Startseite The l-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function
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The l-arginine nitric oxide pathway: avenue for a multiple-level approach to assess vascular function

  • Tienush Rassaf , Petra Kleinbongard und Malte Kelm
Veröffentlicht/Copyright: 2. November 2006
Biological Chemistry
Aus der Zeitschrift Band 387 Heft 10_11

Abstract

Endothelial dysfunction is an early stage of atherosclerosis and has been attributed to impaired nitric oxide (NO) bioactivity and enhanced formation of oxygen-derived free radicals. Given that endothelial dysfunction is at least in part reversible, the assessment of altered NO availability is of important diagnostic and prognostic significance. Identification of such alterations may help to target asymptomatic individuals who are at risk for cardiovascular diseases and would likely benefit from preventive measures. Focusing on a single signaling pathway, we present here a multi-level approach for the early diagnosis of cardiovascular diseases by assessing molecular, biochemical, structural, and functional changes in the vascular wall.

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Published Online: 2006-11-02
Published in Print: 2006-10-01

©2006 by Walter de Gruyter Berlin New York

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