Progress in Immunoassay Technology
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Christopher P. Price
Abstract
Immunoassay is now the most widely used analytical technique in laboratory medicine embracing a vast repertoire of analytes and delivered through an increasingly diverse range of devices. This explosion of analytical techniques is complemented by an increasing knowledge base on the antigen antibody reaction that is being used to explore new and improved methodologies.
Our knowledge of the molecular chemistry of the antigen antibody reaction coupled with the molecular biology of immunoglobulin expression has led to the development of antibody and antibody-like molecules with enhanced specificity, and reaction kinetics. These developments include novel fusion proteins, antibody mimics and antibodies that recognise antigen antibody complexes.
The advances in the chemistry of the analytical systems are matched by the design of delivery vehicles: on the one hand the automated analyser that facilitates the analysis of large numbers of samples and on the other, the encapsulated, miniaturised device that enables an immunoassay to be performed at the point of care.
Walter de Gruyter GmbH & Co. KG
Artikel in diesem Heft
- New Trends in Immunoassay Methodology
- Progress in Immunoassay Technology
- Standardization of Steroid Immunoassays – In Theory an Easy Task
- Thermodynamic Parameters in Immunoassay
- Engineering of an Anti-Steroid Antibody: Amino Acid Substitutions Change Antibody Fine Specificity from Cortisol Estradiol
- Antigenic Definition of Cardiac Troponin I
- Peptide Models of Immunological Recognition: Paratope Dissection by Multiple Peptide Synthesis
- Remodeling of Glycoprotein and Carbohydrate Antigens
- Strongly Enhanced Serum Levels of Vascular Endothelial Growth Factor (VEGF) after Poly-trauma and Burn
- Rapid Electrophoretic Separation of Pre-ß-Migrating High Density Lipoproteins Using Automated PhastSystem(tm): Application to Analysis of Lecitihin: Cholesterol Acyltransferase-Deficient Plasma
- Decrease in High Density Lipoprotein Cholesterol (HDL-C) Levels Following Gemfibrozil Therapy
- Reference Intervals for Serum Cystatin C and Serum Creatinine in Adults
- Concepts for a Model of Good Medical Laboratory Services
- Diagnostic Kits Derived from Standard Method "DGKC 94" as a Potential Tool for Improvement of Analytical Standardization and Clinical Utility of Alkaline Phosphatase
- Antioxidant Interferences in Superoxide Dismutase Activity Methods Using Superoxide Radical as Substrate
- Cytokines and Soluble Adhesion Molecules in Laboratory Diagnostics. Report from a Meeting Held at the German Cancer Research Center in Heidelberg on 25 November 1997
- IFCC-WorldLabNews
Artikel in diesem Heft
- New Trends in Immunoassay Methodology
- Progress in Immunoassay Technology
- Standardization of Steroid Immunoassays – In Theory an Easy Task
- Thermodynamic Parameters in Immunoassay
- Engineering of an Anti-Steroid Antibody: Amino Acid Substitutions Change Antibody Fine Specificity from Cortisol Estradiol
- Antigenic Definition of Cardiac Troponin I
- Peptide Models of Immunological Recognition: Paratope Dissection by Multiple Peptide Synthesis
- Remodeling of Glycoprotein and Carbohydrate Antigens
- Strongly Enhanced Serum Levels of Vascular Endothelial Growth Factor (VEGF) after Poly-trauma and Burn
- Rapid Electrophoretic Separation of Pre-ß-Migrating High Density Lipoproteins Using Automated PhastSystem(tm): Application to Analysis of Lecitihin: Cholesterol Acyltransferase-Deficient Plasma
- Decrease in High Density Lipoprotein Cholesterol (HDL-C) Levels Following Gemfibrozil Therapy
- Reference Intervals for Serum Cystatin C and Serum Creatinine in Adults
- Concepts for a Model of Good Medical Laboratory Services
- Diagnostic Kits Derived from Standard Method "DGKC 94" as a Potential Tool for Improvement of Analytical Standardization and Clinical Utility of Alkaline Phosphatase
- Antioxidant Interferences in Superoxide Dismutase Activity Methods Using Superoxide Radical as Substrate
- Cytokines and Soluble Adhesion Molecules in Laboratory Diagnostics. Report from a Meeting Held at the German Cancer Research Center in Heidelberg on 25 November 1997
- IFCC-WorldLabNews
