Home Medicine The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women
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The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women

  • Maryam Kasraeian , Nasrin Asadi , Homeira Vafaei , Mahin Tazang , Azam Faraji , Neda Rahimirad , Sedighe Yousofi , Seyedeh Fatemeh Khaleghi and Marjan Zare ORCID logo EMAIL logo
Published/Copyright: May 27, 2022
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 50 Issue 9

Abstract

Objectives

Preterm birth (PTB) is the common cause of neonatal mortality nationwide. The present study aimed to evaluate the efficacy of different doses of aspirin in preventing PTB in high-risk pregnant women. As secondary outcomes, other perinatal complications were compared.

Methods

This double-blind randomized clinical trial was conducted on high-risk pregnant women with impaired placental perfusion diagnosed in the first trimester of pregnancy referring to the perinatal centers affiliated to Shiraz university of Medical Sciences between February 2020 and March 2021. The subjects were randomly divided in two groups administered with 150 or 80 mg aspirin every night from 11 to 13+6 weeks until 36 weeks or delivery. This study is registered in the Iranian Registry of Clinical Trials (IRCT20140317017035N6; http://www.irct.ir/). Univariate and multiple logistic regressions were applied using SPSS 22.

Results

A total of 101 subjects received 80 mg aspirin and 89 ones received 150 mg aspirin. The results of multiple analysis revealed a significantly lower odds of PTB (OR 0.4 (0.19, 0.99)) in the 150 mg group compared to the 80 mg group. As secondary outcomes, preeclampsia (PEC) and PEC with severe features (PECsf) were lower (OR 0.2 (0.06, 0.82) and 0.1 (0.01, 0.92), respectively); however, fetal age and neonatal weight were higher in the 150 mg group (OR 1.2 (1.04, 1.33) and 1.001 (1–1.001), respectively).

Conclusions

The study findings indicated that, compared with 80 mg of aspirin, taking 150 mg of aspirin reduced PTB and perinatal complications in high risk pregnant women.

Keywords: aspirin; clinical trial; pregnancy; preterm birth
Corresponding author: Marjan Zare, Maternal-fetal medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: All study steps were in agreement with the Helsinki Declaration 1964 (IR.SUMS.MED.REC.1398.512). The study was also registered in the Iranian Registry of Clinical Trials (IRCT20140317017035N6; http://www.irct.ir/).

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2021-0668).

Received: 2021-12-15
Revised: 2022-04-27
Accepted: 2022-04-30
Published Online: 2022-05-27
Published in Print: 2022-11-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Obstetric hemorrhage: effective methods for addressing the menace in Sub-Saharan Africa
  4. Mini Review
  5. The use of neurally-adjusted ventilatory assist (NAVA) for infants with congenital diaphragmatic hernia (CDH)
  6. Opinion Paper
  7. The role of specialist perinatal psychiatrists in modern medicine
  8. Corner of Academy
  9. Maternal perception of fetal movements: onset and associated factors
  10. Original Articles – Obstetrics
  11. Cervical ripening as an outpatient procedure in the pandemic – minimizing the inpatient days and lowering the socioeconomic costs
  12. Can sonographic imaging of the fetal pancreas predict perinatal outcomes in gestational diabetes mellitus?
  13. Comparison of transvaginal sonographic cervical length measurement and Bishop score for predicting labour induction outcomes
  14. Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
  15. Effect of anesthesia selection on neonatal outcomes in cesarean hysterectomies for placenta accreta spectrum (PAS)
  16. Bile-acid levels and lung maturity test in patients with intrahepatic cholestasis of pregnancy
  17. Evaluation of appropriate vancomycin prescribing for the prevention of newborn group B streptococcal infections in a community hospital obstetrics service
  18. Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus
  19. Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with vitamin B12 deficiency and adverse perinatal outcomes among pregnant women of rural South India – a cross sectional longitudinal study
  20. Original Article – Fetus
  21. Fetal autopsy for the diagnosis of skeletal dysplasia and comparison with prenatal ultrasound findings over a 16-year period
  22. Original Articles – Neonates
  23. Neonatal admission rate after vaginal breech delivery
  24. Extremely low gestational age neonates and resuscitation: survey on perspectives of Canadian neonatologists
  25. The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women
  26. Letters to the Editor
  27. Aspirin for the prevention of preeclampsia
  28. Reply to: Aspirin for the prevention of preeclampsia
  29. Total bile acid levels for clinically suspected intrahepatic cholestasis of pregnancy
  30. Reply: Neonatal lung injury with intrahepatic cholestasis of pregnancy
  31. Marijuana and pregnancy: just because its legal doesn’t make it safe
  32. Corrigenda
  33. Stillbirth aftercare in a tertiary obstetric center–parents’ experiences
  34. Prospective risk of stillbirth according to fetal size at term
https://doi.org/10.1515/jpm-2021-0668
Keywords for this article
aspirin; clinical trial; pregnancy; preterm birth

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Obstetric hemorrhage: effective methods for addressing the menace in Sub-Saharan Africa
  4. Mini Review
  5. The use of neurally-adjusted ventilatory assist (NAVA) for infants with congenital diaphragmatic hernia (CDH)
  6. Opinion Paper
  7. The role of specialist perinatal psychiatrists in modern medicine
  8. Corner of Academy
  9. Maternal perception of fetal movements: onset and associated factors
  10. Original Articles – Obstetrics
  11. Cervical ripening as an outpatient procedure in the pandemic – minimizing the inpatient days and lowering the socioeconomic costs
  12. Can sonographic imaging of the fetal pancreas predict perinatal outcomes in gestational diabetes mellitus?
  13. Comparison of transvaginal sonographic cervical length measurement and Bishop score for predicting labour induction outcomes
  14. Regional differences in utilization of 17α-hydroxyprogesterone caproate (17-OHP)
  15. Effect of anesthesia selection on neonatal outcomes in cesarean hysterectomies for placenta accreta spectrum (PAS)
  16. Bile-acid levels and lung maturity test in patients with intrahepatic cholestasis of pregnancy
  17. Evaluation of appropriate vancomycin prescribing for the prevention of newborn group B streptococcal infections in a community hospital obstetrics service
  18. Effect of supplementation with 5,000 IU of vitamin D on the glycemic profile of women with gestational diabetes mellitus
  19. Association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with vitamin B12 deficiency and adverse perinatal outcomes among pregnant women of rural South India – a cross sectional longitudinal study
  20. Original Article – Fetus
  21. Fetal autopsy for the diagnosis of skeletal dysplasia and comparison with prenatal ultrasound findings over a 16-year period
  22. Original Articles – Neonates
  23. Neonatal admission rate after vaginal breech delivery
  24. Extremely low gestational age neonates and resuscitation: survey on perspectives of Canadian neonatologists
  25. The effect of 150 and 80 mg doses of aspirin on preventing preterm birth in high-risk pregnant women
  26. Letters to the Editor
  27. Aspirin for the prevention of preeclampsia
  28. Reply to: Aspirin for the prevention of preeclampsia
  29. Total bile acid levels for clinically suspected intrahepatic cholestasis of pregnancy
  30. Reply: Neonatal lung injury with intrahepatic cholestasis of pregnancy
  31. Marijuana and pregnancy: just because its legal doesn’t make it safe
  32. Corrigenda
  33. Stillbirth aftercare in a tertiary obstetric center–parents’ experiences
  34. Prospective risk of stillbirth according to fetal size at term
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