Disparity in post-treatment maternal circulating magnesium sulfate levels between twin and singleton gestation: Is this the missing link between plurality and adverse outcome?

References

[1] Bain E, Middleton P, Crowther CA. Different magnesium sulphate regimens for neuroprotection of the fetus for women at risk of preterm birth. Cochrane Database Syst Rev. 2012;2:CD009302.Search in Google Scholar

[2] Blondel B, Kogan MD, Alexander GR, Dattani N, Kramer MS, Macfarlane A, et al. The impact of increasing number of multiple births on the rates of preterm birth and low birthweight: an international study. Am J Public Health 2002;92:1323–30.Search in Google Scholar

[3] Brubaker SG, Gyamfi C. Prediction and prevention of spontaneous preterm birth in twin gestations. Semin Perinatol. 2012;36:190–4.Search in Google Scholar

[4] Conde-Agudelo A, Romero R. Antenatal magnesium sulfate for the prevention of cerebral palsy in preterm infants less than 34 weeks’ gestation: a systematic review and metaanalysis. Am J Obstet Gynecol. 2009;200:595–609.Search in Google Scholar

[5] Crowther CA, Hiller JE, Doyle LW, Haslam RR; Australasian Collaborative Trial of Magnesium Sulphate (ACTOMg SO4) Collaborative Group. Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. J Am Med Assoc. 2003;290:2669–76.Search in Google Scholar

[6] Cuminis SK, Nelson KB, Grether JK, Velie EM. Cerebral palsy in four northern California counties, births 1983 through 1985. J Pediatr. 1993;123:230–7.Search in Google Scholar

[7] Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse DJ, Spong CY. Pregnancy hypertension: Williams obstetrics, 23rd ed. New York: McGraw-Hill, 2010.Search in Google Scholar

[8] Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D. Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev. 2009;21:CD004661.Search in Google Scholar

[9] Elliott JP, Radin TG. Serum magnesium levels during magnesium sulfate tocolysis in high-order multiple gestations. J Reprod Med. 1995;40:450–2.Search in Google Scholar

[10] Fonseca EB, Celik E, Parra M, Singh M, Nicolaides KH. Fetal Medicine Foundation Second Trimester Screening Group. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007;357:462–9.Search in Google Scholar

[11] Hassan SS, Romero R, Vidyadhari D, Fusey S, Baxter JK, Khandelwal M, et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2011;38:18–31.Search in Google Scholar

[12] Himpens E, Van den Broek C, Costra A, Calders P, Vanhaesebrouck P. Prevalence, type, distribution, and severity of cerebral palsy in relation to gestational age: a meta-analytic review. Dev Med Child Neurol. 2008;50:334–40.Search in Google Scholar

[13] Kametas NA, McAuliffe F, Krampl E, Chambers J, Nicolaides KH. Maternal cardiac function in twin pregnancy. Obstet Gynecol. 2003;102:806–15.Search in Google Scholar

[14] Kiely JL. What is the population-based risk of preterm birth among twins and other multiples? Clin Obstet Gynecol. 1998;41:3–11.Search in Google Scholar

[15] Marret S, Marpeau L, Follet-Bouhamed C, Cambonie G, Astruc D, et al.; le groupe PREMAG. Effect of magnesium sulphate on mortality and neurologic morbidity of the very-preterm newborn (of less than 33 weeks) with two-year neurological outcome: results of the prospective PREMAG trial. Gynecol Obstet Fertil. 2008;36:278–88.Search in Google Scholar

[16] Mason BA, Standley CA, Whitty JE, Cotton DB. Fetal ionized magnesium levels parallel maternal levels during magnesium sulfate therapy for preeclampsia. Am J Obstet Gynecol 1996;175:213–7.Search in Google Scholar

[17] Meis PJ, Klebanoff M, Thom E, Dombrowski MP, Sibai B, Moawad AH, et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 2003;348:2379–85.Search in Google Scholar

[18] Mitten R, Pryde P, Lee KS, Besinger R, MacMillan W, Karlman R, et al. 258 Impaired clearance of serum magnesium in the very low birth weight (VLBW, <1500 g) neonate as compared to its mother. Am J Obstet Gynecol. 2001;185:S151.Search in Google Scholar

[19] Norman JE, Mackenzie F, Owen P, Mactier H, Hanretty K, Cooper S, et al. Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT): a randomised, double-blind, placebo-controlled study and meta-analysis. Lancet 2009;373:2034–40.Search in Google Scholar

[20] Pryde PG, Borg MJ, Mittendorf R, Elin RJ. Cord blood ionized magnesium (iMg) levels exceed maternal levels in both untreated and tocolytic magnesium sulfate treated preterm neonates. Am J Obstet Gynecol. 1999;184:S50.Search in Google Scholar

[21] Rode L, Klein K, Nicolaides KH, Krampl-Bettelheim E, Tabor A; PREDICT Group. Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. Ultrasound Obstet Gynecol. 2011;38:272–80.Search in Google Scholar

[22] Romero R, Nicolaides K, Conde-Agudelo A, Tabor A, O’Brien JM, Cetingoz E, et al. Vaginal progesterone in women with an asymptomatic sonographic short cervix in the midtrimester decreases preterm delivery and neonatal morbidity: a systematic review and metaanalysis of individual patient data. Am J Obstet Gynecol. 2012;206:124.e1–19.Search in Google Scholar

[23] Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, et al; Eunice Kennedy Shriver NICHD Maternal-Fetal Medicine Units Network. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med. 2008;359:895–905.Search in Google Scholar

[24] Scher AI, Petterson B, Blair E, Ellenberg JH, Grether JK, Haan E, et al. The risk of mortality or cerebral palsy in twins: a collaborative population-based study. Pediatr Res. 2002;52:671–81.Search in Google Scholar

[25] Vohr BR, Wright LL, Poole WK, McDonald SA. Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks’ gestation between 1993 and 1998. Pediatrics 2005;116:635–43.Search in Google Scholar