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Anti-Phospholipid Antibodies in Diabetes Mellitus

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 40 Issue 6

Abstract

The presence of autoantibodies to phospholipids may be associated with various pathological disorders; diabetes could be one of them because of the changes occurring in lipid metabolism but there are only few reports examining this question, and they are not always leading to the same conclusions because of the differences in the procedures or in the phospholipids tested. We carried out a systematic comparative study of diabetic serum antibody binding to all phospholipids, anionic and zwitterionic, by a quantitative ELISA. The implication of the hydrophobic moiety of the lipids was also studied: the presence of autoantibodies to the fatty acyl chains was investigated. Our results show the presence of anti-phospholipid antibodies in diabetic sera, particularly anti-phosphatidylinositol and anti-phosphatidylcholine which have never been tested before, and appear to be associated with macroangiopathic complications. The antigenic epitopes are mainly the polar heads as no antibody binding to the hydrophobic moiety was observed. We discuss the relation of those antibodies to the angiopathic complications and to the direct effects of hyperglycemia on lipid antigenicity.

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Published Online: 2005-06-01
Published in Print: 2002-06-21

Copyright (c) 2002 by Walter de Gruyter GmbH & Co. KG

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  1. IFCC Primary Reference Procedures for the Measurement of Catalytic Concentrations of Enzymes – the New Concept
  2. Allele Frequency of the G→T Mutation of the Col1A1 Gene Analyzed by an ARMS-PCR in Osteoporotic Subjects with Femoral Neck Fractures
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  4. Mutation Analysis of the MPZ and PMP22 Genes in Croatian Patients
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  12. Anti-Phospholipid Antibodies in Diabetes Mellitus
  13. Alteration of Serum Enzymes in Primary Hypothyroidism
  14. The Changes of Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Erythrocytes of Active and Passive Smokers
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  19. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 3. Reference Procedure for the Measurement of Catalytic Concentration of Lactate Dehydrogenase
  20. Meetings and Awards
https://doi.org/10.1515/CCLM.2002.104

Articles in the same Issue

  1. IFCC Primary Reference Procedures for the Measurement of Catalytic Concentrations of Enzymes – the New Concept
  2. Allele Frequency of the G→T Mutation of the Col1A1 Gene Analyzed by an ARMS-PCR in Osteoporotic Subjects with Femoral Neck Fractures
  3. Vitamin Supplementation Normalizes Total Plasma Homocysteine Concentration but Not Plasma Homocysteine Redox Status in Patients with Acute Coronary Syndromes and Hyperhomocysteinemia
  4. Mutation Analysis of the MPZ and PMP22 Genes in Croatian Patients
  5. Dynamic Equilibrium between Protein S and C4b Binding Protein Is Important for Accurate Determination of Free Protein S Antigen
  6. Immunoassay of Anti-Thyroid Autoantibodies: High Analytical Variability in Second Generation Methods
  7. The Measurement of Insulin-like Growth Factor-I (IGF-1) Concentration in Random Urine Samples
  8. Urinary Bikunin Determination Provides Insight into Proteinase/Proteinase Inhibitor Imbalance in Patients with Inflammatory Diseases
  9. Breath Markers and Soluble Lipid Peroxidation Markers in Critically Ill Patients
  10. Comparison of Laser-Probe and Photometric Determination of the Urinary Crystallization Risk of Calcium Oxalate
  11. Comparison of First Trimester, Second Trimester and Integrated Downs Syndrome Screening Results in Unaffected Pregnancies
  12. Anti-Phospholipid Antibodies in Diabetes Mellitus
  13. Alteration of Serum Enzymes in Primary Hypothyroidism
  14. The Changes of Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Erythrocytes of Active and Passive Smokers
  15. Internal Quality Control System for Non-Stationary, Non-Ergodic Analytical Processes Based upon Exponentially Weighted Estimation of Process Means and Process Standard Deviation
  16. Evaluation of Commutability of Control Materials
  17. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 1. The Concept of Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes
  18. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 2. Reference Procedure for the Measurement of Catalytic Concentration of Creatine Kinase
  19. IFCC Primary Reference Procedures for the Measurement of Catalytic Activity Concentrations of Enzymes at 37°C. Part 3. Reference Procedure for the Measurement of Catalytic Concentration of Lactate Dehydrogenase
  20. Meetings and Awards
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