Skip to main content
Chapter
Licensed
Unlicensed Requires Authentication

9 Iron Oxide Nanoparticles for Bio-Imaging

  • and
Become an author with De Gruyter Brill
Explore this Subject How to publish with us
Metal Ions in Bio-Imaging Techniques
This chapter is in the book Metal Ions in Bio-Imaging Techniques

Abstract

Iron oxide nanoparticles (IONPs) have been studied extensively and used as platforms for bio-imaging applications. This is the result of their strong Magnetic Resonance Imaging (MRI) contrast enhancement effects which brought them to clinical use, their recent development as Magnetic Particle Imaging (MPI) probes and their versatility for multimodality imaging applications. In this chapter we first describe their main synthetic methodologies, their characterization techniques and the physico-chemical properties, in vivo biodistribution, excretion, toxicity and degradation processes that are at the basis of their imaging applications. The contrast mechanisms used by IONPs in MRI and MPI are described, and are illustrated by typical examples of their use for in vivo pre-clinical single modality and multimodality molecular imaging applications. Perspectives on their use in theranostic and potential clinical developments are also discussed.

Abstract

Iron oxide nanoparticles (IONPs) have been studied extensively and used as platforms for bio-imaging applications. This is the result of their strong Magnetic Resonance Imaging (MRI) contrast enhancement effects which brought them to clinical use, their recent development as Magnetic Particle Imaging (MPI) probes and their versatility for multimodality imaging applications. In this chapter we first describe their main synthetic methodologies, their characterization techniques and the physico-chemical properties, in vivo biodistribution, excretion, toxicity and degradation processes that are at the basis of their imaging applications. The contrast mechanisms used by IONPs in MRI and MPI are described, and are illustrated by typical examples of their use for in vivo pre-clinical single modality and multimodality molecular imaging applications. Perspectives on their use in theranostic and potential clinical developments are also discussed.

Chapters in this book

  1. Frontmatter i
  2. About the Editors v
  3. Historical Development and Perspectives of the Series Metal Ions in Life Sciences vii
  4. Preface to Volume 22 Metal Ions in Bio-Imaging Techniques ix
  5. Contents xiii
  6. Contributors to Volume 22 xix
  7. Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series xxiii
  8. Contents of Volumes in the Metal Ions in Life Sciences Series xxv
  9. 1 Metal Ions in Bio-Imaging Techniques: A Short Overview 1
  10. 2 Gadolinium(III)-Based Contrast Agents for Magnetic Resonance Imaging. A Re-Appraisal 39
  11. 3 Manganese Complexes as Contrast Agents for Magnetic Resonance Imaging 71
  12. 4 Metal Ion Complexes in Paramagnetic Chemical Exchange Saturation Transfer (ParaCEST) 101
  13. 5 Lanthanide Complexes Used for Optical Imaging 137
  14. 6 Radiometals for Positron Emission Tomography (PET) Imaging 157
  15. 7 99mTechnetium-Based Imaging Agents and Developments in 99Tc Chemistry 195
  16. 8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging 239
  17. 9 Iron Oxide Nanoparticles for Bio-Imaging 271
  18. 10 Magnetic Resonance Contrast Enhancement and Therapeutic Properties of Corrole Nanoparticles 299
  19. 11 Positron Emission Tomography (PET) Driven Theranostics 315
  20. 12 Magnetic Resonance Theranostics: An Overview of Gadolinium(III)-Based Strategies and Magnetic Particle Imaging 347
  21. 13 Luminescence Imaging of Cancer Cells 371
  22. 14 Iridium(III) Complexes in Bio-Imaging Including Mitochondria 403
  23. 15 Imaging Bacteria with Contrast-Enhanced Magnetic Resonance 425
  24. 16 Transition Metals and Imaging Probes in Neurobiology and Neurodegenerative Diseases 437
  25. 17 Heavy Elements for X-Ray Contrast 457
  26. Subject Index 485
https://doi.org/10.1515/9783110685701-015

Chapters in this book

  1. Frontmatter i
  2. About the Editors v
  3. Historical Development and Perspectives of the Series Metal Ions in Life Sciences vii
  4. Preface to Volume 22 Metal Ions in Bio-Imaging Techniques ix
  5. Contents xiii
  6. Contributors to Volume 22 xix
  7. Titles of Volumes 1–44 in the Metal Ions in Biological Systems Series xxiii
  8. Contents of Volumes in the Metal Ions in Life Sciences Series xxv
  9. 1 Metal Ions in Bio-Imaging Techniques: A Short Overview 1
  10. 2 Gadolinium(III)-Based Contrast Agents for Magnetic Resonance Imaging. A Re-Appraisal 39
  11. 3 Manganese Complexes as Contrast Agents for Magnetic Resonance Imaging 71
  12. 4 Metal Ion Complexes in Paramagnetic Chemical Exchange Saturation Transfer (ParaCEST) 101
  13. 5 Lanthanide Complexes Used for Optical Imaging 137
  14. 6 Radiometals for Positron Emission Tomography (PET) Imaging 157
  15. 7 99mTechnetium-Based Imaging Agents and Developments in 99Tc Chemistry 195
  16. 8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging 239
  17. 9 Iron Oxide Nanoparticles for Bio-Imaging 271
  18. 10 Magnetic Resonance Contrast Enhancement and Therapeutic Properties of Corrole Nanoparticles 299
  19. 11 Positron Emission Tomography (PET) Driven Theranostics 315
  20. 12 Magnetic Resonance Theranostics: An Overview of Gadolinium(III)-Based Strategies and Magnetic Particle Imaging 347
  21. 13 Luminescence Imaging of Cancer Cells 371
  22. 14 Iridium(III) Complexes in Bio-Imaging Including Mitochondria 403
  23. 15 Imaging Bacteria with Contrast-Enhanced Magnetic Resonance 425
  24. 16 Transition Metals and Imaging Probes in Neurobiology and Neurodegenerative Diseases 437
  25. 17 Heavy Elements for X-Ray Contrast 457
  26. Subject Index 485
Downloaded on 11.5.2026 from https://www.degruyterbrill.com/document/doi/10.1515/9783110685701-015/html?lang=en
Scroll to top button