Chitosan nanoparticles encapsulated into PLA/gelatin fibers for bFGF delivery
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Niloofar Ghasemzaie
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Hassan Niknejad
Abstract
Electrospinning is a trendy method because of the ease of use and the high surface-to-volume ratio. The mechanical and biological properties of polylactic acid (PLA) make it one of the most enticing polymers. Gelatin and PLA together are thought to enhance cellular behavior and hydrophilicity of scaffolds. Furthermore, chitosan nanoparticles (CNPs) can be incorporated into PLA fibers to achieve controlled growth factor release. This study utilized PLA–gelatin nanofibrous scaffolds in which CNPs were encapsulated within PLA fibers to achieve a controlled release of basic fibroblast growth factor (bFGF). To produce CNPs, a simple ionic gelation reaction was used. The optimal diameter of CNPs was determined by investigating chitosan to tricalciumphosphatesodium (TPP) ratio and TPP concentration. Using a spectrophotometer, we measured the release rate of bFGF from CNPS and scaffolds. Images from a scanning electron microscope (SEM) were used to assess the effect of various concentrations of PLA and gelatin on fiber diameter. The results showed that PLA–gelatin scaffolds could stimulate the release of growth factors and promote cell proliferation. Using a two-jet electrospinning device to produce PLA–gelatin fibers in combination with CNPs incorporated within PLA fibers to release the bFGF growth factor is the novelty of this study.
Acknowledgments
The authors would like to thank Mrs. Sara Azizian and Mr. Khashayar modaresifar for their help in this study.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- Dynamic characterization of the magnetomechanical properties of off axis anisotropic magnetorheological elastomer
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- Chitosan nanoparticles encapsulated into PLA/gelatin fibers for bFGF delivery
- Engineering and Processing
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Articles in the same Issue
- Frontmatter
- Material properties
- Research progress of low dielectric constant polymer materials
- Natural rubber reinforced with super-hydrophobic multiwalled carbon nanotubes: obvious improved abrasive resistance and enhanced thermal conductivity
- Epoxy resin/graphene nanoplatelets composites applied to galvanized steel with outstanding microwave absorber performance
- Enhancement of thermal conductivity in polymer composites by maximizing surface-contact area of polymer-filler interface
- Dynamic characterization of the magnetomechanical properties of off axis anisotropic magnetorheological elastomer
- Investigation of optical and biocompatible properties of polyethylene glycol-aspirin loaded commercial pure titanium for cardiovascular device applications
- Polylactic acid effectively reinforced with reduced graphitic oxide
- Preparation and assembly
- Assembled hybrid films based on sepiolite, phytic acid, polyaspartic acid and Fe3+ for flame-retardant cotton fabric
- Fabrication, characterization, and performance of poly (aryl ether nitrile) flat sheet ultrafiltration membranes with polyvinyl pyrrolidone as additives
- Synthesis of composite membranes from polyacrylonitrile/carbon resorcinol/formaldehyde xerogels: gamma effect study, characterization and ultrafiltration of salted oily wastewater
- Chitosan nanoparticles encapsulated into PLA/gelatin fibers for bFGF delivery
- Engineering and Processing
- Stable photoluminescent electrospun CdSe/CdS quantum dots-doped polyacrylonitrile composite nanofibers
