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Are IGF-I and IGF-BP3 Useful for Diagnosing Growth Hormone Deficiency in Children of Short Stature?
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Fiorella Galluzzi
Published/Copyright:
March 2, 2011
ABSTRACT
Background: The diagnosis of growth hormone deficiency (GHD) is based on clinical and auxological characteristics combined with the results of growth hormone provocation tests.
Aim: To evaluate the utility of IGF-I and IGF-BP3 serum levels in the diagnosis of GHD among children of short stature.
Subjects/Methods: We recruited 207 short prepubertal children and divided them into two groups. One group consisted of 70 children (mean age 7.93 ± 2.35SD) with a growth hormone (GH) response on two provocative tests of ≤ 8 ng/ml, while the other group contained 137 children (mean age 7.92 ± 2.11 SD) with a peak GH value of > 8 ng/ml. Serum IGF-1 and IGF-BP3 levels were determined in the two groups.
Results: The difference in serum IGF-I between the two groups was not significant (p=0.26), while the difference in IGF-BP3 between the two groups was statistically significant (p=0.004). The performance of serum IGF-1 and IGF-BP3 as a diagnostic tool, expressed as AUC by ROC analyses, was quite low.
Conclusion: Neither IGF-I nor IGF-BP3 are an adequate substitute for the stimulus test in the diagnosis of growth hormone deficiency among children of short stature.
Published Online: 2011-03-02
Published in Print: 2010-December
© Freund Publishing House Ltd. 2010
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