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Glutathione Transferase P1 Polymorphism in Neuroblastoma Studied by Endonuclease Restriction Mapping

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 39 Issue 9

Abstract

Several members of the different glutathione transferase (GST) gene classes are polymorphic. Particular interest has been focused on the GSTP class because this gene class is up-regulated during the early stage of oncogenesis and is significantly overexpressed in many human tumors. It has also been shown that high levels of GSTP1 expression are associated directly with tumor drug resistance and with poor patient survival.

Our aim was to understand the possible association between GSTP1 polymorphism and cellular response to chemotherapeutic drugs in neuroblastoma. In fact, several antineoplastic drugs used in the neuroblastoma high-risk chemotherapeutic protocol are potential substrates of GSTP1-1 (etoposide, adriamycin and carboplatin).

The GSTP1 genotype homozygote *A/*A was identified in 11 patients independent of their response to the chemotherapeutic treatment. Only four patients had a heterozygote genotype A*/B*. Therefore, based on our preliminary data, we were not able to conclude that GSTP1 polymorphism had an impact on patient response to treatment in neuroblastoma.

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Published Online: 2005-06-01
Published in Print: 2001-09-07

Copyright © 2001 by Walter de Gruyter GmbH & Co. KG

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https://doi.org/10.1515/CCLM.2001.138

Articles in the same Issue

  1. Joint Meeting of the German Society of Clinical Chemistry and of the German Society of Laboratory Medicine, Rostock, 1619 September 2001
  2. Herbert Keller January 16, 1925 June 25, 2001
  3. Routine Differential Diagnosis of Proteinurias by Capillary Electrophoresis
  4. Diagnostic Testing in Epstein-Barr Virus Infection
  5. Establishing a Reference System in Clinical Enzymology
  6. Prediction of the Development of Pregnancy-Induced Hypertensive Disorders in High-Risk Pregnant Women by Artificial Neural Networks
  7. Fast Homogeneous Assay for Plasma Procarboxypeptidase U
  8. Detection and Quantification of Small Numbers of Circulating Tumour Cells in Peripheral Blood Using Laser Scanning Cytometer (LSC®)
  9. Monotherapy with Metformin: Does It Improve Hypoxia in Type 2 Diabetic Patients?
  10. Cigarette Smoking and Hypertension Influence Nitric Oxide Release and Plasma Levels of Adhesion Molecules
  11. The Effect of Corticosteroids on Serum and Cerebrospinal Fluid Nitric Oxide Levels in Multiple Sclerosis
  12. Glutathione Transferase P1 Polymorphism in Neuroblastoma Studied by Endonuclease Restriction Mapping
  13. Biological Variation of Interleukin-1β, Interleukin-8 and Tumor Necrosis Factor-α in Serum of Healthy Individuals
  14. Reference Intervals and Variation for Urinary Epinephrine, Norepinephrine and Cortisol in Healthy Men and Women in Denmark
  15. Determination of Serum Cystatin C: Biological Variation and Reference Values
  16. Certification of the Mass Concentration of Creatine Kinase Isoenzyme 2 (CK-MB) in the Reference Material BCR 608
  17. Carbohydrate-Deficient Transferrin (CDT) Determination by Nephelometry Using a Commercial Kit. Analytical and Diagnostic Aspects
  18. Higher CK-MB Mass Values in Heparin Plasma than in Serum Measured with the Abbott AxSYM™ System
  19. Clinical Case Material for Teaching Clinical Chemistry and Laboratory Medicine
  20. IFCC News
  21. Meetings
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