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Green synthesis of MnFe2O4 nanoparticles using Elaeis guineensis Jacq. leaves and empty fruit bunches extract and its radiolabeling with 99mTc as a potential agent for dual-modality imaging SPECT/MRI

  • Amal Rezka Putra ORCID logo , Muhammad Dzaki Fadhlurrohman , Miftakul Munir ORCID logo , Sumandi Juliyanto ORCID logo , Ahsanal Fikri , Ilma Darojatin , Wening Lestari , Veronika Y. Susilo , Alfian Mahardika Forentin , Muhamad Basit Febrian , Andi Arjuna , Nuri Jannati Wahyu Ekaningsih , Lira Aprilia Pujianti ORCID logo , Dewangga Oky Bagus Apriandanu , Rien Ritawidya and Yoki Yulizar EMAIL logo
Published/Copyright: July 9, 2025
Radiochimica Acta
From the journal Radiochimica Acta Volume 113 Issue 9

Abstract

This study aimed to develop a novel material for dual-modality SPECT/MRI. MnFe2O4 nanoparticles (NPs) were synthesized via a green method using Elaeis guineensis Jacq. extracts (leaf extract – ELE and empty fruit bunches extract – EFBE) at an optimal calcination temperature of 400 °C. Characterization by FTIR, XRD, SEM, TEM, SAED, TGA, and VSM revealed NPs with an average size of 28.6 ± 9.6 nm and a magnetization value of 38.2 emu/g. The optimal conjugation with human serum albumin (HSA) was achieved at a 1:1 ratio, yielding approximately 0.388 ± 0.049 mg per mg of HSA. Radiolabeling of [99mTc]Tc-HSA-MnFe2O4 NPs was characterized using HPLC and TLC to assess impurities, demonstrating radiochemical purity exceeding 99 % across various media, including PBS, saline, water and human serum. Further studies are necessary to evaluate the biological profiles using in vitro and in vivo assays.

Keywords: MnFe2O4 nanoparticles; Elaeis guineensis Jacq.; human serum albumin (HSA); [99mTc]Tc-HSA-MnFe2O4 NPs
Corresponding author: Yoki Yulizar, Faculty of Mathematics and Natural Sciences, Department of Chemistry, Universitas Indonesia, Depok, Jawa Barat 16424, Indonesia, E-mail:

Acknowledgments

All authors discussed the results and implications and commented on the manuscript at all stages. The authors also acknowledge the facilities, scientific, and technical support provided by the Advanced Characterization Physics Laboratories, and the Radioisotope and Radiopharmaceutical Installation, National Research and Innovation Agency, through E-Layanan Sains, BRIN.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors contributed equally to this work. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Use of Large Language Models, AI and Machine Learning Tools: Trinka AI (https://www.trinka.ai/) was used to assist in grammar checking and enhancing the language quality of this manuscript.

  5. Conflict of interest: The authors state no conflict of interest.

  6. Research funding: This study was supported by the National Research and Innovation Agency (BRIN) through the Postgraduate Research-Based Program under Decree No. 111/II/HK/2023, organized by the Deputy for Human Resources of Science and Technology, and the Program for the Prototype of Nanotechnology and Advanced Materials, Project No. 3/III.10/HK/2023 (Code No: 31), organized by the Nanotechnology and Materials Research Organization.

  7. Data availability: Not applicable.

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Received: 2024-11-12
Accepted: 2025-05-30
Published Online: 2025-07-09
Published in Print: 2025-09-25

© 2025 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Separation and purification of Zr from a low-temperature LiCl–KCl–CsCl eutectic by the formation of dendritic crystal
  4. Particle-reinforced ion exchange resin for selective separation and recovery of cesium from highly acidic water
  5. Green synthesis of MnFe2O4 nanoparticles using Elaeis guineensis Jacq. leaves and empty fruit bunches extract and its radiolabeling with 99mTc as a potential agent for dual-modality imaging SPECT/MRI
  6. Mn(II) and Cu(II) metal complexes with bisamine based bidentate ligand. Spectroscopic investigation, biological activity and gamma ray irradiation impact
  7. Synergistic influence of carbon black and montmorillonite nano clay on mechanical, electrical, and acoustic properties of nitrile butadiene rubber nanocomposites via gamma radiation
  8. Erbium-borate modified glass with lead and barium: new composite materials for gamma ray shielding
  9. Gamma and neutron radiation shielding properties of Al2O3–B2O3–SiO2–ZnO–BaO glasses
https://doi.org/10.1515/ract-2024-0368
Keywords for this article
MnFe2O4 nanoparticles; Elaeis guineensis Jacq.; human serum albumin (HSA); [99mTc]Tc-HSA-MnFe2O4 NPs

Articles in the same Issue

  1. Frontmatter
  2. Original Papers
  3. Separation and purification of Zr from a low-temperature LiCl–KCl–CsCl eutectic by the formation of dendritic crystal
  4. Particle-reinforced ion exchange resin for selective separation and recovery of cesium from highly acidic water
  5. Green synthesis of MnFe2O4 nanoparticles using Elaeis guineensis Jacq. leaves and empty fruit bunches extract and its radiolabeling with 99mTc as a potential agent for dual-modality imaging SPECT/MRI
  6. Mn(II) and Cu(II) metal complexes with bisamine based bidentate ligand. Spectroscopic investigation, biological activity and gamma ray irradiation impact
  7. Synergistic influence of carbon black and montmorillonite nano clay on mechanical, electrical, and acoustic properties of nitrile butadiene rubber nanocomposites via gamma radiation
  8. Erbium-borate modified glass with lead and barium: new composite materials for gamma ray shielding
  9. Gamma and neutron radiation shielding properties of Al2O3–B2O3–SiO2–ZnO–BaO glasses
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