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Testosterone, Obesity and Insulin Resistance in Young Males: Evidence for an Association between Gonadal Dysfunction and Insulin Resistance During Puberty
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Megan Moriarty-Kelsey
Published/Copyright:
March 2, 2011
ABSTRACT
Objective: To assess the relationships among obesity, insulin sensitivity, and testosterone in pubertal boys.
Participants: This study included 20 lean, obese, and type 2 diabetic (T2DM) males, the majority of whom underwent a hyperinsulinemic-euglycemic clamp (n=16).
Methods: Glucose disposal (M value), serum testosterone, and body mass index (BMI) z-score were measured. Differences in testosterone were evaluated by group (lean vs. obese vs. T2DM), while regression was performed to evaluate the relationships among testosterone, obesity and insulin sensitivity.
Results: Controlling for Tanner stage, testosterone concentration was significantly lower in obese (p=0.02) and T2DM males (p=0.001) compared to lean males. Furthermore, M value was significantly associated with serum testosterone, even after controlling for BMI and Tanner stage.
Conclusions: These data suggest that obese adolescent boys have lower serum testosterone than controls of the same Tanner stage, and echo the data in adult males associating obesity and insulin resistance with hypogonadism.
KEY WORDS: insulin resistance; insulin sensitivity; obesity; hypogonadism; puberty; type 2 diabetes mellitus
Published Online: 2011-03-02
Published in Print: 2010-December
© Freund Publishing House Ltd. 2010
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Keywords for this article
insulin resistance;
insulin sensitivity;
obesity;
hypogonadism;
puberty;
type 2 diabetes mellitus
Articles in the same Issue
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- Endogenous Hyperandrogenism and Exercise Capacity Lessons from the Exercise-Congenital Adrenal Hyperplasia Model
- A Child with Cushing's Syndrome – Etiological Clue from Adrenal Imaging (Pediatric Cushing's Syndrome)
- Polycystic Ovaries and Adrenal Insufficiency in a Young Pubescent Female with Lipoid Congenital Adrenal Hyperplasia Due to Splice Mutation of the StAR Gene: A Case Report and Review of the Literature
- Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic, Physiological, and Environmental Factors on Variations in Fat Deposition and Distribution across Populations
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