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Pharmacology of Huperzine A, an Alkaloid Isolated from Huperzine Serrata, a Novel Cognition Enhancer with Dual Cholinergic and NMDA Action. Implications in Schizophrenia and Dementia
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Simon S Chiu
Published/Copyright:
April 15, 2007
Recently, there has been an escalating interest in exploring novel pharmacological approaches in Alzheimer Dementia and Schizophrenia. We reviewed the pharmacology of Huperzine A, an alkaloid isolated from Huperzia Serrata. The dual action of Huperzine in inhibiting cholinesterase activity and modulating the excitatory amino acid neurotransmitter NMDA (N-methyl-D-aspartic acid) makes the compound highly appealing as target in pharmaceutical development as a cognitive enhancer agent.
Published Online: 2007-4-15
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Articles in the same Issue
- Review Article
- Pharmacology of Huperzine A, an Alkaloid Isolated from Huperzine Serrata, a Novel Cognition Enhancer with Dual Cholinergic and NMDA Action. Implications in Schizophrenia and Dementia
- Research Article
- Fuzzy Rule Based Systems in Classification of Terminalia Chebula Fruits of Complementary and Alternative Medicine
- A Natural, Multi-Mechanistic Supplement Approach for Improving Cardiovascular Risk Factors
- How Do Private CAM Therapies Affect Integrative Health Care Settings in a Publicly Funded Health Care System?
- Preventive Effects of an Extract of Erythrina Lysistemon (Fabaceae) on Some Menopausal Problems: Studies on the Rat
- Bridge Building and Integrative Treatment of People with Multiple Sclerosis. Research-based Evaluation of a Team-building Process
- The Effects of Honey Compared With Sucrose and a Sugar-free Diet on Neutrophil Phagocytosis and Lymphocyte Numbers after Long-term Feeding in Rats
- Effect of Andrographolide on Monkey Hepatocytes against Galactosamine Induced Cell Toxicity : An In-Vitro Study
- Ginger Modulates Lymphocyte Activity in Vitro and in Vivo and Modestly Prolongs Cardiac Allograft Survival
- Discussion Paper
- Orthodox Use, or Misuse, of Complementary & Alternative Medicine
- Using the Behavioral Model for Complementary and Alternative Medicine: The CAM Healthcare Model
- Conference Presentation
- Coming of Age -- Emerging Issues and New Directions in CAM Research: Abstracts from the Fourth Annual IN-CAM Symposium November 1 & 2, 2007, Vancouver, Canada
