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Changes in Dynamic Insulin and Gastrointestinal Hormone Secretion in Obese Children
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Christian L. Roth
Published/Copyright:
March 2, 2011
ABSTRACT
Background: Disturbed satiety and hunger perception in obese individuals has been reported, however data on the dynamic changes of hormonal mediators are sparse.
Objective: To evaluate the secretion pattern of insulin, ghrelin, peptide-YY (PYY), and amylin via 0 to 180 min oral glucose tolerance testing in obese and lean children.
Subjects and Methods: A prospective clinical study was conducted on lean (n=9) and obese (n=20) Caucasian children of comparable age, gender, and pubertal stage. Serial blood samples were collected.
Results: Compared to baseline, levels of acylated ghrelin showed a significant decrease in lean (p<0.05) but not in obese children. PYY increase was blunted and of shorter duration (60 min) in obese children. Amylin levels increased in both groups, and attained significantly higher levels in obese children (p<0.05).
Conclusion: Glucose stimulated gut hormone secretion differed between obese and lean children, and may explain the disturbed satiety observed in obese children.
Published Online: 2011-03-02
Published in Print: 2010-December
© Freund Publishing House Ltd. 2010
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Keywords for this article
childhood obesity;
oral glucose tolerance test;
satiety;
gut hormone secretion, insulin
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- A Child with Cushing's Syndrome – Etiological Clue from Adrenal Imaging (Pediatric Cushing's Syndrome)
- Polycystic Ovaries and Adrenal Insufficiency in a Young Pubescent Female with Lipoid Congenital Adrenal Hyperplasia Due to Splice Mutation of the StAR Gene: A Case Report and Review of the Literature
- Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic, Physiological, and Environmental Factors on Variations in Fat Deposition and Distribution across Populations
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