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Commutability of Serum Protein Values: Persisting Bias among Manufacturers Using Values Assigned from the Certified Reference Material 470 (CRM 470) in the United States
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Thomas B. Ledue
Veröffentlicht/Copyright:
1. Juni 2005
Abstract
Significant among-manufacturer differences in values for serum proteins persist 7 years after the introduction of the international reference material (Certified Reference Material 470; Reference Preparation for Proteins in Human Serum). In some cases, such as transthyretin and C4, the biases actually continue to increase. Further efforts at standardization are needed in order to improve commutability of results among laboratories and are essential if universal reference intervals are to be developed.
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Published Online: 2005-06-01
Published in Print: 2001-11-26
Copyright © 2001 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- The Present State of Protein Analysis and Interpretation
- In Memoriam Carl-Bertil Laurell
- From Paper Electrophoresis to Computer-supported Interpretation of Capillary Electrophoresis – Clinical Plasma Protein Analysis in Malmö, Sweden
- The Pavia Approach to Clinical Protein Analysis
- How the Foundation for Blood Research (FBR) Has Managed Serum Protein Testing for New England Clinicians
- Evidence-Based Laboratory Interpretation System Built on a Large Collection of Case Records with Well-Defined Diagnoses
- A Knowledge-Based System to Aid with the Clinical Interpretation of Complex Serum Protein Data
- Markers of the Acute Phase Response in Cardiovascular Disease: An Update
- Protein Aggregation
- Protein Standardization I: Protein Purification. Procedure for the Purification of Human Prealbumin, Orosomucoid and Transferrin as Primary Protein Preparations
- Protein Standardization II: Dry Mass Determination. Procedure for the Determination of the Dry Mass of a Pure Protein Preparation
- Protein Standardization III: Method Optimization. Basic Principles for Quantitative Determination of Human Serum Proteins on Automated Instruments Based on Turbidimetry or Nephelometry
- Protein Standardization IV: Value Transfer. Procedure for the Assignment of Serum Protein Values from a Reference Preparation to a Target Material
- Effect of Certified Reference Material 470 (CRM 470) on National Quality Assurance Programs for Serum Proteins in Europe
- Commutability of Serum Protein Values: Persisting Bias among Manufacturers Using Values Assigned from the Certified Reference Material 470 (CRM 470) in the United States
- The Existing Interim Consensus Reference Ranges and the Future Approach
- Using Multiples of the Median to Normalize Serum Protein Measurements
- Strategy for Determining Racial and Environmental Similarities and Differences for Plasma Proteins
- Standardization of Immunoassay for CRM-Related Proteins in Japan: From Evaluating CRM 470 to Setting Reference Intervals
- Soluble Transferrin Receptor (sTfR): Biological Variations and Reference Limits
- High Sensitivity C-Reactive Protein (CRP) Reference Intervals in the Elderly
- High Sensitivity Immunoassays for C-Reactive Protein: Promises and Pitfalls
- Meetings and Awards
Artikel in diesem Heft
- The Present State of Protein Analysis and Interpretation
- In Memoriam Carl-Bertil Laurell
- From Paper Electrophoresis to Computer-supported Interpretation of Capillary Electrophoresis – Clinical Plasma Protein Analysis in Malmö, Sweden
- The Pavia Approach to Clinical Protein Analysis
- How the Foundation for Blood Research (FBR) Has Managed Serum Protein Testing for New England Clinicians
- Evidence-Based Laboratory Interpretation System Built on a Large Collection of Case Records with Well-Defined Diagnoses
- A Knowledge-Based System to Aid with the Clinical Interpretation of Complex Serum Protein Data
- Markers of the Acute Phase Response in Cardiovascular Disease: An Update
- Protein Aggregation
- Protein Standardization I: Protein Purification. Procedure for the Purification of Human Prealbumin, Orosomucoid and Transferrin as Primary Protein Preparations
- Protein Standardization II: Dry Mass Determination. Procedure for the Determination of the Dry Mass of a Pure Protein Preparation
- Protein Standardization III: Method Optimization. Basic Principles for Quantitative Determination of Human Serum Proteins on Automated Instruments Based on Turbidimetry or Nephelometry
- Protein Standardization IV: Value Transfer. Procedure for the Assignment of Serum Protein Values from a Reference Preparation to a Target Material
- Effect of Certified Reference Material 470 (CRM 470) on National Quality Assurance Programs for Serum Proteins in Europe
- Commutability of Serum Protein Values: Persisting Bias among Manufacturers Using Values Assigned from the Certified Reference Material 470 (CRM 470) in the United States
- The Existing Interim Consensus Reference Ranges and the Future Approach
- Using Multiples of the Median to Normalize Serum Protein Measurements
- Strategy for Determining Racial and Environmental Similarities and Differences for Plasma Proteins
- Standardization of Immunoassay for CRM-Related Proteins in Japan: From Evaluating CRM 470 to Setting Reference Intervals
- Soluble Transferrin Receptor (sTfR): Biological Variations and Reference Limits
- High Sensitivity C-Reactive Protein (CRP) Reference Intervals in the Elderly
- High Sensitivity Immunoassays for C-Reactive Protein: Promises and Pitfalls
- Meetings and Awards
