Article
Licensed
Unlicensed Requires Authentication

Isoenzmyes of Class I and II Alcohol Dehydrogenase in Chronic Hepatitis

  • and
Published/Copyright: June 1, 2005
Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 37 Issue 2

Abstract

Using class-specific fluorogenic substrates, the activities of class I and II alcohol dehydrogenase (ADH) isoenzymes were determined in the sera of patients with chronic hepatitis. The activity of the total alcohol dehydrogenase and indicator enzymes of liver damage were also investigated. We found a statistically significant increase of class I alcohol dehydrogenase isoenzymes in the total tested group which included those with the viral hepatitis. The (2-fold) increase in the activity of class I isoenzymes was similar to the increase of aminotransferases. The serum activity of class II isoenzymes was unchanged. Here an increase in total enzyme activity was not statistically significant. Class I isoenzymes and total enzyme activity correlated well with aminotransferases. These results demonstrate that serum activity of class I ADH measured with fluorogenic substrates confirms liver cell damage and may be useful in the diagnosis of chronic hepatitis.

:
Published Online: 2005-06-01
Published in Print: 1999-02-01

Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Evolution or Revolution in Clinical Chemistry
  2. Low Levels of Plasma Proteins: Malnutrition or Inflammation?
  3. Laboratory Medicine: The Need for a Broader View. The “Multiple Bundle” Model of Clinical Laboratory Function
  4. Activated Protein C (APC)-Resistance: Automated Detection of the Point Mutation at Position 1691 in the Factor V Gene
  5. A Rapid and Sensitive Automated Light Scattering Immunoassay for Serum C-Reactive Protein and the Definition of a Reference Range in Healthy Blood Donors
  6. Photodynamic Effects In Vitro in Fresh GynecologicTumors Analyzed with a Bioluminescence Method
  7. An ELISA for the H-Subunit of Human Ferritin which Employs a Combination of Rabbit Poly- and Mice Monoclonal Antibodies and an Enzyme Labeled Anti-Mouse-IgG
  8. The Use of Free Cortisol Index for Laboratory Assessment of Pituitary-Adrenal Function
  9. Allele-Specific Amplification for the Diagnosis of Autosomal Recessive Spinal Muscular Atrophy
  10. Diagnostic Value of Biochemical Markers of Bone Turnover and Postmenopausal Osteoporosis
  11. Isoenzmyes of Class I and II Alcohol Dehydrogenase in Chronic Hepatitis
  12. Screening School Children for Albuminuria, Proteinuria and Occult Blood with Dipsticks
  13. Evaluation of the First Automated Thyroglobulin Assay
  14. Selective Imidazoline Receptor Agonists and Lipid Metabolism
  15. Judgement on Analytical Quality Requirements from Published Clinical Vignette Studies Is Flawed
  16. The Meaning of Good Laboratory Practice (GLP) for the Medical Laboratory
  17. Improved Procedure of Measuring on Radiometer 500 and 600 Series Bloodgas Analysers
  18. Scientific Papers and Presentations by Martha Davis
  19. New Myocardial Marker Proteins in Acute Myocardial Infarction. Quantitative Aspects by J. A. Kragten
  20. Normalwerte by Michael Jakob
  21. Meetings
https://doi.org/10.1515/CCLM.1999.026

Articles in the same Issue

  1. Evolution or Revolution in Clinical Chemistry
  2. Low Levels of Plasma Proteins: Malnutrition or Inflammation?
  3. Laboratory Medicine: The Need for a Broader View. The “Multiple Bundle” Model of Clinical Laboratory Function
  4. Activated Protein C (APC)-Resistance: Automated Detection of the Point Mutation at Position 1691 in the Factor V Gene
  5. A Rapid and Sensitive Automated Light Scattering Immunoassay for Serum C-Reactive Protein and the Definition of a Reference Range in Healthy Blood Donors
  6. Photodynamic Effects In Vitro in Fresh GynecologicTumors Analyzed with a Bioluminescence Method
  7. An ELISA for the H-Subunit of Human Ferritin which Employs a Combination of Rabbit Poly- and Mice Monoclonal Antibodies and an Enzyme Labeled Anti-Mouse-IgG
  8. The Use of Free Cortisol Index for Laboratory Assessment of Pituitary-Adrenal Function
  9. Allele-Specific Amplification for the Diagnosis of Autosomal Recessive Spinal Muscular Atrophy
  10. Diagnostic Value of Biochemical Markers of Bone Turnover and Postmenopausal Osteoporosis
  11. Isoenzmyes of Class I and II Alcohol Dehydrogenase in Chronic Hepatitis
  12. Screening School Children for Albuminuria, Proteinuria and Occult Blood with Dipsticks
  13. Evaluation of the First Automated Thyroglobulin Assay
  14. Selective Imidazoline Receptor Agonists and Lipid Metabolism
  15. Judgement on Analytical Quality Requirements from Published Clinical Vignette Studies Is Flawed
  16. The Meaning of Good Laboratory Practice (GLP) for the Medical Laboratory
  17. Improved Procedure of Measuring on Radiometer 500 and 600 Series Bloodgas Analysers
  18. Scientific Papers and Presentations by Martha Davis
  19. New Myocardial Marker Proteins in Acute Myocardial Infarction. Quantitative Aspects by J. A. Kragten
  20. Normalwerte by Michael Jakob
  21. Meetings
Downloaded on 12.4.2026 from https://www.degruyterbrill.com/document/doi/10.1515/CCLM.1999.026/html
Scroll to top button