Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus
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Eva Elizabet Camarena Pulido
,
Salvador Mora González
Abstract
Objectives
The frequency of GDM and vitamin D insufficiency in Mexico is high. Vitamin D supplementation in GDM patients has shown favorable but non-homogeneous results regarding improvement of glycemic profile. The aim of the study was to assess the effects of supplementing with 5,000 IU of vitamin D on the glycemic profile of women with GDM.
Methods
A randomized clinical trial was conducted on women with GDM who received 5,000 IU of vitamin D (n=27) or a placebo (n=27) for eight weeks. Changes in vitamin D levels and metabolic parameters before and after the intervention were analyzed.
Results
Vitamin D vs. placebo: 25-OHD (32 vs. 26 ng/mL, p=0.006), HbA1c (6.0 vs. 6.1%, p=0.29), glucose (99 vs. 87 mg/dL, p=0.29), insulin (14 vs. 13 µIU/mL, p=0.79), HOMA-IR (3.6 vs. 2.6, p=0.55), QUICKI (0.31 vs. 0.33, p=0.55).
Conclusions
Supplementation with 5,000 IU of vitamin D for eight weeks had no significant effect on the glycemic profile.
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Research funding: None declared.
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Author contributions: Camarena Pulido Eva E., Mora González Salvador, Corona Gutiérrez América A., Robledo Aceves Mireya, Basso Barba Paola and Salgado Leyva Yunuen contributed equally to this work. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The protocol was approved by the Ethics and Research Committee of the Hospital Civil of Guadalajara and registered with the General Directorate of Public Health ID: DGSP/DDID/D. INV74/18.
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Data availability: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Clinical trial registration: ClinicalTrials.gov, www.clinicaltrials.gov, NTC03645109.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- Mini Review
- The use of neurally-adjusted ventilatory assist (NAVA) for infants with congenital diaphragmatic hernia (CDH)
- Opinion Paper
- The role of specialist perinatal psychiatrists in modern medicine
- Corner of Academy
- Maternal perception of fetal movements: onset and associated factors
- Original Articles – Obstetrics
- Cervical ripening as an outpatient procedure in the pandemic – minimizing the inpatient days and lowering the socioeconomic costs
- Can sonographic imaging of the fetal pancreas predict perinatal outcomes in gestational diabetes mellitus?
- Comparison of transvaginal sonographic cervical length measurement and Bishop score for predicting labour induction outcomes
- Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
- Effect of anesthesia selection on neonatal outcomes in cesarean hysterectomies for placenta accreta spectrum (PAS)
- Bile-acid levels and lung maturity test in patients with intrahepatic cholestasis of pregnancy
- Evaluation of appropriate vancomycin prescribing for the prevention of newborn group B streptococcal infections in a community hospital obstetrics service
- Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus
- Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with vitamin B12 deficiency and adverse perinatal outcomes among pregnant women of rural South India – a cross sectional longitudinal study
- Original Article – Fetus
- Fetal autopsy for the diagnosis of skeletal dysplasia and comparison with prenatal ultrasound findings over a 16-year period
- Original Articles – Neonates
- Neonatal admission rate after vaginal breech delivery
- Extremely low gestational age neonates and resuscitation: survey on perspectives of Canadian neonatologists
- The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women
- Letters to the Editor
- Aspirin for the prevention of preeclampsia
- Reply to: Aspirin for the prevention of preeclampsia
- Total bile acid levels for clinically suspected intrahepatic cholestasis of pregnancy
- Reply: Neonatal lung injury with intrahepatic cholestasis of pregnancy
- Marijuana and pregnancy: just because its legal doesn’t make it safe
- Corrigenda
- Stillbirth aftercare in a tertiary obstetric center–parents’ experiences
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Articles in the same Issue
- Frontmatter
- Review
- Obstetric hemorrhage: effective methods for addressing the menace in Sub-Saharan Africa
- Mini Review
- The use of neurally-adjusted ventilatory assist (NAVA) for infants with congenital diaphragmatic hernia (CDH)
- Opinion Paper
- The role of specialist perinatal psychiatrists in modern medicine
- Corner of Academy
- Maternal perception of fetal movements: onset and associated factors
- Original Articles – Obstetrics
- Cervical ripening as an outpatient procedure in the pandemic – minimizing the inpatient days and lowering the socioeconomic costs
- Can sonographic imaging of the fetal pancreas predict perinatal outcomes in gestational diabetes mellitus?
- Comparison of transvaginal sonographic cervical length measurement and Bishop score for predicting labour induction outcomes
- Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
- Effect of anesthesia selection on neonatal outcomes in cesarean hysterectomies for placenta accreta spectrum (PAS)
- Bile-acid levels and lung maturity test in patients with intrahepatic cholestasis of pregnancy
- Evaluation of appropriate vancomycin prescribing for the prevention of newborn group B streptococcal infections in a community hospital obstetrics service
- Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus
- Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with vitamin B12 deficiency and adverse perinatal outcomes among pregnant women of rural South India – a cross sectional longitudinal study
- Original Article – Fetus
- Fetal autopsy for the diagnosis of skeletal dysplasia and comparison with prenatal ultrasound findings over a 16-year period
- Original Articles – Neonates
- Neonatal admission rate after vaginal breech delivery
- Extremely low gestational age neonates and resuscitation: survey on perspectives of Canadian neonatologists
- The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women
- Letters to the Editor
- Aspirin for the prevention of preeclampsia
- Reply to: Aspirin for the prevention of preeclampsia
- Total bile acid levels for clinically suspected intrahepatic cholestasis of pregnancy
- Reply: Neonatal lung injury with intrahepatic cholestasis of pregnancy
- Marijuana and pregnancy: just because its legal doesn’t make it safe
- Corrigenda
- Stillbirth aftercare in a tertiary obstetric center–parents’ experiences
- Prospective risk of stillbirth according to fetal size at term
