- Oxidative Stress in Diabetes
- Carbonyl Stress and Diabetic Complications
- Chemical Modification of Proteins by Lipids in Diabetes
- Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method
- Dyslipidemia in Patients with Type 2 Diabetes. Relationships between Lipids, Kidney Disease and Cardiovascular Disease
- Haemoglobin A1c – A Marker for Complications of Type 2 Diabetes: The Experience from the UK Prospective Diabetes Study (UKPDS)
- Glycated Hemoglobin Standardization – National Glycohemoglobin Standardization Program (NGSP) Perspective
- Haemoglobin A1c: Analysis and Standardisation
- Point-of-Care Testing in Diabetes Mellitus
- Evaluation of Portable Blood Glucose Meters. Problems and Recommendations
- Measurements of Glucose on the Skin Surface, in Stratum Corneum and in Transcutaneous Extracts: Implications for Physiological Sampling
- Biological Variability of Albumin Excretion Rate and Albumin-to-Creatinine Ratio in Hypertensive Type 2 Diabetic Patients
- Clinical and Laboratory Evaluation of Specific Chemiluminescence Assays for Intact and Total Proinsulin
- Clinical Impact of the New Criteria for the Diagnosis of Diabetes Mellitus
- The Effect of the New ADA and WHO Guidelines on the Number of Diagnosed Cases of Diabetes Mellitus
- Detecting Type 2 Diabetes by a Single Post-Challenge Blood Sample
- Laboratory Tests in Diagnosis and Management of Diabetes Mellitus. Practical Considerations
- Obesity, Glucose Intolerance and Diabetes and Their Links to Cardiovascular Disease. Implications for Laboratory Medicine
- Meetings and Awards
Articles in the same Issue
- Editors' Introduction: Welcome to the Special Issue on Diabetes Mellitus
- Linking Research and Innovative Clinical Practice: The Story of Diabetes Mellitus
- Insulin Resistant States and Insulin Signaling
- Diabesity: An Inflammatory Metabolic Condition
- Plasma Adiponectin and Hyperglycaemia in Diabetic Patients
- Platelet Function and Acetyl-Coenzyme A Metabolism in Type 1 Diabetes Mellitus
- Oxidative Stress in Diabetes
- Carbonyl Stress and Diabetic Complications
- Chemical Modification of Proteins by Lipids in Diabetes
- Glyoxal and Methylglyoxal Levels in Diabetic Patients: Quantitative Determination by a New GC/MS Method
- Dyslipidemia in Patients with Type 2 Diabetes. Relationships between Lipids, Kidney Disease and Cardiovascular Disease
- Haemoglobin A1c – A Marker for Complications of Type 2 Diabetes: The Experience from the UK Prospective Diabetes Study (UKPDS)
- Glycated Hemoglobin Standardization – National Glycohemoglobin Standardization Program (NGSP) Perspective
- Haemoglobin A1c: Analysis and Standardisation
- Point-of-Care Testing in Diabetes Mellitus
- Evaluation of Portable Blood Glucose Meters. Problems and Recommendations
- Measurements of Glucose on the Skin Surface, in Stratum Corneum and in Transcutaneous Extracts: Implications for Physiological Sampling
- Biological Variability of Albumin Excretion Rate and Albumin-to-Creatinine Ratio in Hypertensive Type 2 Diabetic Patients
- Clinical and Laboratory Evaluation of Specific Chemiluminescence Assays for Intact and Total Proinsulin
- Clinical Impact of the New Criteria for the Diagnosis of Diabetes Mellitus
- The Effect of the New ADA and WHO Guidelines on the Number of Diagnosed Cases of Diabetes Mellitus
- Detecting Type 2 Diabetes by a Single Post-Challenge Blood Sample
- Laboratory Tests in Diagnosis and Management of Diabetes Mellitus. Practical Considerations
- Obesity, Glucose Intolerance and Diabetes and Their Links to Cardiovascular Disease. Implications for Laboratory Medicine
- Meetings and Awards