Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study
-
Xiaofang Jia
, Masahiro Tagawa , Hiroshi Yatsuya , Hisao Naito , Yumi Hayashi , Husna Yetti , Seiko Sasaki , Atsuko Araki , Chihiro Miyashita , Tamiko Ikeno , Reiko Kishi and Tamie Nakajima
Abstract
Objective: To investigate selected fatty acid (FA) profiles in maternal whole blood during normal pregnancy and to evaluate their associations with term birth dimensions.
Methods: We characterized nine major maternal blood FAs representing four FA families during the second and third trimester of pregnancy, and explored their associations with birth weight, length, and chest or head circumferences by multivariate regression models, using data from 318 mother-newborn pairs of the Hokkaido Study.
Results: The absolute and/or relative contents of maternal blood docosahexaenoic acid and arachidonic acid were lowest at 35–41 gestational weeks during pregnancy, as was the essential FA status index. Different from palmitic and stearic acids, palmitoleic and oleic acid contents were higher at 35–41 gestational weeks than those at 23–31 gestational weeks. Three FA components were identified through principal component analysis, and were used in association analysis. Component 3, which was positively and significantly loaded by eicosapentaenoic acid (EPA), was associated with chest circumference [β=0.281, 95% confidence interval (CI): 0.006, 0.556] at 35–41 gestational weeks (P=0.046). No significant associations were observed for Component 1 and 2 loaded by FAs except EPA.
Conclusion: Maternal blood EPA content may have an important influence on infant chest circumference.
Acknowledgments
This work was funded by Grants-in-Aid for Health Scientific Research from the Japan Society for the Promotion of Science (25253050). Additionally, we would like to thank the medical staff and the participants at Sapporo Toho Hospital, and staff of the “Hokkaido Study on Environment and Children’s Health”. We also thank Ms Aiko Tajima at the Department of Occupational and Environmental Health of Nagoya University Graduate School of Medicine for the maternal blood TG and FA measurements.
References
[1] Guillou H, Zadravec D, Martin PG, Jacobsson A. The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice. Prog Lipid Res. 2010;49:186–99.Search in Google Scholar
[2] Ortega-Senovilla H, Alvino G, Taricco E, Cetin I, Herrera E. Enhanced circulating retinol and non-esterified fatty acids in pregnancies complicated with intrauterine growth restriction. Clin Sci (Lond). 2009;118:351–8.Search in Google Scholar
[3] Al MD, van Houwelingen AC, Kester AD, Hasaart TH, de Jong AE, Hornstra G. Maternal essential fatty acid patterns during normal pregnancy and their relationships to the neonatal essential fatty acid status. Br J Nutr. 1995;74:55–68.Search in Google Scholar
[4] De Vriese SR, Dhont M, Christophe AB. FA composition of cholesteryl esters and phospholipids in maternal plasma during pregnancy and at delivery and in cord plasma at birth. Lipids. 2003;38:1–7.Search in Google Scholar
[5] De Vriese SR, Christophe AB, Maes M. Fatty acid composition of phospholipids and cholesteryl esters in maternal serum in the early puerperium. Prostaglandins Leukot Essent Fatty Acids. 2003;68:331–5.Search in Google Scholar
[6] Matorras R, Ruiz JI, Perteagudo L, Barbazan MJ, Diaz A, Valladolid A, et al. Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy. J Perinat Med. 2001;29:293–7.Search in Google Scholar
[7] Sanjurjo P, Matorras R, Ingunza N, Alonso M, Rodriguez-Alarcon J, Perteagudo L. Cross-sectional study of percentual changes in total plasmatic fatty acids during pregnancy. Horm Metab Res. 1993;25:590–2.Search in Google Scholar
[8] Godfrey KM, Barker DJ. Fetal nutrition and adult disease. Am J Clin Nutr. 2000;71(5 Suppl):1344S–52S.Search in Google Scholar
[9] van Eijsden M, Hornstra G, van der Wal MF, Vrijkotte TG, Bonsel GJ. Maternal n-3, n-6, and trans fatty acid profile early in pregnancy and term birth weight: a prospective cohort study. Am J Clin Nutr. 2008;87:887–95.Search in Google Scholar
[10] Dirix CE, Kester AD, Hornstra G. Associations between neonatal birth dimensions and maternal essential and trans fatty acid contents during pregnancy and at delivery. Br J Nutr. 2009;101:399–407.Search in Google Scholar
[11] Rump P, Mensink RP, Kester AD, Hornstra G. Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. Am J Clin Nutr. 2001;73:797–806.Search in Google Scholar
[12] Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F, Saijo Y, et al. Cohort profile: the Hokkaido study on environment and children’s health in Japan. Int J Epidemiol. 2011;40:611–8.Search in Google Scholar
[13] Konishi K, Sasaki S, Kato S, Ban S, Washino N, Kajiwara J, et al. Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight. Environ Res. 2009;109:906–13.Search in Google Scholar
[14] Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, et al. Correlations between prenatal exposure to perfluorinated chemicals and rediced fetal growth. Environ Health Perspect. 2009;117:660–7.Search in Google Scholar
[15] Nakashima R, Hayashi Y, Md K, Jia X, Wang D, Naito H, et al. Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. Toxicology. 2013;309:52–60.Search in Google Scholar
[16] Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:497–509.Search in Google Scholar
[17] Anderson SG, Sanders TA, Cruickshank JK. Plasma fatty acid composition as a predictor of arterial stiffness and mortality. Hypertension. 2009;53:839–45.Search in Google Scholar
[18] Wheeler SJ, Poston L, Thomas JE, Seed PT, Baker PN, Sanders TA. Maternal plasma fatty acid composition and pregnancy outcome in adolescents. Br J Nutr. 2011;105:601–10.Search in Google Scholar
[19] Agostoni C, Galli C, Riva E, Rise P, Colombo C, Giovannini M, et al. Whole blood fatty acid composition at birth: from the maternal compartment to the infant. Clin Nutr. 2011;30:503–5.Search in Google Scholar
[20] Lauritzen L, Hansen HS, Jorgensen MH, Michaelsen KF. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res. 2001;40:1–94.Search in Google Scholar
[21] Larque E, Demmelmair H, Gil-Sanchez A, Prieto-Sanchez MT, Blanco JE, Pagan A, et al. Placental transfer of fatty acids and fetal implications. Am J Clin Nutr. 2011;94(6 Suppl):1908S–13S.Search in Google Scholar
[22] De Vriese SR, Houwelingen AC, Hornstra G, Dhont M, Christophe AB. The composition of saturated fatty acids in plasma phospholipids changes in a way to counteract changes in the mean melting point during pregnancy. Lipids. 2001;36:15–20.Search in Google Scholar
[23] Al MD, Badart-Smook A, von Houwelingen AC, Hasaart TH, Hornstra G. Fat intake of women during normal pregnancy: relationship with maternal and neonatal essential fatty acid status. J Am Coll Nutr. 1996;15:49–55.Search in Google Scholar
[24] De Vriese SR, De Henauw S, De Backer G, Dhont M, Christophe AB. Estimation of dietary fat intake of Belgian pregnant women: comparison of two methods. Ann Nutr Metab. 2001;45:273–8.Search in Google Scholar
[25] Smits LJ, Elzenga HM, Gemke RJ, Hornstra G, van Eijsden M. The association between interpregnancy interval and birth weight: what is the role of maternal polyunsaturated fatty acid status? BMC Pregnancy Childbirth. 2013;13:23.Search in Google Scholar
[26] Sekikawa A, Shin C, Masaki KH, Barinas-Mitchell EJ, Hirooka N, Willcox BJ, et al. Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, Whites, and Japanese Americans. Am J Hypertens. 2013;26:1321–27.Search in Google Scholar
The authors stated that there are no conflicts of interest regarding the publication of this article.
©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- Risk factors for preterm birth and new approaches to its early diagnosis
- Review
- Avoiding the prenatal programming effects of glucocorticoids: are there alternative treatments for the induction of antenatal lung maturation?
- Original articles – Obstetrics
- The association of first trimester bleeding with preterm delivery
- Cervical sonoelastography for improving prediction of preterm birth compared with cervical length measurement and fetal fibronectin test
- The neuroprotective effect of magnesium sulfate in preterm fetal mice
- Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
- The unborn smoker: association between smoking during pregnancy and adverse perinatal outcomes
- Association of group B streptococcus colonization with early term births
- Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study
- Predicting onset of labor from echogenicity of the cervical gland area on vaginal ultrasonography at term
- Disparity in post-treatment maternal circulating magnesium sulfate levels between twin and singleton gestation: Is this the missing link between plurality and adverse outcome?
- Original articles – Fetus
- Cardiovascular profile score in 44 fetuses with cervicofacial tumors
- First trimester tricuspid regurgitation and fetal abnormalities
- Gastroschisis: incidence and prediction of growth restriction
- Original articles – Newborn
- Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis
- First- and fifth-minute Apgar scores of 0–3 and infant mortality: a population-based study in São Paulo State of Brazil
- Feeding the feeble: steps towards nourishing preterm infants
- Book review
- Hot topics in perinatal medicine
- Erratum
- Erratum to: Impact of the nitric oxide-donor pentaerythrityl-tetranitrate on perinatal outcome in risk pregnancies: a prospective, randomized, double-blinded trial
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Risk factors for preterm birth and new approaches to its early diagnosis
- Review
- Avoiding the prenatal programming effects of glucocorticoids: are there alternative treatments for the induction of antenatal lung maturation?
- Original articles – Obstetrics
- The association of first trimester bleeding with preterm delivery
- Cervical sonoelastography for improving prediction of preterm birth compared with cervical length measurement and fetal fibronectin test
- The neuroprotective effect of magnesium sulfate in preterm fetal mice
- Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
- The unborn smoker: association between smoking during pregnancy and adverse perinatal outcomes
- Association of group B streptococcus colonization with early term births
- Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study
- Predicting onset of labor from echogenicity of the cervical gland area on vaginal ultrasonography at term
- Disparity in post-treatment maternal circulating magnesium sulfate levels between twin and singleton gestation: Is this the missing link between plurality and adverse outcome?
- Original articles – Fetus
- Cardiovascular profile score in 44 fetuses with cervicofacial tumors
- First trimester tricuspid regurgitation and fetal abnormalities
- Gastroschisis: incidence and prediction of growth restriction
- Original articles – Newborn
- Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis
- First- and fifth-minute Apgar scores of 0–3 and infant mortality: a population-based study in São Paulo State of Brazil
- Feeding the feeble: steps towards nourishing preterm infants
- Book review
- Hot topics in perinatal medicine
- Erratum
- Erratum to: Impact of the nitric oxide-donor pentaerythrityl-tetranitrate on perinatal outcome in risk pregnancies: a prospective, randomized, double-blinded trial
- Congress Calendar
- Congress Calendar