Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis
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Abstract
Inflammatory bowel disorders are characterized by an accumulation of eosinophilic granulocytes, mast cells, lymphocytes and neutrophilic granulocytes in the intestinal mucosa. The aim of this study was to examine the concentration of eosinophilic granulocytes in the blood of patients during active ulcerative colitis in comparison with patients during remission and apparently healthy control subjects. Besides counting, the activity grade of eosinophilic granulocytes has been studied by estimation of their degranulation product eosinophil cationic protein.
Subjects with active ulcerative colitis could be distinguished from patients with quiescent ulcerative colitis by establishment of the eosinophil cationic protein concentration, neutrophilic granulocyte count, erythrocyte sedimentation rate, C-reactive protein and albumin concentration.
After two weeks of corticosteroid treatment, serum eosinophil cationic protein concentrations and eosinophil counts in blood were significantly decreased. A decrease in blood eosinophil count was accompanied by a decrease in eosinophil cationic protein concentrations in serum in most subjects with ulcerative colitis. After twelve weeks of corticosteroid administration, serum albumin concentrations were significantly increased, whereas serum concentrations of C-reactive protein were significantly decreased.
During treatment with corticosteroids, serum eosinophil cationic protein concentrations and blood eosinophil counts are appropriate laboratory markers to detect the effect of medication in the course of ulcerative colitis.
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- SIBioC 2000 32nd National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology
- The Science of Systematic Reviewing Studies of Diagnostic Tests
- Need for Revisiting the Concept of Reference Values
- Purification of Anti-Thyroglobulin IgG from Human Serum
- Preeclampsia Is Associated with Alterations in Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Proteins in Wharton's Jelly of the Umbilical Cord
- Sequential C3 and C4 Levels in Human Milk in Relation to Prematurity and Parity
- Evaluation of Emit® Tox Benzodiazepine and Barbiturate Assays on the Vitalab Viva Analyser and FPIA on the Abbott ADx Analyser
- Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis
- Measurement of Purines in Urine by Capillary Electrophoresis for Estimating the Degree of Hypoxia in Infants
- Separation of Erythrocytes into Age-Related Fractions by Density or Size? Counterflow Centrifugation
- Can Age and Sex Related Reference Intervals Be Derived for Non-Healthy and Non-Diseased Individuals from Results of Measurements in Primary Health Care?
- Associations of Apolipoprotein E Concentration and Polymorphism with Lipids and Apolipoprotein Levels in Chinese from Beijing and Shanghai
- Diagnostic Value of Uric Acid to Differentiate Transudates and Exudates
- Evaluation of the Roche Diagnostics LightCycler-Apo B 3500 Mutation Detection Kit
- HIV Infection Does Not Explain Elevation of Glycated Hemoglobin among Non-Diabetic Patients in Gabon
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- Lipoproteins in Health & Disease. By D. J. Betteridge, R. Illingworth and J. Shepherd
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