Mathematical modeling of AI application for the diagnosis of blood flow disorders
-
Egor V. Kochetov
Abstract
The mathematical modeling of machine learning application for the diagnosis of blood flow disorders in the vessels of a systemic circulation of human circulation is considered. Based on mathematical modeling of blood flow in the approximation of quasi-one-dimensional hemodynamics, a procedure for forming a virtual database for learning and diagnostics is proposed. Estimates of the accuracy of diagnosis using the proposed tools is obtained for a certain set of circulatory pathologies. It is shown that a number of characteristic blood flow disorders reproduced in computational experiments are determined with satisfactory reliability.
Abstract
The mathematical modeling of machine learning application for the diagnosis of blood flow disorders in the vessels of a systemic circulation of human circulation is considered. Based on mathematical modeling of blood flow in the approximation of quasi-one-dimensional hemodynamics, a procedure for forming a virtual database for learning and diagnostics is proposed. Estimates of the accuracy of diagnosis using the proposed tools is obtained for a certain set of circulatory pathologies. It is shown that a number of characteristic blood flow disorders reproduced in computational experiments are determined with satisfactory reliability.
Kapitel in diesem Buch
- Frontmatter I
- Prologue I VII
- Prologue II XI
- Prologue III XIII
- Preface XVII
- Overview XIX
- Contents XXXIII
-
Part I: Theories
-
Part I-A: Overarching theory
- Introduction 1
- Universal axioms in classical Chinese philosophy 5
- Category theory for structural characterization 15
- Axiomatic bipolar dynamics and their control 45
-
Part I-B: Systems theories
- Introduction 75
- Stochastic formalization of agent-oriented systems 79
- Simplification of high-dimensional multitempo dynamic models 109
- Ideas of symmetry as a biophysical basis of system biomedicine 123
- Disorder of multiscale control 149
-
Part II: Person’s life-sphere
-
Part II-A: Person’s biosphere
- Introduction 185
- Mutations as activators of biological evolutionary processes at population levels 189
- Immunometabolism of T-cells in COVID-19 209
-
Part II-A.2: Body’s vital functions
- Introduction 245
- Structural modeling of vascular networks 249
- Mathematical modeling of AI application for the diagnosis of blood flow disorders 283
- Modeling of glucose and insulin regulation within the framework of a self-consistent model of the cardiovascular system 303
- Hemodynamics in residual myocardial ischemia 319
- The quasi-one-dimensional model of the lymph flow in the human lymphatic system 335
- An integrate-and-fire mechanism for modeling rhythmicity in the neuroendocrine system 365
- Kinetic network modeling of the neuroendocrine hypothalamic-pituitary-adrenal axis dynamics with particular attention on the role of alcohol as a digestif 377
- Inflammation and immune response in atherosclerosis 393
-
Part II-A.3: Body’s motor functions
- Introduction 423
- A magnetic resonance spectroscopy approach to quantitatively measure GABA and phosphorus level changes in the primary motor cortex elicited by transcranial direct current stimulation 427
-
Part II-A.4: Body’s operational functions
- Introduction 441
- The fermionic mind hypothesis–a category-theoretic verification of consciousness 445
- Cross-task cognitive workload measurement based on the sample selection of the EEG data 459
-
Part II-B: Person’s eco-sphere exposures
- Introduction 475
- The spread of SARS-CoV-2 in Russia and the evolution of the properties of the pathogen 479
- Agent-based modeling of epidemic spread via kinetic Monte Carlo method 491
- Control of SARS-nCoV outbreaks in China 2020 513
-
Part II-B.2: Civilization
- Introduction 531
- Pesticide exposure: Toward holistic environmental modeling 535
-
Part II-C: Person’s sociosphere exposures
- Introduction 559
- Evolution of the health system in Shanghai, China, 2016–2020 563
-
Part III: Technologies
- Introduction 577
- Design-process automation using functional process blocks 581
- Slow/fast dynamic models with applications to engineering problems 601
-
Part III-B: Information sciences
- Introduction 613
- Numerical modeling of medical ultrasound using the grid-characteristic method 617
- The direct and the inverse magnetic encephalography problem 635
-
Part III-C: Data-analytic sciences
- Introduction 653
- Assessing the bioequivalence of two different drugs with the same active ingredient 655
- Estimation of adjusted relative risks in log-binomial regression using the Bekhit–Schöpe–Wagenpfeil algorithm 665
-
Part IV: Clinical medicine
- Introduction 679
- Finding optimal two-stage combined treatment protocols for a blood cancer model 681
- Unraveling the mysteries: Mathematical perspectives on traditional Chinese medicine meridians 697
- Epilogue 721
- Index 723
Kapitel in diesem Buch
- Frontmatter I
- Prologue I VII
- Prologue II XI
- Prologue III XIII
- Preface XVII
- Overview XIX
- Contents XXXIII
-
Part I: Theories
-
Part I-A: Overarching theory
- Introduction 1
- Universal axioms in classical Chinese philosophy 5
- Category theory for structural characterization 15
- Axiomatic bipolar dynamics and their control 45
-
Part I-B: Systems theories
- Introduction 75
- Stochastic formalization of agent-oriented systems 79
- Simplification of high-dimensional multitempo dynamic models 109
- Ideas of symmetry as a biophysical basis of system biomedicine 123
- Disorder of multiscale control 149
-
Part II: Person’s life-sphere
-
Part II-A: Person’s biosphere
- Introduction 185
- Mutations as activators of biological evolutionary processes at population levels 189
- Immunometabolism of T-cells in COVID-19 209
-
Part II-A.2: Body’s vital functions
- Introduction 245
- Structural modeling of vascular networks 249
- Mathematical modeling of AI application for the diagnosis of blood flow disorders 283
- Modeling of glucose and insulin regulation within the framework of a self-consistent model of the cardiovascular system 303
- Hemodynamics in residual myocardial ischemia 319
- The quasi-one-dimensional model of the lymph flow in the human lymphatic system 335
- An integrate-and-fire mechanism for modeling rhythmicity in the neuroendocrine system 365
- Kinetic network modeling of the neuroendocrine hypothalamic-pituitary-adrenal axis dynamics with particular attention on the role of alcohol as a digestif 377
- Inflammation and immune response in atherosclerosis 393
-
Part II-A.3: Body’s motor functions
- Introduction 423
- A magnetic resonance spectroscopy approach to quantitatively measure GABA and phosphorus level changes in the primary motor cortex elicited by transcranial direct current stimulation 427
-
Part II-A.4: Body’s operational functions
- Introduction 441
- The fermionic mind hypothesis–a category-theoretic verification of consciousness 445
- Cross-task cognitive workload measurement based on the sample selection of the EEG data 459
-
Part II-B: Person’s eco-sphere exposures
- Introduction 475
- The spread of SARS-CoV-2 in Russia and the evolution of the properties of the pathogen 479
- Agent-based modeling of epidemic spread via kinetic Monte Carlo method 491
- Control of SARS-nCoV outbreaks in China 2020 513
-
Part II-B.2: Civilization
- Introduction 531
- Pesticide exposure: Toward holistic environmental modeling 535
-
Part II-C: Person’s sociosphere exposures
- Introduction 559
- Evolution of the health system in Shanghai, China, 2016–2020 563
-
Part III: Technologies
- Introduction 577
- Design-process automation using functional process blocks 581
- Slow/fast dynamic models with applications to engineering problems 601
-
Part III-B: Information sciences
- Introduction 613
- Numerical modeling of medical ultrasound using the grid-characteristic method 617
- The direct and the inverse magnetic encephalography problem 635
-
Part III-C: Data-analytic sciences
- Introduction 653
- Assessing the bioequivalence of two different drugs with the same active ingredient 655
- Estimation of adjusted relative risks in log-binomial regression using the Bekhit–Schöpe–Wagenpfeil algorithm 665
-
Part IV: Clinical medicine
- Introduction 679
- Finding optimal two-stage combined treatment protocols for a blood cancer model 681
- Unraveling the mysteries: Mathematical perspectives on traditional Chinese medicine meridians 697
- Epilogue 721
- Index 723