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The importance of the negative blood-oxygenation-level-dependent (BOLD) response in the somatosensory cortex

  • Carsten M. Klingner EMAIL logo , Stefan Brodoehl and Otto W. Witte
Published/Copyright: June 9, 2015
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Abstract

In recent years, multiple studies have shown task-induced negative blood-oxygenation-level-dependent responses (NBRs) in multiple brain regions in humans and animals. Converging evidence suggests that task-induced NBRs can be interpreted in terms of decreased neuronal activity. However, the vascular and metabolic dynamics and functional importance of the NBR are highly debated. Here, we review studies investigating the origin and functional importance of the NBR, with special attention to the somatosensory cortex.


Corresponding author: Carsten M. Klingner, Hans Berger Clinic for Neurology, University Hospital Jena, Friedrich Schiller University, Erlanger Allee 101, D-07747 Jena, Germany, e-mail:

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Received: 2015-1-22
Accepted: 2015-4-17
Published Online: 2015-6-9
Published in Print: 2015-12-1

©2015 by De Gruyter

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