A Rapid and Sensitive Automated Light Scattering Immunoassay for Serum C-Reactive Protein and the Definition of a Reference Range in Healthy Blood Donors
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Christopher P. Price
Abstract
The increasing interest in the measurement of serum C-reactive protein in relation to the risk stratification of patients with chest pain has demonstrated the need for more sensitive routine methods of measurement, and an accurate definition of the reference range. We report the determination of a reference range in serum samples from 491 blood donors using a particle enhanced turbidimetric immunoassay that has been modified to offer better imprecision within the reference range. The median values were found to be 2.40 and 2.20 mg/l for males and females, respectively, with 95th percentile range of 1.20–5.20 and 0.40–5.40 mg/l respectively.
Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Evolution or Revolution in Clinical Chemistry
- Low Levels of Plasma Proteins: Malnutrition or Inflammation?
- Laboratory Medicine: The Need for a Broader View. The “Multiple Bundle” Model of Clinical Laboratory Function
- Activated Protein C (APC)-Resistance: Automated Detection of the Point Mutation at Position 1691 in the Factor V Gene
- A Rapid and Sensitive Automated Light Scattering Immunoassay for Serum C-Reactive Protein and the Definition of a Reference Range in Healthy Blood Donors
- Photodynamic Effects In Vitro in Fresh GynecologicTumors Analyzed with a Bioluminescence Method
- An ELISA for the H-Subunit of Human Ferritin which Employs a Combination of Rabbit Poly- and Mice Monoclonal Antibodies and an Enzyme Labeled Anti-Mouse-IgG
- The Use of Free Cortisol Index for Laboratory Assessment of Pituitary-Adrenal Function
- Allele-Specific Amplification for the Diagnosis of Autosomal Recessive Spinal Muscular Atrophy
- Diagnostic Value of Biochemical Markers of Bone Turnover and Postmenopausal Osteoporosis
- Isoenzmyes of Class I and II Alcohol Dehydrogenase in Chronic Hepatitis
- Screening School Children for Albuminuria, Proteinuria and Occult Blood with Dipsticks
- Evaluation of the First Automated Thyroglobulin Assay
- Selective Imidazoline Receptor Agonists and Lipid Metabolism
- Judgement on Analytical Quality Requirements from Published Clinical Vignette Studies Is Flawed
- The Meaning of Good Laboratory Practice (GLP) for the Medical Laboratory
- Improved Procedure of Measuring on Radiometer 500 and 600 Series Bloodgas Analysers
- Scientific Papers and Presentations by Martha Davis
- New Myocardial Marker Proteins in Acute Myocardial Infarction. Quantitative Aspects by J. A. Kragten
- Normalwerte by Michael Jakob
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