Can Age and Sex Related Reference Intervals Be Derived for Non-Healthy and Non-Diseased Individuals from Results of Measurements in Primary Health Care?
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Abstract
Reference intervals in clinical chemistry are commonly based on results of measurements in reference populations or are taken from the literature. A reference population should represent a defined group of individuals and be as similar as possible to the patients under investigation. Frequently, reference populations have been recruited from institutionalised healthy young people who do not necessarily fulfill these criteria. In the present study we describe the temporal changes in 37 commonly measured quantities in men and women from childhood to late in life. The samples were collected in the primary health care and sorted according to an assumed decision by the physician. The emerging group of individuals forms a reference population that was regarded as “non-diseased” and the results of measurements in this population are reference values. A remaining group of “non-healthy” were likewise identified for comparison. The central 95 percentile was wider than those usually assigned to the quantities whereas the medians almost coincided. In the “non-healthy” group the medians were shifted in a direction that would be expected from pathophysiology aspects.
Copyright © 2000 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- SIBioC 2000 32nd National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology
- The Science of Systematic Reviewing Studies of Diagnostic Tests
- Need for Revisiting the Concept of Reference Values
- Purification of Anti-Thyroglobulin IgG from Human Serum
- Preeclampsia Is Associated with Alterations in Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Proteins in Wharton's Jelly of the Umbilical Cord
- Sequential C3 and C4 Levels in Human Milk in Relation to Prematurity and Parity
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- Serum Eosinophil Cationic Protein in Active and Quiescent Ulcerative Colitis
- Measurement of Purines in Urine by Capillary Electrophoresis for Estimating the Degree of Hypoxia in Infants
- Separation of Erythrocytes into Age-Related Fractions by Density or Size? Counterflow Centrifugation
- Can Age and Sex Related Reference Intervals Be Derived for Non-Healthy and Non-Diseased Individuals from Results of Measurements in Primary Health Care?
- Associations of Apolipoprotein E Concentration and Polymorphism with Lipids and Apolipoprotein Levels in Chinese from Beijing and Shanghai
- Diagnostic Value of Uric Acid to Differentiate Transudates and Exudates
- Evaluation of the Roche Diagnostics LightCycler-Apo B 3500 Mutation Detection Kit
- HIV Infection Does Not Explain Elevation of Glycated Hemoglobin among Non-Diabetic Patients in Gabon
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- Lipoproteins in Health & Disease. By D. J. Betteridge, R. Illingworth and J. Shepherd
- Viral Hepatitis – Diagnosis, Therapy and Prevention. By Steven Specter, editor
