10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development
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Rajiv Karmakar
Abstract
Benzothiazole scaffolds exhibit exciting medicinal properties including anticancer. In recent timemost complicated job for every researcher is to discover a novel drug that can treat cancer with minimal side effects. Some heterocyclic anticancer drugs including daunorubicin, 5-flourouracil, doxorubicin, methotrexate, etc. are markedly available. In addition, few natural products such as vincristine alongwith vinblastine are used as anticancer drugs. More than 90% of the novel drugs bearing heterocyclic moieties have always been main portions in the development of anticancer drugs. Heterocyclic compounds containing benzothiazole moiety show a superior pharmaceutical effect than non-nitrogen compounds. These N-/S-containing benzothiazole compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in our living cells. This chapter recites the weightage of benzothiazole nuclei in the progress of anticancer drugs.
Abstract
Benzothiazole scaffolds exhibit exciting medicinal properties including anticancer. In recent timemost complicated job for every researcher is to discover a novel drug that can treat cancer with minimal side effects. Some heterocyclic anticancer drugs including daunorubicin, 5-flourouracil, doxorubicin, methotrexate, etc. are markedly available. In addition, few natural products such as vincristine alongwith vinblastine are used as anticancer drugs. More than 90% of the novel drugs bearing heterocyclic moieties have always been main portions in the development of anticancer drugs. Heterocyclic compounds containing benzothiazole moiety show a superior pharmaceutical effect than non-nitrogen compounds. These N-/S-containing benzothiazole compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in our living cells. This chapter recites the weightage of benzothiazole nuclei in the progress of anticancer drugs.
Chapters in this book
- Frontmatter I
- Preface VII
- Contents IX
- List of contributing authors XVII
- 1 Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs 1
- 2 Naturally occurring heterocyclic anticancer compounds 55
- 3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents 83
- 4 Advances in heterocycles as DNA intercalating cancer drugs 111
- 5 Recent advances of heterocycle based anticancer hybrids 161
- 6 Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline as anticancer agents 185
- 7 Updates on the versatile quinoline heterocycles as anticancer agents 249
- 8 Recent development of imidazole derivatives as potential anticancer agents 267
- 9 Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules 307
- 10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development 343
- 11 Triazine based chemical entities for anticancer activity 387
- 12 Anticancer properties of arylchromenes and arylchromans: an overview 419
- 13 Anticancer potential of indole derivatives: an update 453
- 14 Indole based prostate cancer agents 479
- Index 503
Chapters in this book
- Frontmatter I
- Preface VII
- Contents IX
- List of contributing authors XVII
- 1 Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs 1
- 2 Naturally occurring heterocyclic anticancer compounds 55
- 3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents 83
- 4 Advances in heterocycles as DNA intercalating cancer drugs 111
- 5 Recent advances of heterocycle based anticancer hybrids 161
- 6 Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline as anticancer agents 185
- 7 Updates on the versatile quinoline heterocycles as anticancer agents 249
- 8 Recent development of imidazole derivatives as potential anticancer agents 267
- 9 Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules 307
- 10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development 343
- 11 Triazine based chemical entities for anticancer activity 387
- 12 Anticancer properties of arylchromenes and arylchromans: an overview 419
- 13 Anticancer potential of indole derivatives: an update 453
- 14 Indole based prostate cancer agents 479
- Index 503
