4 Advances in heterocycles as DNA intercalating cancer drugs
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Aparna Das
Abstract
The insertion of a molecule between the bases of DNA is known as intercalation. A molecule is able to interact with DNA in different ways. DNA intercalators are generally aromatic, planar, and polycyclic. In chemotherapeutic treatment, to suppress DNA replication in cancer cells, intercalators are used. In this article, we discuss the anticancer activity of 10 intensively studied DNA intercalators as drugs. The list includes proflavine, ethidium bromide, doxorubicin, dactinomycin, bleomycin, epirubicin, mitoxantrone, ellipticine, elinafide, and echinomycin. Considerable structural diversities are seen in these molecules. Besides, some examples of the metallo-intercalators are presented at the end of the chapter. These molecules have other crucial properties that are also useful in the treatment of cancers. The successes and limitations of these molecules are also presented.
Abstract
The insertion of a molecule between the bases of DNA is known as intercalation. A molecule is able to interact with DNA in different ways. DNA intercalators are generally aromatic, planar, and polycyclic. In chemotherapeutic treatment, to suppress DNA replication in cancer cells, intercalators are used. In this article, we discuss the anticancer activity of 10 intensively studied DNA intercalators as drugs. The list includes proflavine, ethidium bromide, doxorubicin, dactinomycin, bleomycin, epirubicin, mitoxantrone, ellipticine, elinafide, and echinomycin. Considerable structural diversities are seen in these molecules. Besides, some examples of the metallo-intercalators are presented at the end of the chapter. These molecules have other crucial properties that are also useful in the treatment of cancers. The successes and limitations of these molecules are also presented.
Chapters in this book
- Frontmatter I
- Preface VII
- Contents IX
- List of contributing authors XVII
- 1 Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs 1
- 2 Naturally occurring heterocyclic anticancer compounds 55
- 3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents 83
- 4 Advances in heterocycles as DNA intercalating cancer drugs 111
- 5 Recent advances of heterocycle based anticancer hybrids 161
- 6 Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline as anticancer agents 185
- 7 Updates on the versatile quinoline heterocycles as anticancer agents 249
- 8 Recent development of imidazole derivatives as potential anticancer agents 267
- 9 Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules 307
- 10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development 343
- 11 Triazine based chemical entities for anticancer activity 387
- 12 Anticancer properties of arylchromenes and arylchromans: an overview 419
- 13 Anticancer potential of indole derivatives: an update 453
- 14 Indole based prostate cancer agents 479
- Index 503
Chapters in this book
- Frontmatter I
- Preface VII
- Contents IX
- List of contributing authors XVII
- 1 Naturally occurring, natural product inspired and synthetic heterocyclic anti-cancer drugs 1
- 2 Naturally occurring heterocyclic anticancer compounds 55
- 3 Lawsone (2-hydroxy-1,4-naphthaquinone) derived anticancer agents 83
- 4 Advances in heterocycles as DNA intercalating cancer drugs 111
- 5 Recent advances of heterocycle based anticancer hybrids 161
- 6 Fused pyrrolo-pyridines and pyrrolo-(iso) quinoline as anticancer agents 185
- 7 Updates on the versatile quinoline heterocycles as anticancer agents 249
- 8 Recent development of imidazole derivatives as potential anticancer agents 267
- 9 Recent developments in the synthesis and anti-cancer activity of acridine and xanthine-based molecules 307
- 10 Synthesis of new horizons in benzothiazole scaffold and used in anticancer drug development 343
- 11 Triazine based chemical entities for anticancer activity 387
- 12 Anticancer properties of arylchromenes and arylchromans: an overview 419
- 13 Anticancer potential of indole derivatives: an update 453
- 14 Indole based prostate cancer agents 479
- Index 503
