Ginger Modulates Lymphocyte Activity in Vitro and in Vivo and Modestly Prolongs Cardiac Allograft Survival
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Chumpon Wilasrusmee
Objectives: Ginger, an herb with diverse pharmacotherapeutic properties, is used as an anti-inflammatory agent in immunological disorders like rheumatoid arthritis. The objective of the present investigation was to study the effect of ginger on alloreactivity and on prolongation of cardiac allograft in mice.Design: We tested the effect of ginger extract on lymphocytes in vitro and in vivo and the response of ginger treated lymphocytes to allostimulation and cytosine release. We also studied the effect of ginger extract on cardiac allograft survival in a non vascularized transplantation model in mice.Results: We observed an immunosuppressive effect of ginger in vitro and in vivo. Ginger extract decreased lymphocyte proliferation in response to allostimulation. Ginger extract also decreased the production of the immunostimulatory cytokines IL-2, IL-4 and IFN-? and increased the production of the immunomudulatory cytokines IL-10 and TGF?1. Ginger extract by itself produced a modest increase in the survival of cardiac allografts in mice survival.Conclusion: Our study demonstrates that ginger extract has immunosuppressive effects both in vitro on lymphocyte proliferation and cytokine production and in vivo on allograft survival.
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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- Discussion Paper
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Articles in the same Issue
- Review Article
- Pharmacology of Huperzine A, an Alkaloid Isolated from Huperzine Serrata, a Novel Cognition Enhancer with Dual Cholinergic and NMDA Action. Implications in Schizophrenia and Dementia
- Research Article
- Fuzzy Rule Based Systems in Classification of Terminalia Chebula Fruits of Complementary and Alternative Medicine
- A Natural, Multi-Mechanistic Supplement Approach for Improving Cardiovascular Risk Factors
- How Do Private CAM Therapies Affect Integrative Health Care Settings in a Publicly Funded Health Care System?
- Preventive Effects of an Extract of Erythrina Lysistemon (Fabaceae) on Some Menopausal Problems: Studies on the Rat
- Bridge Building and Integrative Treatment of People with Multiple Sclerosis. Research-based Evaluation of a Team-building Process
- The Effects of Honey Compared With Sucrose and a Sugar-free Diet on Neutrophil Phagocytosis and Lymphocyte Numbers after Long-term Feeding in Rats
- Effect of Andrographolide on Monkey Hepatocytes against Galactosamine Induced Cell Toxicity : An In-Vitro Study
- Ginger Modulates Lymphocyte Activity in Vitro and in Vivo and Modestly Prolongs Cardiac Allograft Survival
- Discussion Paper
- Orthodox Use, or Misuse, of Complementary & Alternative Medicine
- Using the Behavioral Model for Complementary and Alternative Medicine: The CAM Healthcare Model
- Conference Presentation
- Coming of Age -- Emerging Issues and New Directions in CAM Research: Abstracts from the Fourth Annual IN-CAM Symposium November 1 & 2, 2007, Vancouver, Canada
