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Increased Serum Neopterin Concentrations in Patients with Alzheimer’s Disease

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Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 37 Issue 4

Abstract

We measured serum neopterin concentrations in 24 patients with Alzheimer's disease (8 males, 16 females; age: 73.1 ± 6.2 years; free of any infectious process) and fourteen controls of similar age (4 males, 10 females; age: 69.7 ± 8.8 years). Compared to controls, significantly higher concentrations of neopterin (p < 0.01) were found in patients with Alzheimer's disease. Among patients, concentrations of neopterin were higher in those with lower mini-mental-state (p < 0.05), and an invers correlation existed between mini-mental-state and neopterin concentrations. No such association existed with the duration of the disease. There were also significant correlations between neopterin and serum concentrations of immune activation markers such as soluble tumor necrosis factor (TNF) receptor and soluble interleukin-2 receptor (all p < 0.01). Thus, increased concentrations of neopterin in serum of patients with Alzheimer's disease correlate with the severity of dementia. The data imply a chronic state of peripheral immune activation in Alzheimer's disease.

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Published Online: 2005-06-01
Published in Print: 1999-04-01

Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Serum Amyloid A (SAA): a Concise Review of Biology, Assay Methods and Clinical Usefulness
  2. Serum Cystatin C as an Endogenous Marker of the Renal Function – a Review
  3. Improved Fluorescent PCR-Based Assay for Sizing CGG Repeats at the FRAXA Locus
  4. The Influence of Radiation and Chemotherapy-Related DNA Strand Breaks on Carcinogenesis: An Evaluation
  5. A Simple HPLC Method for Monitoring Mycophenolic Acid and Its Glucuronidated Metabolite in Transplant Recipients
  6. The Activities of Some Glycosaminoglycan-Degrading Enzymes in the Wall of the Umbilical Cord Artery and Their Alteration in Edema, Proteinuria, Hypertension (EPH)-Gestosis
  7. Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease
  8. Increased Serum Neopterin Concentrations in Patients with Alzheimer’s Disease
  9. Biomarkers of Bone Turnover and Bone Mineral Density in Hyperprolactinemic Amenorrheic Women
  10. Age Relationships and Sex Differences in Serum Levels of Pregnenolone and 17-Hydroxypregnenolone in Normal Subjects
  11. A Study of Hypermagnesaemia in a Hospital Population
  12. Multiple Regression Analysis of Interference Effects from a Hemoglobin-Based Oxygen Carrier Solution
  13. Serum Ionized Magnesium: Comparison of Results Obtained with Three Ion-Selective Analyzers
  14. Automated Prozone Effect Detection in Ferritin Homogeneous Immunoassays Using Neural Network Classifiers
  15. Recent Activities of EC4 in the Harmonization of Clinical Chemistry in the European Union
  16. Preventing Coronary Artery Disease. Cardioprotective Therapeutics in Practice. Edited by M. J. Kendall and R. C. Horton
  17. Will Medical Schools Remain what They Are? Medical Education in the Millennium. Edited by Brian Jolly and Lesley Rees
https://doi.org/10.1515/CCLM.1999.070

Articles in the same Issue

  1. Serum Amyloid A (SAA): a Concise Review of Biology, Assay Methods and Clinical Usefulness
  2. Serum Cystatin C as an Endogenous Marker of the Renal Function – a Review
  3. Improved Fluorescent PCR-Based Assay for Sizing CGG Repeats at the FRAXA Locus
  4. The Influence of Radiation and Chemotherapy-Related DNA Strand Breaks on Carcinogenesis: An Evaluation
  5. A Simple HPLC Method for Monitoring Mycophenolic Acid and Its Glucuronidated Metabolite in Transplant Recipients
  6. The Activities of Some Glycosaminoglycan-Degrading Enzymes in the Wall of the Umbilical Cord Artery and Their Alteration in Edema, Proteinuria, Hypertension (EPH)-Gestosis
  7. Endothelin-1- and Endothelin-Receptors in Lung Biopsies of Patients with Pulmonary Hypertension due to Congenital Heart Disease
  8. Increased Serum Neopterin Concentrations in Patients with Alzheimer’s Disease
  9. Biomarkers of Bone Turnover and Bone Mineral Density in Hyperprolactinemic Amenorrheic Women
  10. Age Relationships and Sex Differences in Serum Levels of Pregnenolone and 17-Hydroxypregnenolone in Normal Subjects
  11. A Study of Hypermagnesaemia in a Hospital Population
  12. Multiple Regression Analysis of Interference Effects from a Hemoglobin-Based Oxygen Carrier Solution
  13. Serum Ionized Magnesium: Comparison of Results Obtained with Three Ion-Selective Analyzers
  14. Automated Prozone Effect Detection in Ferritin Homogeneous Immunoassays Using Neural Network Classifiers
  15. Recent Activities of EC4 in the Harmonization of Clinical Chemistry in the European Union
  16. Preventing Coronary Artery Disease. Cardioprotective Therapeutics in Practice. Edited by M. J. Kendall and R. C. Horton
  17. Will Medical Schools Remain what They Are? Medical Education in the Millennium. Edited by Brian Jolly and Lesley Rees
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