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Investigation of optical and biocompatible properties of polyethylene glycol-aspirin loaded commercial pure titanium for cardiovascular device applications

  • Monalisha Mohanta and A. Thirugnanam EMAIL logo
Published/Copyright: May 31, 2022
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Journal of Polymer Engineering
From the journal Journal of Polymer Engineering Volume 42 Issue 8

Abstract

This research investigates the optical and biocompatible properties of alkali-treated cpTi immersed in aspirin and different molecular weights of polyethylene (PEG). Instrumental characterizations were performed using scanning electron microscopy (SEM), Raman spectroscopy, and ultraviolet–visible spectroscopy. Additionally, drug release, antithrombotic, and cell adhesion studies were conducted in in-vitro conditions. The SEM micrographs showed that heat treatment of NaOH modified cpTi substrates increased the average surface pore size by 217%. Raman spectra’s active modes confirmed the presence of titanate groups which intensified the semiconductive nature of alkali-treated cpTi substrates. Further, the semiconductive nature was confirmed through the shift of the energy bandgap from 2.69 to 2.9 eV. The continuous redshift of the absorbance edge with an increase in the molecular weight of PEG indicates improved optical property. Following the Rigter–Peppas dynamic model, the drug release kinetics showed a non-Fickian dispersion (n < 1) and super case II transport (n = 2.21) for PEG-coated cpTi substrates. The alkali-treated cpTi-aspirin-PEG surface exhibits suitable antithrombotic property and interstitial cell adhesion with PEG coating. The modified surface on cpTi demonstrated a promising technique to improve the optical, antithrombotic, and biocompatibility performances, which are the prime requirement for the blood-interacted cardiovascular devices such as stents.

Keywords: biocompatibility; commercial pure titanium; drug release study; energy bandgap; polyethylene glycol
Corresponding author: A. Thirugnanam, Department of Biotechnology & Medical Engineering, National Institute of Technology Rourkela, Rourkela, Odisha, 769008, India, E-mail:

Funding source: National Institute of Technology Rourkela

Award Identifier / Grant number: Unassigned

Acknowledgments

The authors thank MIDHANI, Hyderabad, India, for supplying Titanium material and the Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, India, for providing research facilities.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare that they have no conflicts of interest regarding this article.

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Received: 2022-01-22
Accepted: 2022-04-05
Published Online: 2022-05-31
Published in Print: 2022-09-27

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/polyeng-2021-0377
Keywords for this article
biocompatibility; commercial pure titanium; drug release study; energy bandgap; polyethylene glycol

Articles in the same Issue

  1. Frontmatter
  2. Material properties
  3. Research progress of low dielectric constant polymer materials
  4. Natural rubber reinforced with super-hydrophobic multiwalled carbon nanotubes: obvious improved abrasive resistance and enhanced thermal conductivity
  5. Epoxy resin/graphene nanoplatelets composites applied to galvanized steel with outstanding microwave absorber performance
  6. Enhancement of thermal conductivity in polymer composites by maximizing surface-contact area of polymer-filler interface
  7. Dynamic characterization of the magnetomechanical properties of off axis anisotropic magnetorheological elastomer
  8. Investigation of optical and biocompatible properties of polyethylene glycol-aspirin loaded commercial pure titanium for cardiovascular device applications
  9. Polylactic acid effectively reinforced with reduced graphitic oxide
  10. Preparation and assembly
  11. Assembled hybrid films based on sepiolite, phytic acid, polyaspartic acid and Fe3+ for flame-retardant cotton fabric
  12. Fabrication, characterization, and performance of poly (aryl ether nitrile) flat sheet ultrafiltration membranes with polyvinyl pyrrolidone as additives
  13. Synthesis of composite membranes from polyacrylonitrile/carbon resorcinol/formaldehyde xerogels: gamma effect study, characterization and ultrafiltration of salted oily wastewater
  14. Chitosan nanoparticles encapsulated into PLA/gelatin fibers for bFGF delivery
  15. Engineering and Processing
  16. Stable photoluminescent electrospun CdSe/CdS quantum dots-doped polyacrylonitrile composite nanofibers
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