Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren
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Christoph Welp
Abstract
Radiofrequency (RF) ablation using high-frequency current has become an important treatment method for patients with non-resectable liver tumors. Tumor recurrence is associated with tissue cooling in the proximity of large blood vessels. This study investigated the influence of blood flow rate on tissue temperature and lesion size during monopolar RF ablation at a distance of 10 mm from single 4- and 6-mm vessels using two different approaches: 1) an ex vivo blood perfusion circuit including an artificial vessel inserted into porcine liver tissue was developed; and 2) a finite element method (FEM) model was created using a novel simplified modeling technique for large blood vessels. Blood temperatures at the inflow/outflow of the vessel and tissue temperatures at 10 and 20 mm from the electrode tip were measured in the ex vivo set-up. Tissue temperature, blood temperature and lesion size were analyzed under physiological, increased and reduced blood-flow conditions. The results show that changes in blood flow rate in large vessels do not significantly affect tissue temperature and lesion size far away from the vessel. Monopolar ablation could not produce lesions surrounding the vessel due to the strong heat-sink effect. Simulated tissue temperatures correlated well with ex vivo measurements, supporting the FEM model.
Zusammenfassung
Die Radiofrequenzablation mittels hochfrequenten Wechselstroms ist ein Behandlungsverfahren für Patienten mit nicht resezierbaren Lebertumoren. Vereinzelt treten nach der Behandlung erneut Rezidive auf, deren Entstehung auf eine lokale Gewebekühlung durch große Blutgefäße in unmittelbarer Tumornähe zurückgeführt wird. Zur Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gewebetemperaturverteilung und die Läsionsgröße wurden zwei Ansätze gewählt: 1) Ein Perfusionskreislauf mit einem in Schweinelebergewebe (ex vivo) integrierten artifiziellen Blutgefäß wurde entwickelt. 2) Ein Finite-Elemente-Modell der Radiofrequenzablation mit neuem Modellierungsansatz für große Blutgefäße wurde erstellt. Die Bluttemperaturen am Gefäßeintritt und -austritt, die Gewebetemperaturen in einem Abstand von 10 mm und 20 mm zur Applikatorspitze und die Läsionsgröße wurden gemessen (ex vivo Setup) und berechnet (FEM). Dabei wurden drei verschiedene Blutflüsse im Gefäß analysiert: physiologisch, stark erhöht und stark reduziert. Die Ergebnisse zeigen, dass eine Veränderung der Blutflussgeschwindigkeit keinen signifikanten Einfluss auf die Gewebetemperatur in großem Abstand zum Gefäß und auf die Läsionsgröße hat. Mit Hilfe der monopolaren Radiofrequenzablation kann aufgrund der starken Gefäßkühlung (heat sink effect) keine geschlossene Läsionszone um das Gefäß erzielt werden. Die berechneten Gewebetemperaturverteilungen zeigen eine sehr gute Korrelation mit den ex vivo Messergebnissen und stützen damit die Modellierungsmethodik des Finite-Elemente-Modells.
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©2006 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Biosignal Processing: various concepts, various applications – but a common drive
- Detection of directed information flow in biosignals
- Data mining in medical time series
- State-space analysis of joint angle kinematics in normal treadmill walking
- From diagnostics to therapy – conceptual basis for real-time movement feedback in rehabilitation medicine
- Investigations of back muscle fatigue by simultaneous 31P MRS and surface EMG measurements
- Application of EMG signals for controlling exoskeleton robots
- Processing of physiological signals in automotive research
- Tracer kinetic analysis of signal time series from dynamic contrast-enhanced MR imaging
- A fiber optic sensor system for control of rate-adaptive cardiac pacemakers and implantable defibrillators / Ein faseroptisches Sensorsystem zur Steuerung von frequenzadaptiven Herzschrittmachern und implantierbaren Defibrillatoren
- Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren
- Determination of oxygen saturation and hematocrit of flowing human blood using two different spectrally resolving sensors / Bestimmung von Sauerstoffsättigung und Hämatokrit an fließendem Blut mit zwei verschiedenen spektralen Sensoren
- Karl Fischer titration and coulometry for measurement of water content in small cartilage specimens / Bestimmung des Wassergehalts in kleinen Knorpelproben durch Karl-Fischer-Titration und Coulometrie
- Synergistic effects of mixed TiAlV and polyethylene wear particles on TNFα response in THP-1 macrophages / Synergistische Effekte gemischter TiAlV- und Polyethylen-Abriebpartikel auf die TNFα-Antwort in THP-1 Makrophagen
- FE-Simulation zur Lokalisierung hoch beanspruchter Bereiche in der Hüftpfanne von Endoprothesen / FE-analysis of surface stresses for the tribological system in total hip prostheses
- Partial hemi-resurfacing of the hip joint – a new approach to treat local osteochondral defects? / Gelenkoberflächen-Teilersatz am Hüftgelenk – ein neuer Ansatz zur Behandlung osteochondraler Defekte?
- Stellungnahme zu „Der Einfluss von Laserlichtbestrahlung niedriger Leistungsdichte auf einen experimentellen Knorpelschaden im Kniegelenk des Kaninchens: eine in vivo-Untersuchung unter Berücksichtigung makroskopischer, histologischer und immunhistochemischer Veränderungen”; Biomed Tech 2006; 51: 131–138
- Contents index volume 51 (2006)
- Author index volume 51 (2006)
Articles in the same Issue
- Biosignal Processing: various concepts, various applications – but a common drive
- Detection of directed information flow in biosignals
- Data mining in medical time series
- State-space analysis of joint angle kinematics in normal treadmill walking
- From diagnostics to therapy – conceptual basis for real-time movement feedback in rehabilitation medicine
- Investigations of back muscle fatigue by simultaneous 31P MRS and surface EMG measurements
- Application of EMG signals for controlling exoskeleton robots
- Processing of physiological signals in automotive research
- Tracer kinetic analysis of signal time series from dynamic contrast-enhanced MR imaging
- A fiber optic sensor system for control of rate-adaptive cardiac pacemakers and implantable defibrillators / Ein faseroptisches Sensorsystem zur Steuerung von frequenzadaptiven Herzschrittmachern und implantierbaren Defibrillatoren
- Investigation of the influence of blood flow rate on large vessel cooling in hepatic radiofrequency ablation / Untersuchung des Einflusses der Blutflussgeschwindigkeit auf die Gefäßkühlung bei der Radiofrequenzablation von Lebertumoren
- Determination of oxygen saturation and hematocrit of flowing human blood using two different spectrally resolving sensors / Bestimmung von Sauerstoffsättigung und Hämatokrit an fließendem Blut mit zwei verschiedenen spektralen Sensoren
- Karl Fischer titration and coulometry for measurement of water content in small cartilage specimens / Bestimmung des Wassergehalts in kleinen Knorpelproben durch Karl-Fischer-Titration und Coulometrie
- Synergistic effects of mixed TiAlV and polyethylene wear particles on TNFα response in THP-1 macrophages / Synergistische Effekte gemischter TiAlV- und Polyethylen-Abriebpartikel auf die TNFα-Antwort in THP-1 Makrophagen
- FE-Simulation zur Lokalisierung hoch beanspruchter Bereiche in der Hüftpfanne von Endoprothesen / FE-analysis of surface stresses for the tribological system in total hip prostheses
- Partial hemi-resurfacing of the hip joint – a new approach to treat local osteochondral defects? / Gelenkoberflächen-Teilersatz am Hüftgelenk – ein neuer Ansatz zur Behandlung osteochondraler Defekte?
- Stellungnahme zu „Der Einfluss von Laserlichtbestrahlung niedriger Leistungsdichte auf einen experimentellen Knorpelschaden im Kniegelenk des Kaninchens: eine in vivo-Untersuchung unter Berücksichtigung makroskopischer, histologischer und immunhistochemischer Veränderungen”; Biomed Tech 2006; 51: 131–138
- Contents index volume 51 (2006)
- Author index volume 51 (2006)
