Diagnostic Value of Uric Acid to Differentiate Transudates and Exudates
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Abstract
Uric acid is known to be an end product of purine metabolism. Increases in uric acid may be found in clinical conditions associated with tissue hypoxia. We have investigated the value of uric acid to differentiate between a transudate and exudate. In this study, we measured uric acid in the pleural fluid and the serum of 110 patients, 30 women and 80 men with a mean age of 49.5±19 years. Light's criteria were used to differentiate between a transudate and exudate.
Mean serum uric acid was 496.7±153.4 μmol/l in patients with transudates and 291.3±143.1 μmol/l in patients with exudates. Mean pleural fluid uric acid was 487.7±165 μmol/l in patients with transudates and 279.9±142.1 μmol/l in patients with exudates. These data showed that the levels of serum and pleural uric acid were higher in transudates than exudates (p<0.01). However, there was no significant difference between pleural fluid/serum uric acid ratio of the two patient groups (p>0.05). The specificity and sensitivity of pleural uric acid for diagnosis of transudate effusions were 73% and 80.6%, respectively. The specificity and sensitivity of pleural uric acid for diagnosis of transudate effusions from exudates without malignancy were 71.8% and 91.7%, respectively. The sensitivity and specificity of pleural lactate dehydrogenase for diagnosis of exudates were 82% and 89%; the sensitivity and specificity of pleural fluid/serum lactate dehydrogenase were 85% and 89%; the sensitivity and specificity of pleural fluid/serum protein were 91% and 89%, respectively. Using all three of Light's criteria together, the sensitivity was 91% and its specificity was 94%.
Our findings indicate that determination of uric acid in pleural fluid may be of diagnostic value in differential diagnosis of transudates and exudates. The sensitivity of pleural uric acid measurement was higher for exudates without malignancy. However, Light's criteria remain the best means of separating transudates from exudates.
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
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- SIBioC 2000 32nd National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology
- The Science of Systematic Reviewing Studies of Diagnostic Tests
- Need for Revisiting the Concept of Reference Values
- Purification of Anti-Thyroglobulin IgG from Human Serum
- Preeclampsia Is Associated with Alterations in Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Proteins in Wharton's Jelly of the Umbilical Cord
- Sequential C3 and C4 Levels in Human Milk in Relation to Prematurity and Parity
- Evaluation of Emit® Tox Benzodiazepine and Barbiturate Assays on the Vitalab Viva Analyser and FPIA on the Abbott ADx Analyser
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