3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents
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Arvind Singh
Abstract
2-Hydroxy-1,4-naphthaquinone, commonly known as lawsone, represents an extremely important biologically active naturally occurring compound. It can easily be isolated from Lawsonia inermis (henna) tree leaf extract. Last decade has seen tremendous applications of lawsone as a starting component for the preparation of various organic scaffolds. Many of these synthesized scaffolds showed a wide range of biological activities including potential activities towards several cancer cell lines. This review deals with diverse synthetic methods of lawsone derived scaffolds and their screening against different anti-cancer cell lines along with promising results.
Abstract
2-Hydroxy-1,4-naphthaquinone, commonly known as lawsone, represents an extremely important biologically active naturally occurring compound. It can easily be isolated from Lawsonia inermis (henna) tree leaf extract. Last decade has seen tremendous applications of lawsone as a starting component for the preparation of various organic scaffolds. Many of these synthesized scaffolds showed a wide range of biological activities including potential activities towards several cancer cell lines. This review deals with diverse synthetic methods of lawsone derived scaffolds and their screening against different anti-cancer cell lines along with promising results.
Chapters in this book
- Frontmatter I
- Preface VII
- Contents IX
- List of contributing authors XVII
- 1 Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs 1
- 2 Naturally occurring heterocyclic anticancer compounds 55
- 3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents 83
- 4 Advances in heterocycles as DNA intercalating cancer drugs 111
- 5 Recent advances of heterocycle based anticancer hybrids 161
- 6 Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline as anticancer agents 185
- 7 Updates on the versatile quinoline heterocycles as anticancer agents 249
- 8 Recent development of imidazole derivatives as potential anticancer agents 267
- 9 Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules 307
- 10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development 343
- 11 Triazine based chemical entities for anticancer activity 387
- 12 Anticancer properties of arylchromenes and arylchromans: an overview 419
- 13 Anticancer potential of indole derivatives: an update 453
- 14 Indole based prostate cancer agents 479
- Index 503
Chapters in this book
- Frontmatter I
- Preface VII
- Contents IX
- List of contributing authors XVII
- 1 Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs 1
- 2 Naturally occurring heterocyclic anticancer compounds 55
- 3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents 83
- 4 Advances in heterocycles as DNA intercalating cancer drugs 111
- 5 Recent advances of heterocycle based anticancer hybrids 161
- 6 Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline as anticancer agents 185
- 7 Updates on the versatile quinoline heterocycles as anticancer agents 249
- 8 Recent development of imidazole derivatives as potential anticancer agents 267
- 9 Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules 307
- 10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development 343
- 11 Triazine based chemical entities for anticancer activity 387
- 12 Anticancer properties of arylchromenes and arylchromans: an overview 419
- 13 Anticancer potential of indole derivatives: an update 453
- 14 Indole based prostate cancer agents 479
- Index 503
