Article
Licensed
Unlicensed
Requires Authentication
The Tranquilizing Injection of Yersinia Proteins: A Pathogens Strategy to Resist Host Defense
-
M. Aepfelbacher
Published/Copyright:
June 1, 2005
Abstract
Pathogenic bacteria of the genus Yersinia possess a type III secretion apparatus by which they can inject up to six effector proteins into host cells. These so-called effector Yops(Y̱ersinia) o̱uter; p̱roteins) disrupt cellular immune defense functions such as TNF-α release, O2− production or phagocytosis and thereby allow Yersinia to grow extracellularly. Recent findings indicate that the effector Yops are highly active proteins that engage in crucial eukaryotic signaling mechanisms. For instance, the translocated tyrosine phosphatase YopH dephosphorylates the focal adhesion proteins paxillin and p130Cas within target cells. Furthermore, the Yersinia effector YopP is able to induce apoptosis in macrophages presumably by blocking MAP kinase and NF κB mediated signaling events. Here we discuss recent advances concerning the intracellular targets and biochemical signaling mechanisms regulated by the translocated Yersinia effectors.
:
Published Online: 2005-06-01
Published in Print: 1999-07-01
Copyright © 1999 by Walter de Gruyter GmbH & Co. KG
You are currently not able to access this content.
You are currently not able to access this content.
Articles in the same Issue
- Paul Nurse Felix Hoppe-Seyler Lecturer 1999
- Cyclin Dependent Kinases and Regulation of the Fission Yeast Cell Cycle
- Paper of the Year 1998
- Autonomous Regulation in Mammalian Mitochondrial DNA Transcription
- Prospects for the Precise Engineering of Plant Genomes by Homologous Recombination
- The Glycosphingolipidoses from Disease to Basic Principles of Metabolism
- The Dual Role of Lipopolysaccharide as Effector and Target Molecule
- A Unified Mechanism of Enzymatic Synthesis of Two Calcium Messengers: Cyclic ADP-Ribose and NAADP
- The Tranquilizing Injection of Yersinia Proteins: A Pathogens Strategy to Resist Host Defense
- IL-6 Type Cytokine Receptor Complexes: Hexamer, Tetramer or Both?
- Genetically Engineered and Synthetic Allergen Derivatives: Candidates for Vaccination against Type I Allergy
- Molecular Farming of Recombinant Antibodies in Plants
- Chimeric Restriction Enzymes: What Is Next?
- Viroids with Hammerhead Ribozymes: Some Unique Structural and Functional Aspects with Respect to Other Members of the Group
- Mutagenesis via Insertional or Restriction Enzyme-Mediated Integration (REMI) as a Tool to Tag Pathogenicity Related Genes in Plant Pathogenic Fungi
- Role of Mitochondria in Parkinson Disease
- Mitochondria Harbouring Mutant mtDNA a Cuckoo in the Nest?
- Mutant p53: Gain-of-Function Oncoproteins and Wild-Type p53 Inactivators
- The Role of Chemokines in Cutaneous Allergic Inflammation
- Mutations of Calcium Channel beta Subunit Genes in Mice
- Agonist-Stimulated Pathways of Calcium Signaling in Pancreatic Acinar Cells
- Some of the Early Events Underlying Th2. Cell Maturation and Susceptibility to Leishmania major Infection in BALB/c Mice
- Universal and Unique Features of Kinesin Motors: Insights from a Comparison of Fungal and Animal Conventional Kinesins
- Elementary Steps in Protein Folding
- Molecular Reaction Mechanisms of Proteins Monitored by Time-Resolved FTIR-Spectroscopy
- Sugars as Signal Molecules in Plant Seed Development
- Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research?
- A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation
- Processing of Artificial Peptide-DNA-Conjugates by the Mitochondrial Intermediate Peptidase (MIP)
- The Two SH2-Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 Are Coexpressed in Human T Lymphocytes
- Differential Distribution of Four Hyperpolarization-Activated Cation Channels in Mouse Brain
- The Structure of the Nucleotide-Binding Site of Kinesin
- Atomic Resolution Crystal Structure of Hydroxynitrile Lyase from <I>Hevea brasiliensis</I>
- Comparative Modeling of Amoebapores and Granulysin Based on the NK-Lysin Structure Structural and Functional Implications
- A Nonspecific, Single-Stranded Nuclease Activity with Characteristics of a Topoisomerase Found in a Major Grass Pollen Allergen: Possible Biological Significance
- Functional Characterisation of Dictyostelium Myosin II with Conserved Tryptophanyl Residue 501 Mutated to Tyrosine
- Mitochondrial Nitric Oxide Synthase Regulates Mitochondrial Matrix pH
- Directed Evolution of an Esterase from Pseudomonas fluorescens. Random Mutagenesis by Error-Prone PCR or a Mutator Strain and Identification of Mutants Showing Enhanced Enantioselectivity by a Resorufin-Based Fluorescence Assay
Articles in the same Issue
- Paul Nurse Felix Hoppe-Seyler Lecturer 1999
- Cyclin Dependent Kinases and Regulation of the Fission Yeast Cell Cycle
- Paper of the Year 1998
- Autonomous Regulation in Mammalian Mitochondrial DNA Transcription
- Prospects for the Precise Engineering of Plant Genomes by Homologous Recombination
- The Glycosphingolipidoses from Disease to Basic Principles of Metabolism
- The Dual Role of Lipopolysaccharide as Effector and Target Molecule
- A Unified Mechanism of Enzymatic Synthesis of Two Calcium Messengers: Cyclic ADP-Ribose and NAADP
- The Tranquilizing Injection of Yersinia Proteins: A Pathogens Strategy to Resist Host Defense
- IL-6 Type Cytokine Receptor Complexes: Hexamer, Tetramer or Both?
- Genetically Engineered and Synthetic Allergen Derivatives: Candidates for Vaccination against Type I Allergy
- Molecular Farming of Recombinant Antibodies in Plants
- Chimeric Restriction Enzymes: What Is Next?
- Viroids with Hammerhead Ribozymes: Some Unique Structural and Functional Aspects with Respect to Other Members of the Group
- Mutagenesis via Insertional or Restriction Enzyme-Mediated Integration (REMI) as a Tool to Tag Pathogenicity Related Genes in Plant Pathogenic Fungi
- Role of Mitochondria in Parkinson Disease
- Mitochondria Harbouring Mutant mtDNA a Cuckoo in the Nest?
- Mutant p53: Gain-of-Function Oncoproteins and Wild-Type p53 Inactivators
- The Role of Chemokines in Cutaneous Allergic Inflammation
- Mutations of Calcium Channel beta Subunit Genes in Mice
- Agonist-Stimulated Pathways of Calcium Signaling in Pancreatic Acinar Cells
- Some of the Early Events Underlying Th2. Cell Maturation and Susceptibility to Leishmania major Infection in BALB/c Mice
- Universal and Unique Features of Kinesin Motors: Insights from a Comparison of Fungal and Animal Conventional Kinesins
- Elementary Steps in Protein Folding
- Molecular Reaction Mechanisms of Proteins Monitored by Time-Resolved FTIR-Spectroscopy
- Sugars as Signal Molecules in Plant Seed Development
- Diphosphoinositol Polyphosphates: The Final Frontier for Inositide Research?
- A Role of Poly (ADP-Ribose) Polymerase in NF- B Transcriptional Activation
- Processing of Artificial Peptide-DNA-Conjugates by the Mitochondrial Intermediate Peptidase (MIP)
- The Two SH2-Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 Are Coexpressed in Human T Lymphocytes
- Differential Distribution of Four Hyperpolarization-Activated Cation Channels in Mouse Brain
- The Structure of the Nucleotide-Binding Site of Kinesin
- Atomic Resolution Crystal Structure of Hydroxynitrile Lyase from <I>Hevea brasiliensis</I>
- Comparative Modeling of Amoebapores and Granulysin Based on the NK-Lysin Structure Structural and Functional Implications
- A Nonspecific, Single-Stranded Nuclease Activity with Characteristics of a Topoisomerase Found in a Major Grass Pollen Allergen: Possible Biological Significance
- Functional Characterisation of Dictyostelium Myosin II with Conserved Tryptophanyl Residue 501 Mutated to Tyrosine
- Mitochondrial Nitric Oxide Synthase Regulates Mitochondrial Matrix pH
- Directed Evolution of an Esterase from Pseudomonas fluorescens. Random Mutagenesis by Error-Prone PCR or a Mutator Strain and Identification of Mutants Showing Enhanced Enantioselectivity by a Resorufin-Based Fluorescence Assay
