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Endogenous Hyperandrogenism and Exercise Capacity Lessons from the Exercise-Congenital Adrenal Hyperplasia Model
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Alon Eliakim
Published/Copyright:
March 2, 2011
ABSTRACT
Athletic excellence requires a combination of genetic endowment, continuous training, appropriate equipment, and proper nutrition. However, the specific genetic and/or intrinsic hormonal milieus that contribute to athletic performance are not clearly understood.
Androgens are thought to play an important role in exercise-induced target tissue response. In adults, the use of exogenous anabolic steroids was found to improve athletic performance, decrease fatigue, increase muscle mass, and increase aggressiveness. However, the benefit of these substances in adolescents remains questionable. Moreover, the role of endogenous androgen secretion for competitive performance success is far less studied.
The present review will summarize aspects related to the effect of endogenous hyperandrogenism on exercise performance, as seen in polycystic ovary syndrome (PCOS), and will concentrate on important lessons learned from the unique model of exercise in congenital adrenal hyperplasia, a disease associated with endogenous hyperandrogenism.
Published Online: 2011-03-02
Published in Print: 2010-December
© Freund Publishing House Ltd. 2010
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Articles in the same Issue
- Congenital Adrenal Hyperplasia (CAH) a Wolf in a Rabbits' Fur
- Endogenous Hyperandrogenism and Exercise Capacity Lessons from the Exercise-Congenital Adrenal Hyperplasia Model
- A Child with Cushing's Syndrome – Etiological Clue from Adrenal Imaging (Pediatric Cushing's Syndrome)
- Polycystic Ovaries and Adrenal Insufficiency in a Young Pubescent Female with Lipoid Congenital Adrenal Hyperplasia Due to Splice Mutation of the StAR Gene: A Case Report and Review of the Literature
- Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic, Physiological, and Environmental Factors on Variations in Fat Deposition and Distribution across Populations
- Application of Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) in Screening of High Risk Children with Inherited Metabolic Diseases in Northern China
- Relationship Between Aminotransferases Levels and Components of the Metabolic Syndrome Among Multiethnic Adolescents
- Etiologies of Precocious Puberty: 15-Year Experience in a Tertiary Hospital in Southern Thailand
- Are IGF-I and IGF-BP3 Useful for Diagnosing Growth Hormone Deficiency in Children of Short Stature?
- Testosterone, Obesity and Insulin Resistance in Young Males: Evidence for an Association between Gonadal Dysfunction and Insulin Resistance During Puberty
- Effects of Vitamin D Receptor Gene Polymorphisms on Susceptibility to Disease and Bone Mineral Density in Turkish Patients with Type 1 Diabetes Mellitus
- Changes in Dynamic Insulin and Gastrointestinal Hormone Secretion in Obese Children
- Risk Factors for Early Onset of Diabetic Nephropathy in Pediatric Type 1 Diabetes
- High Frequency of D727E Polymorphisms in Exon 10 of the TSHR Gene in Brazilian Patients with Congenital Hypothyroidism
- Two Novel Mutations of SRD5A2 Gene in Indonesian Siblings with Clinical 5-Alpha-Reductase Deficiency
- Serendipitous Identification of Graves' Disease in Identical Twins with Polydipsia
- The R450H Mutation and D727E Polymorphism of the Thyrotropin Receptor Gene in a Chinese Child with Congenital Hypothyroidism
- Incidental Finding of Idiopathic Unilateral Adrenal Calcification in an 18-Month-Old Child: Case Report and Review of the Literature
