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Strategy for Determining Racial and Environmental Similarities and Differences for Plasma Proteins

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 39 Issue 11

Abstract

The aim of this protocol is to establish a common basis for the production of reference values and well-defined and documented reference intervals for plasma proteins, based on common standardization, using the IFCC/BCR/CAP Certified Reference Material CRM 470. The strategy is to search for racial and environmental/geographical similarities and sources of differences in order to describe the main causes for variability among smaller or larger groups in selected societies and to estimate the sizes of differences for the different proteins according to the investigated sources. For this purpose, groups of reference individuals are selected according to race and geographical/environmental location, e.g. African Americans and Caucasians from the US. The reference individuals are groups of approximately 160 healthy male blood donors, 20 to 60 years of age. Rule-out criteria are positivity for HIV, hepatitis B and C antibodies and blood hemoglobin below the lower reference limit. Exclusion in relation to different C-reactive protein (CRP) levels will be investigated. Coagulation, storage conditions, transport, and the procedure for thawing are specified. The laboratories undertaking the measurements must have adequate analytical performance, and calibration and quality of performance are defined and documented, together with recommended control materials and procedures. Statistical models for describing distributions and for comparing groups are described. It is recommended that the data be presented as reference limits with 90% confidence intervals of those limits.

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Published Online: 2005-06-01
Published in Print: 2001-11-26

Copyright © 2001 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. The Present State of Protein Analysis and Interpretation
  2. In Memoriam Carl-Bertil Laurell
  3. From Paper Electrophoresis to Computer-supported Interpretation of Capillary Electrophoresis – Clinical Plasma Protein Analysis in Malmö, Sweden
  4. The Pavia Approach to Clinical Protein Analysis
  5. How the Foundation for Blood Research (FBR) Has Managed Serum Protein Testing for New England Clinicians
  6. Evidence-Based Laboratory Interpretation System Built on a Large Collection of Case Records with Well-Defined Diagnoses
  7. A Knowledge-Based System to Aid with the Clinical Interpretation of Complex Serum Protein Data
  8. Markers of the Acute Phase Response in Cardiovascular Disease: An Update
  9. Protein Aggregation
  10. Protein Standardization I: Protein Purification. Procedure for the Purification of Human Prealbumin, Orosomucoid and Transferrin as Primary Protein Preparations
  11. Protein Standardization II: Dry Mass Determination. Procedure for the Determination of the Dry Mass of a Pure Protein Preparation
  12. Protein Standardization III: Method Optimization. Basic Principles for Quantitative Determination of Human Serum Proteins on Automated Instruments Based on Turbidimetry or Nephelometry
  13. Protein Standardization IV: Value Transfer. Procedure for the Assignment of Serum Protein Values from a Reference Preparation to a Target Material
  14. Effect of Certified Reference Material 470 (CRM 470) on National Quality Assurance Programs for Serum Proteins in Europe
  15. Commutability of Serum Protein Values: Persisting Bias among Manufacturers Using Values Assigned from the Certified Reference Material 470 (CRM 470) in the United States
  16. The Existing Interim Consensus Reference Ranges and the Future Approach
  17. Using Multiples of the Median to Normalize Serum Protein Measurements
  18. Strategy for Determining Racial and Environmental Similarities and Differences for Plasma Proteins
  19. Standardization of Immunoassay for CRM-Related Proteins in Japan: From Evaluating CRM 470 to Setting Reference Intervals
  20. Soluble Transferrin Receptor (sTfR): Biological Variations and Reference Limits
  21. High Sensitivity C-Reactive Protein (CRP) Reference Intervals in the Elderly
  22. High Sensitivity Immunoassays for C-Reactive Protein: Promises and Pitfalls
  23. Meetings and Awards
https://doi.org/10.1515/CCLM.2001.181

Articles in the same Issue

  1. The Present State of Protein Analysis and Interpretation
  2. In Memoriam Carl-Bertil Laurell
  3. From Paper Electrophoresis to Computer-supported Interpretation of Capillary Electrophoresis – Clinical Plasma Protein Analysis in Malmö, Sweden
  4. The Pavia Approach to Clinical Protein Analysis
  5. How the Foundation for Blood Research (FBR) Has Managed Serum Protein Testing for New England Clinicians
  6. Evidence-Based Laboratory Interpretation System Built on a Large Collection of Case Records with Well-Defined Diagnoses
  7. A Knowledge-Based System to Aid with the Clinical Interpretation of Complex Serum Protein Data
  8. Markers of the Acute Phase Response in Cardiovascular Disease: An Update
  9. Protein Aggregation
  10. Protein Standardization I: Protein Purification. Procedure for the Purification of Human Prealbumin, Orosomucoid and Transferrin as Primary Protein Preparations
  11. Protein Standardization II: Dry Mass Determination. Procedure for the Determination of the Dry Mass of a Pure Protein Preparation
  12. Protein Standardization III: Method Optimization. Basic Principles for Quantitative Determination of Human Serum Proteins on Automated Instruments Based on Turbidimetry or Nephelometry
  13. Protein Standardization IV: Value Transfer. Procedure for the Assignment of Serum Protein Values from a Reference Preparation to a Target Material
  14. Effect of Certified Reference Material 470 (CRM 470) on National Quality Assurance Programs for Serum Proteins in Europe
  15. Commutability of Serum Protein Values: Persisting Bias among Manufacturers Using Values Assigned from the Certified Reference Material 470 (CRM 470) in the United States
  16. The Existing Interim Consensus Reference Ranges and the Future Approach
  17. Using Multiples of the Median to Normalize Serum Protein Measurements
  18. Strategy for Determining Racial and Environmental Similarities and Differences for Plasma Proteins
  19. Standardization of Immunoassay for CRM-Related Proteins in Japan: From Evaluating CRM 470 to Setting Reference Intervals
  20. Soluble Transferrin Receptor (sTfR): Biological Variations and Reference Limits
  21. High Sensitivity C-Reactive Protein (CRP) Reference Intervals in the Elderly
  22. High Sensitivity Immunoassays for C-Reactive Protein: Promises and Pitfalls
  23. Meetings and Awards
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