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How do ABC transporters drive transport?

  • Chris Van Der Does and Robert Tampé
Published/Copyright: June 1, 2005
Biological Chemistry
From the journal Volume 385 Issue 10

Abstract

Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins that hydrolyze ATP to drive transport. In the last two decades these proteins have been extensively characterized on a genetic and biochemical level, and in recent years high-resolution crystal structures of several nucleotide-binding domains and full-length transporters have extended our knowledge. Here we discuss the possible mechanisms of transport that have been derived from these crystal structures and the extensive available biochemical data.

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Published Online: 2005-06-01
Published in Print: 2004-10-01

© Walter de Gruyter

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