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Tracer kinetic analysis of signal time series from dynamic contrast-enhanced MR imaging

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Published/Copyright: December 7, 2006
Biomedical Engineering / Biomedizinische Technik
From the journal Volume 51 Issue 5_6

Abstract

Rapid magnetic resonance imaging (MRI) makes it possible to detect the fast kinetics of tissue response after intravenous administration of a paramagnetic contrast medium (CM), reflecting the status of tissue microcirculation. In this paper, the basic physical and tracer kinetic principles of dynamic relaxivity and susceptibility contrast-enhanced MRI are reviewed. Quantitative analysis of data acquired is broken up into an MR-specific part, in which the signal variation observed is related to the CM concentration in the tissue, and an MR-independent part, in which the computed concentration time series are analyzed by tracer kinetic modeling to estimate well-defined physiological tissue parameters. The clinical application of dynamic MRI techniques is demonstrated by two representative studies.

Keywords: dynamic contrast-enhanced MRI; MR signal model; tracer kinetic modeling
Corresponding author: Prof. Dr. Gunnar Brix, Bundesamt für Strahlenschutz (BfS), Abteilung für medizinische Strahlenhygiene und Dosimetrie, Ingolstädter Landstraße 1, 85764 Oberschleissheim, Germany Phone: + 49-1888-333-2300 Fax: + 49-1888-333-2305

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Published Online: 2006-12-07
Published in Print: 2006-12-01

©2006 by Walter de Gruyter Berlin New York

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https://doi.org/10.1515/BMT.2006.065
Keywords for this article
dynamic contrast-enhanced MRI; MR signal model; tracer kinetic modeling

Articles in the same Issue

  1. Biosignal Processing: various concepts, various applications – but a common drive
  2. Detection of directed information flow in biosignals
  3. Data mining in medical time series
  4. State-space analysis of joint angle kinematics in normal treadmill walking
  5. From diagnostics to therapy – conceptual basis for real-time movement feedback in rehabilitation medicine
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  8. Processing of physiological signals in automotive research
  9. Tracer kinetic analysis of signal time series from dynamic contrast-enhanced MR imaging
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