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Serum Ionized Magnesium: Comparison of Results Obtained with Three Ion-Selective Analyzers

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 37 Issue 4

Abstract

In a two-center (Academic Medical Center, The Netherlands, and National Institutes of Health, USA) study, we compared ionized magnesium (iMg2+) results in serum determined with the AVL 988/4, KONE Microlyte 6 and NOVA CRT, which are the currently available analyzers equipped with a magnesium ion-selective electrode. The comparison was performed with frozen serum samples from normal individuals and patients. Imprecision and reference intervals were established. We found the best agreement between the KONE(x) and AVL(y) magnesium ion-selective electrodes (y = 0.972x−0.013; n = 138) with samples from patients. With samples from normals, all three analyzers reported significantly different results (p < 0.05). Best precision was found using the NOVA; coefficients of variation established at three levels were all < 4.0%. Coefficients of variation for the AVL and KONE were < 5% at normal and high iMg2+, but 10.7 and 9.4%, respectively, at iMg2+ ≈ 0.30 mmol/l. The reference intervals (mean ± standard deviation) based on measurements in fresh serum samples were different for each analyzer: 0.55–0.63 mmol/l for AVL, 0.470.57 mmol/l for KONE and 0.43–0.55 mmol/l for NOVA. Thus, significant differences among the ionized magnesium concentration obtained with the three analyzers, limit comparison of results in clinical practice, and need to be resolved (e.g. by improvement of specificity and standardization of calibrators).

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Published Online: 2005-06-01
Published in Print: 1999-04-01

Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG

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https://doi.org/10.1515/CCLM.1999.075

Articles in the same Issue

  1. Serum Amyloid A (SAA): a Concise Review of Biology, Assay Methods and Clinical Usefulness
  2. Serum Cystatin C as an Endogenous Marker of the Renal Function – a Review
  3. Improved Fluorescent PCR-Based Assay for Sizing CGG Repeats at the FRAXA Locus
  4. The Influence of Radiation and Chemotherapy-Related DNA Strand Breaks on Carcinogenesis: An Evaluation
  5. A Simple HPLC Method for Monitoring Mycophenolic Acid and Its Glucuronidated Metabolite in Transplant Recipients
  6. The Activities of Some Glycosaminoglycan-Degrading Enzymes in the Wall of the Umbilical Cord Artery and Their Alteration in Edema, Proteinuria, Hypertension (EPH)-Gestosis
  7. Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease
  8. Increased Serum Neopterin Concentrations in Patients with Alzheimer’s Disease
  9. Biomarkers of Bone Turnover and Bone Mineral Density in Hyperprolactinemic Amenorrheic Women
  10. Age Relationships and Sex Differences in Serum Levels of Pregnenolone and 17-Hydroxypregnenolone in Normal Subjects
  11. A Study of Hypermagnesaemia in a Hospital Population
  12. Multiple Regression Analysis of Interference Effects from a Hemoglobin-Based Oxygen Carrier Solution
  13. Serum Ionized Magnesium: Comparison of Results Obtained with Three Ion-Selective Analyzers
  14. Automated Prozone Effect Detection in Ferritin Homogeneous Immunoassays Using Neural Network Classifiers
  15. Recent Activities of EC4 in the Harmonization of Clinical Chemistry in the European Union
  16. Preventing Coronary Artery Disease. Cardioprotective Therapeutics in Practice. Edited by M. J. Kendall and R. C. Horton
  17. Will Medical Schools Remain what They Are? Medical Education in the Millennium. Edited by Brian Jolly and Lesley Rees
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