The antibacterial and cytocompatibility of the polyurethane nanofibrous scaffold containing curcumin for wound healing applications

Walid Kamal Abdelbasset; Saade Abdalkareem Jasim; Azher M. Abed; Usama S. Altimari; Marwa M. Eid; Yasir Salam Karim; Safaa M. Elkholi; Yasser Fakri Mustafa; Abduladheem Turki Jalil

doi:10.1515/ijmr-2022-0279

Article

The antibacterial and cytocompatibility of the polyurethane nanofibrous scaffold containing curcumin for wound healing applications

Walid Kamal Abdelbasset , Saade Abdalkareem Jasim , Azher M. Abed , Usama S. Altimari , Marwa M. Eid , Yasir Salam Karim , Safaa M. Elkholi , Yasser Fakri Mustafa and Abduladheem Turki Jalil

Published/Copyright: April 5, 2023

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From the journal International Journal of Materials Research Volume 114 Issue 6

Abstract

In today’s world, wound healing is a growing serious problem for clinical institutes. In this study, nanofibrous scaffolds were prepared using polyurethane as a mat scaffold. Also, by immersing curcumin as an antibacterial component another scaffold was fabricated using the electrospinning technique. The obtained scaffolds were characterized by means of scanning electron microscopy, tensile analysis, porosity, and water vapor transmission rate. MTT and DAPI staining were used to prove the biocompatibility and cell attachment of the nanofibers. The curcumin incorporated into the PU scaffold can stop both the Gram-negative and Gram-positive bacteria activities through direct contact with them. Studies showed that the PU/Curcumin scaffold has considerable ability to play a key role in wound healing applications.

Keywords: Antibacterial activity; Nanofibrous scaffold; Wound healing

Corresponding author: Walid Kamal Abdelbasset, Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, P.O. Box. 173, Al-Kharj 11942, Saudi Arabia; and Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza 12613, Egypt, E-mail: walidkamal.wr@gmail.com

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This research was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2022R145), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Competing interest: The authors declare that there is no conflict of interest.

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Received: 2022-06-12

Accepted: 2022-09-25

Published Online: 2023-04-05

Published in Print: 2023-06-27

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Articles in the same Issue

https://doi.org/10.1515/ijmr-2022-0279

Keywords for this article

Antibacterial activity; Nanofibrous scaffold; Wound healing