JMJD3-regulated expression of IL-6 is involved in the proliferation and chemosensitivity of acute myeloid leukemia cells

References

Abdel-Wahab, O. and Levine, R.L. (2013). Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood 121: 3563–3572. https://doi.org/10.1182/blood-2013-01-451781.Search in Google Scholar

Agger, K., Cloos, P.A.C., Rudkjaer, L., Williams, K., Andersen, G., Christensen, J., and Helin, K. (2009). The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 23: 1171–1176. https://doi.org/10.1101/gad.510809.Search in Google Scholar

Amente, S., Lania, L., and Majello, B. (2013). The histone LSD1 demethylase in stemness and cancer transcription programs. Biochim. Biophys. Acta Gene Regul. Mech. 1829: 981–986. https://doi.org/10.1016/j.bbagrm.2013.05.002.Search in Google Scholar

Aoyagi, T., Takishima, K., Hayakawa, M., and Nakamura, H. (1996). Gene expression of TGF-alpha, EGF and IL-6 in cultured renal tubular cells and renal cell carcinoma. Int. J. Urol. 3: 392–396. https://doi.org/10.1111/j.1442-2042.1996.tb00560.x.Search in Google Scholar

Binder, S., Luciano, M., and Horejs-Hoeck, J. (2018). The cytokine network in acute myeloid leukemia (AML): a focus on pro- and anti-inflammatory mediators. Cytokine Growth Factor Rev. 43: 8–15. https://doi.org/10.1016/j.cytogfr.2018.08.004.Search in Google Scholar

Borne, P.A.V., de Wreede, L.C., Halkes, C.J.M., Marijt, W.A.F., Falkenburg, J.H.F., and Veelken, H. (2016). Effectivity of a strategy in elderly AML patients to reach allogeneic stem cell transplantation using intensive chemotherapy: long-term survival is dependent on complete remission after first induction therapy. Leuk. Res. 46: 45–50.10.1016/j.leukres.2016.03.010Search in Google Scholar

Borsellino, N., Bonavida, B., Ciliberto, G., Toniatti, C., Travali, S., and D’Alessandro, N. (1999). Blocking signaling through the gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity. Cancer 85: 134–144. https://doi.org/10.1002/(sici)1097-0142(19990101)85:1<134::aid-cncr19>3.0.co;2-c.10.1002/(SICI)1097-0142(19990101)85:1<134::AID-CNCR19>3.0.CO;2-CSearch in Google Scholar

Bruserud, O. (1998). IL-4, IL-10 and IL-13 in acute myelogenous leukemia. Cytokines Cell Mol. Ther. 4: 187–198.Search in Google Scholar

Burnett, A., Wetzler, M., and Lowenberg, B. (2011). Therapeutic advances in acute myeloid leukemia. J. Clin. Oncol. 29: 487–494. https://doi.org/10.1200/jco.2010.30.1820.Search in Google Scholar

Chen, S.Z., Ma, J., Wu, F.Z., Xiong, L.J., Ma, H.H., Xu, W.Q., Lv, R.T., Li, X.D., Villen, J., Gygi, S.P., et al.. (2012). The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. Genes Dev. 26: 1364–1375. https://doi.org/10.1101/gad.186056.111.Search in Google Scholar

Cloos, P.A.C., Christensen, J., Agger, K., and Helin, K. (2008). Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev. 22: 1115–1140. https://doi.org/10.1101/gad.1652908.Search in Google Scholar

Estey, E.H. (2013). Acute myeloid leukemia: 2013 update on risk-stratification and management. Am. J. Hematol. 88: 318–327. https://doi.org/10.1002/ajh.23404.Search in Google Scholar

Furukawa, M., Ohkawara, H., Ogawa, K., Ikeda, K., Ueda, K., Shichishima-Nakamura, A., Ito, E., Imai, J.I., Yanagisawa, Y., Honma, R., et al.. (2017). Autocrine and paracrine interactions between multiple myeloma cells and bone marrow stromal cells by growth arrest-specific gene 6 cross-talk with interleukin-6. J. Biol. Chem. 292: 4280–4292. https://doi.org/10.1074/jbc.m116.733030.Search in Google Scholar

Gharibi, T., Babaloo, Z., Hosseini, A., Abdollahpour-Alitappeh, M., Hashemi, V., Marofi, F., Nejati, K., and Baradaran, B. (2020). Targeting STAT3 in cancer and autoimmune diseases. Eur. J. Pharmacol. 878: 173107. https://doi.org/10.1016/j.ejphar.2020.173107.Search in Google Scholar

He, C., Sun, J., Liu, C., Jiang, Y., and Hao, Y. (2019). Elevated H3K27me3 levels sensitize osteosarcoma to cisplatin. Clin. Epigenet. 11: 8. https://doi.org/10.1186/s13148-018-0605-x.Search in Google Scholar

Hong, S.H., Cho, Y.W., Yu, L.R., Yu, H., Veenstra, T.D., and Ge, K. (2007). Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc. Natl. Acad. Sci. U.S.A. 104: 18439–18444. https://doi.org/10.1073/pnas.0707292104.Search in Google Scholar

Hui, R.C., Francis, R.E., Guest, S.K., Costa, J.R., Gomes, A.R., Myatt, S.S., Brosens, J.J., and Lam, E.W. (2008). Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells. Mol. Canc. Therapeut. 7: 670–678. https://doi.org/10.1158/1535-7163.mct-07-0397.Search in Google Scholar

Johnson, D.E., O’Keefe, R.A., and Grandis, J.R. (2018). Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat. Rev. Clin. Oncol. 15: 234–248. https://doi.org/10.1038/nrclinonc.2018.8.Search in Google Scholar

Kanno, S.I., Hiura, T., Ohtake, T., Koiwai, K., Suzuki, H., Ujibe, M., and Ishikawa, M. (2007). Characterization of resistance to cytosine arabinoside (Ara-C) in NALM-6 human B leukemia cells. Clin. Chim. Acta 377: 144–149. https://doi.org/10.1016/j.cca.2006.09.014.Search in Google Scholar

Kinoshita, T., Ito, H., and Miki, C. (1999). Serum interleukin-6 level reflects the tumor proliferative activity in patients with colorectal carcinoma. Cancer 85: 2526–2531. https://doi.org/10.1002/(sici)1097-0142(19990615)85:12<2526::aid-cncr6>3.0.co;2-3.10.1002/(SICI)1097-0142(19990615)85:12<2526::AID-CNCR6>3.0.CO;2-3Search in Google Scholar

Lamble, A.J. and Lind, E.F. (2018). Targeting the immune microenvironment in acute myeloid leukemia: a focus on T cell immunity. Front. Oncol. 8: 213. https://doi.org/10.3389/fonc.2018.00213.Search in Google Scholar

Lee, K., Na, W., Lee, J.Y., Na, J., Cho, H., Wu, H., Yune, T.Y., Kim, W.S., and Ju, B.G. (2012). Molecular mechanism of Jmjd3-mediated interleukin-6 gene regulation in endothelial cells underlying spinal cord injury. J. Neurochem. 122: 272–282. https://doi.org/10.1111/j.1471-4159.2012.07786.x.Search in Google Scholar

Li, P., Ji, M., Park, J., Bunting, K.D., Ji, C., and Tse, W. (2012). Th17 related cytokines in acute myeloid leukemia. Front. Biosci. 17: 2284–2294. https://doi.org/10.2741/4052.Search in Google Scholar

Liang, M., Han, X., Fernandez, M., Nguyen, M., Rassidakis, G.Z., Drakos, I., Medeiros, L.J., and Bueso-Ramos, C.E. (2008). Analysis of HDM4 expression, a key regulator of p53, in B-cell non-hodgkin lymphomas: the HDM4-S splice mRNA variant is aberrantly overexpressed in mantle cell lymphoma. Mod. Pathol. 21: 263a.Search in Google Scholar

Matthes, T., Manfroi, B., Zeller, A., Dunand-Sauthier, I., Bogen, B., and Huard, B. (2015). Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow. Leukemia 29: 1882–1890. https://doi.org/10.1038/leu.2015.145.Search in Google Scholar

Megias-Vericat, J.E., Martinez-Cuadron, D., Sanz, M.A., Poveda, J.L., and Montesinos, P. (2019). Daunorubicin and cytarabine for certain types of poor-prognosis acute myeloid leukemia: a systematic literature review. Expet Rev. Clin. Pharmacol. 12: 197–218. https://doi.org/10.1080/17512433.2019.1573668.Search in Google Scholar

Naruishi, K. and Nagata, T. (2018). Biological effects of interleukin-6 on gingival fibroblasts: cytokine regulation in periodontitis. J. Cell. Physiol. 233: 6393–6400. https://doi.org/10.1002/jcp.26521.Search in Google Scholar

Oben, K.Z., Alhakeem, S.S., McKenna, M.K., Brandon, J.A., Mani, R., Noothi, S.K., Jinpeng, L., Akunuru, S., Dhar, S.K., Singh, I.P., et al.. (2017). Oxidative stress-induced JNK/AP-1 signaling is a major pathway involved in selective apoptosis of myelodysplastic syndrome cells by Withaferin-A. Oncotarget 8: 77436–77452. https://doi.org/10.18632/oncotarget.20497.Search in Google Scholar

Park, H.H., Kim, M., Lee, B.H., Lim, J., Kim, Y., Lee, E.J., Min, W.S., Kang, C.S., Kim, W.I., Shim, S.I., et al.. (2006). Intracellular IL-4, IL-10, and IFN-γ levels of leukemic cells and bone marrow T cells in acute leukemia. Ann. Clin. Lab. Sci. 36: 7–15.Search in Google Scholar

Reynaud, D., Pietras, E., Barry-Holson, K., Mir, A., Binnewies, M., Jeanne, M., Sala-Torra, O., Radich, J.P., and Passegue, E. (2011). IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Canc. Cell 20: 661–673. https://doi.org/10.1016/j.ccr.2011.10.012.Search in Google Scholar

Sanchez-Correa, B., Bergua, J.M., Campos, C., Gayoso, I., Arcos, M.J., Banas, H., Morgado, S., Casado, J.G., Solana, R., and Tarazona, R. (2013). Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. Cytokine 61: 885–891. https://doi.org/10.1016/j.cyto.2012.12.023.Search in Google Scholar

Shi, Y. (2007). Histone lysine demethylases: emerging roles in development, physiology and disease. Nat. Rev. Genet. 8: 829–833. https://doi.org/10.1038/nrg2218.Search in Google Scholar

Shi, Z., Tiwari, A.K., Patel, A.S., Fu, L.W., and Chen, Z.S. (2011). Roles of sildenafil in enhancing drug sensitivity in cancer. Canc. Res. 71: 3735–3738. https://doi.org/10.1158/0008-5472.can-11-0375.Search in Google Scholar

Soriano, A.A., de Cristofaro, T., Di Palma, T., Dotolo, S., Gokulnath, P., Izzo, A., Cali, G., Facchiano, A., and Zannini, M. (2019). PAX8 expression in high-grade serous ovarian cancer positively regulates attachment to ECM via integrin β3. Canc. Cell Int. 19: 303. https://doi.org/10.1186/s12935-019-1022-8.Search in Google Scholar

Stevens, A.M., Miller, J.M., Munoz, J.O., Gaikwad, A.S., and Redell, M.S. (2017). Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance. Blood Adv. 1: 1387–1397. https://doi.org/10.1182/bloodadvances.2017007856.Search in Google Scholar

Wang, J., Jiang, S., Kwong, J.M., Sanchez, R.N., Sadun, A.A., and Lam, T.T. (2006). Nuclear factor-kappaB p65 and upregulation of interleukin-6 in retinal ischemia/reperfusion injury in rats. Brain Res. 1081: 211–218. https://doi.org/10.1016/j.brainres.2006.01.077.Search in Google Scholar

Wang, J., Song, T., Zhou, S., and Kong, X. (2019). YAP promotes the malignancy of endometrial cancer cells via regulation of IL-6 and IL-11. Mol. Med. 25: 32. https://doi.org/10.1186/s10020-019-0103-4.Search in Google Scholar

Wang, R., Wang, W., Xu, J., Liu, D., Jiang, H., and Pan, F. (2018). Dynamic effects of early adolescent stress on depressive-like behaviors and expression of cytokines and JMJD3 in the prefrontal cortex and Hippocampus of rats. Front. Psychiatr. 9: 471. https://doi.org/10.3389/fpsyt.2018.00471.Search in Google Scholar

Williams, K., Christensen, J., Rappsilber, J., Nielsen, A.L., Johansen, J.V., and Helin, K. (2014). The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner. PloS One 9: e96545. https://doi.org/10.1371/journal.pone.0096545.Search in Google Scholar

Xiang, Y., Zhu, Z.Q., Han, G., Lin, H.Q., Xu, L.Y., and Chen, C.D. (2007). JMJD3 is a histone H3K27 demethylase. Cell Res. 17: 850–857. https://doi.org/10.1038/cr.2007.83.Search in Google Scholar

Xu, Z.Y., Xia, Y.B., Xiao, Z.G., Jia, Y.L., Li, L., Jin, Y., Zhao, Q.J., Wan, L., Yi, T., Yu, Y.T., et al.. (2019). Comprehensive profiling of JMJD3 in gastric cancer and its influence on patient survival. Sci. Rep. 9: 868. https://doi.org/10.1038/s41598-018-37340-w.Search in Google Scholar

Ye, R.D. and Sun, L. (2015). Emerging functions of serum amyloid A in inflammation. J. Leukoc. Biol. 98: 923–929. https://doi.org/10.1189/jlb.3vmr0315-080r.Search in Google Scholar

Yu, S.H., Zhu, K.Y., Chen, J., Liu, X.Z., Xu, P.F., Zhang, W., Yan, L., Guo, H.Z., and Zhu, J. (2018). JMJD3 facilitates C/EBP beta-centered transcriptional program to exert oncorepressor activity in AML. Nat. Commun. 9: 3369. https://doi.org/10.1038/s41467-018-05548-z.Search in Google Scholar

Zhang, W., Cheng, J., Diao, P., Wang, D., Zhang, W., Jiang, H., and Wang, Y. (2020). Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1. Br. J. Canc. 122: 528–538. https://doi.org/10.1038/s41416-019-0680-6.Search in Google Scholar

Zhang, Y., Hua, P.Y., Jin, C.Y., Li, J.D., Zhang, G.X., and Wang, B. (2019). JMJD3 enhances invasiveness and migratory capacity of non-small cell lung cancer cell via activating EMT signaling pathway. Eur. Rev. Med. Pharmacol. Sci. 23: 4784–4792. https://doi.org/10.26355/eurrev_201906_18063.Search in Google Scholar

Zou, S., Zhang, D.C., Xu, Z.W., Wen, X.C., and Zhang, Y. (2019). JMJD3 promotes the epithelial-mesenchymal transition and migration of glioma cells via the CXCL12/CXCR4 axis. Oncol. Lett. 18: 5930–5940. https://doi.org/10.3892/ol.2019.10972.Search in Google Scholar