Truncated PrPc in mammalian brain: interspecies variation and location in membrane rafts
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Isabelle Laffont-Proust
Abstract
A key molecular event in prion diseases is the conversion of cellular prion protein (PrPc) into an abnormal misfolded conformer (PrPsc). The PrPc N-terminal domain plays a central role in PrPc functions and in prion propagation. Because mammalian PrPc is found as a full-length and N-terminally truncated form, we examined the presence and amount of PrPc C-terminal fragment in the brain of different species. We found important variations between primates and rodents. In addition, our data show that the PrPc fragment is present in detergent-resistant raft domains, a membrane domain of critical importance for PrPc functions and its conversion into PrPsc.
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©2006 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Striated domains: self-organizing ordered assemblies of transmembrane α-helical peptides and lipids in bilayers
- Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitors
- Rec A-independent homologous recombination induced by a putative fold-back tetraplex DNA
- Spontaneous DNA-DNA interaction of homologous duplexes and factors affecting the result of heteroduplex formation
- DNA end-joining driven by microhomologies catalyzed by nuclear extracts
- A role for transmembrane domains V and VI in ligand binding and maturation of the angiotensin II AT1 receptor
- The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB
- Pressure- and temperature-induced unfolding studies: thermodynamics of core hydrophobicity and packing of ribonuclease A
- Truncated PrPc in mammalian brain: interspecies variation and location in membrane rafts
- Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization
- p190-RhoGAP as an integral component of the Tiam1/Rac1-induced downregulation of Rho
- Human plasma adenosine deaminase 2 is secreted by activated monocytes
- Inhibition of mRNA deadenylation and degradation by different types of cell stress
- Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19INK4d
- Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8
