The Predictive Value of Several Markers in the Progression to Acquired Immunodeficiency Syndrome
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Teresa Planella
Abstract
Serum β2-microglobulin, neopterin, immunoglobulins A, G and M, adenosine deaminase and CD4+ lymphocyte count were evaluated as predictors of progression of HIV-1 infection to AIDS. A population of HIV-1 seropositive, initially asymptomatic men (n=213) and women (n=101) was followed up quarterly.
We estimated the AIDS-free time using the actuarial method (median survival time 47.2 months). Cox proportional hazard analysis revealed that all markers studied were significant (p<0.05) in relation to progression to AIDS. The best markers for predicting progression to AIDS were, in descending order, CD4+ lymphocyte count, β2-microglobulin, IgA, neopterin, IgG, IgM and adenosine deaminase. On stratifying population into four groups (devided at percentiles 25, 50 and 75—from group 1, with values nearest to reference ranges, to group 4, with most abnormal values) we observed statistically significant differences (p<0.05) for all markers except for adenosine deaminase. The relative risk from the Cox proportional hazards model were used to quantify the effects of the best markers and compared to the risk obtained in group 1.
CD4+ lymphocyte count was the best predictor of progression to AIDS. When considering β2-microglobulin and CD4+ together, the relative risk in the group with lowest CD4+ cell count (group 4) ranged from 25.6% (with lower β2-microglobulin values) to 41.1% (with higher β2-microglobulin values). Similar results were obtained when considering neopterin and CD4+ together. The addition of β2-microglobulin or neopterin values to CD4+ lymphocyte count improved the predictive value of CD4+ lymphocyte count.
Copyright © 1998 by Walter de Gruyter GmbH & Co. KG
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Artikel in diesem Heft
- Teaching and Training Laboratory Professionals for the 21st Century
- Comparison of Two Reverse Transcription-Polymerase Chain Reaction Methods for Detection of AML1/ETO Rearrangement in the M2 Subtype of Acute Myeloid Leukaemia
- The Effect of Ascorbic Acid Ingestion on the Biochemical and Physicochemical Risk Factors Associated with Calcium Oxalate Kidney Stone Formation
- Oxidative Stress and Antioxidant Defenses in Renal Patients Receiving Regular Haemodialysis
- Development of an HPLC Assay to Study the Effect of Endogenous and Exogenous Substances on Heat-Induced Aggregation of Human Serum Albumin
- Assessment of Serum Total and Bone Alkaline Phosphatase Measurement in Clinical Practice
- The Predictive Value of Several Markers in the Progression to Acquired Immunodeficiency Syndrome
- The Increase of Plasma Homocysteine Concentrations with Age Is Partly due to the Deterioration of Renal Function as Determined by Plasma Cystatin C
- Serum CA 242: The Search for a Valid Marker of Pancreatic Cancer
- Approved Recommendation on IFCC Methods for the Measurement of Catalytic Concentration of Enzymes Part 9. IFCC Method for α-Amylase (1,4-α-D-Glucan 4-Glucanohydrolase, EC 3.2.1.1)
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