The Increase of Plasma Homocysteine Concentrations with Age Is Partly due to the Deterioration of Renal Function as Determined by Plasma Cystatin C
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Lena Norlund
Abstract
One of the main determinants of plasma homocysteine in healthy subjects is serum creatinine. In the present study, we therefore investigated the relation between plasma homocysteine concentration, serum creatinine and a new marker for glomerular filtration rate, plasma cystatin C concentration. Cystatin C reflects the glomerular filtration better than serum creatinine and is not related to the muscle mass and formation of creatinine. The study group consisted of 255 healthy subjects from a well-defined area in the southern part of Sweden.
The concentration of plasma homocysteine was increased in men compared to women. This difference disappeared when men and women were stratified by serum creatinine values. Statistically significant correlations were noted between plasma homocysteine and age, plasma cystatin C and serum creatinine. It is shown that plasma homocysteine is not only correlated to serum creatinine as a result of renal function but also as a result of the relationship between homocysteine production and creatine-creatinine synthesis. Using linear regression we were able to show that plasma cystatin C had a higher explanatory value than age. Serum creatinine showed a lower explanatory power than age. The findings in the present study might suggest that the increase of plasma homocysteine concentration with age could be partly due to the deterioration of renal function. Study
Copyright © 1998 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Teaching and Training Laboratory Professionals for the 21st Century
- Comparison of Two Reverse Transcription-Polymerase Chain Reaction Methods for Detection of AML1/ETO Rearrangement in the M2 Subtype of Acute Myeloid Leukaemia
- The Effect of Ascorbic Acid Ingestion on the Biochemical and Physicochemical Risk Factors Associated with Calcium Oxalate Kidney Stone Formation
- Oxidative Stress and Antioxidant Defenses in Renal Patients Receiving Regular Haemodialysis
- Development of an HPLC Assay to Study the Effect of Endogenous and Exogenous Substances on Heat-Induced Aggregation of Human Serum Albumin
- Assessment of Serum Total and Bone Alkaline Phosphatase Measurement in Clinical Practice
- The Predictive Value of Several Markers in the Progression to Acquired Immunodeficiency Syndrome
- The Increase of Plasma Homocysteine Concentrations with Age Is Partly due to the Deterioration of Renal Function as Determined by Plasma Cystatin C
- Serum CA 242: The Search for a Valid Marker of Pancreatic Cancer
- Approved Recommendation on IFCC Methods for the Measurement of Catalytic Concentration of Enzymes Part 9. IFCC Method for α-Amylase (1,4-α-D-Glucan 4-Glucanohydrolase, EC 3.2.1.1)
- Erratum
