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Reference Intervals and Variation for Urinary Epinephrine, Norepinephrine and Cortisol in Healthy Men and Women in Denmark

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 39 Issue 9

Abstract

Reference intervals for urinary epinephrine, norepinephrine and cortisol in 120 healthy individuals performing their routine work were established according to the International Union of Pure and Applied Chemistry (IUPAC) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) for use in the risk assessment of exposure to occupational stress. Reference intervals were established for three different times of the day: in morning samples (05.45–07.15) the limit of detection (LOD) was 2.10 μmol epinephrine/mol creatinine (82 women) and 2.86 μmol epinephrine/mol creatinine (37 men), and the reference interval was 3.6–29.1 μmol norepinephrine/mol creatinine and 2.3–52.8 μmol cortisol/mol creatinine (119 women and men); in afternoon samples (15.30–18.30) the reference interval was 0.64–10.8 μmol epinephrine/mol creatinine (82 women), 1.20–11.2 μmol/epinephrine/mol creatinine (36 men), 11.0–54.1 μmol/norepinephrine/mol creatinine and LOD was 42.4 μmol cortisol/mol creatinine (117 women and men); in evening samples (21.45–23.45) LOD was 8.66 μmol epinephrine/mol creatinine (81 women) and 7.99 μmol/epinephrine/mol creatinine (36 men), the reference interval was 11.0–54.1 μmol norepinephrine/mol creatinine, and LOD was 42.4 μmol cortisol/mol creatinine (117 women and men). A variance component model for describing the effects of age, body mass index (BMI), diurnal variation, gender, days of sick leave during past year and smoking habits was established. Women showed a higher morning value but excreted lower amounts of epinephrine during the day as compared to men. No gender differences could be demonstrated for the excretion of norepinephrine and cortisol. Excretion of epinephrine and norepinephrine increased with smoking and decreased with increased BMI. No effects were observed in the excretion of cortisol.

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Published Online: 2005-06-01
Published in Print: 2001-09-07

Copyright © 2001 by Walter de Gruyter GmbH & Co. KG

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  15. Determination of Serum Cystatin C: Biological Variation and Reference Values
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https://doi.org/10.1515/CCLM.2001.140

Articles in the same Issue

  1. Joint Meeting of the German Society of Clinical Chemistry and of the German Society of Laboratory Medicine, Rostock, 1619 September 2001
  2. Herbert Keller January 16, 1925 June 25, 2001
  3. Routine Differential Diagnosis of Proteinurias by Capillary Electrophoresis
  4. Diagnostic Testing in Epstein-Barr Virus Infection
  5. Establishing a Reference System in Clinical Enzymology
  6. Prediction of the Development of Pregnancy-Induced Hypertensive Disorders in High-Risk Pregnant Women by Artificial Neural Networks
  7. Fast Homogeneous Assay for Plasma Procarboxypeptidase U
  8. Detection and Quantification of Small Numbers of Circulating Tumour Cells in Peripheral Blood Using Laser Scanning Cytometer (LSC®)
  9. Monotherapy with Metformin: Does It Improve Hypoxia in Type 2 Diabetic Patients?
  10. Cigarette Smoking and Hypertension Influence Nitric Oxide Release and Plasma Levels of Adhesion Molecules
  11. The Effect of Corticosteroids on Serum and Cerebrospinal Fluid Nitric Oxide Levels in Multiple Sclerosis
  12. Glutathione Transferase P1 Polymorphism in Neuroblastoma Studied by Endonuclease Restriction Mapping
  13. Biological Variation of Interleukin-1β, Interleukin-8 and Tumor Necrosis Factor-α in Serum of Healthy Individuals
  14. Reference Intervals and Variation for Urinary Epinephrine, Norepinephrine and Cortisol in Healthy Men and Women in Denmark
  15. Determination of Serum Cystatin C: Biological Variation and Reference Values
  16. Certification of the Mass Concentration of Creatine Kinase Isoenzyme 2 (CK-MB) in the Reference Material BCR 608
  17. Carbohydrate-Deficient Transferrin (CDT) Determination by Nephelometry Using a Commercial Kit. Analytical and Diagnostic Aspects
  18. Higher CK-MB Mass Values in Heparin Plasma than in Serum Measured with the Abbott AxSYM™ System
  19. Clinical Case Material for Teaching Clinical Chemistry and Laboratory Medicine
  20. IFCC News
  21. Meetings
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