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IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1

  • Tie Lin , Dongpeng Wang , Jun Chen , Zhan Zhang , Yuming Zhao , Zhong Wu and Yuehua Wang ORCID logo EMAIL logo
Published/Copyright: April 26, 2021
Biological Chemistry
From the journal Biological Chemistry Volume 402 Issue 7

Abstract

Glioblastoma (GBM) is the most common and fatal type of primary malignant tumours in the central nervous system. Cytokines such as interleukins (ILs) play an important role in GBM progression. Our present study found that IL-24 is down-regulated in GBM cells. Recombinant IL-24 (rIL-24) can suppress the in vitro migration and invasion of GBM cells while increase its chemo-sensitivity to temozolomide (TMZ) treatment. rIL-24 negatively regulates the expression of Zeb1, one well known transcription factors of epithelial to mesenchymal transition (EMT) of cancer cells. Over expression of Zeb1 can attenuate IL-24-suppressed malignancy of GBM cells. Mechanistically, IL-24 decreases the protein stability of Zeb1 while has no effect on its mRNA stability. It is due to that IL-24 can increase the expression of FBXO45, which can destabilize Zeb1 in cancer cells. Collectively, we reveal that IL-24 can suppress the malignancy of GBM cells via decreasing the expression of Zeb1. It suggests that targeted activation of IL-24 signals might be a potential therapy approach for GBM treatment.

Keywords: FBXO45; glioblastoma; IL-24; malignancy; Zeb1
Corresponding author: Yuehua Wang, Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin150001, People’s Republic of China, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflict of interest.

  4. Ethics approval and consent to participate: Informed consent was obtained from all individual participants included in the study.

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Received: 2020-11-22
Accepted: 2021-04-15
Published Online: 2021-04-26
Published in Print: 2021-06-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Research Articles/Short Communications
  3. Protein Structure and Function
  4. Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase
  5. Molecular Medicine
  6. Elucidating the anti-biofilm and anti-quorum sensing potential of selenocystine against respiratory tract infections causing bacteria: in vitro and in silico studies
  7. Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress
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  10. Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway
  11. JMJD3-regulated expression of IL-6 is involved in the proliferation and chemosensitivity of acute myeloid leukemia cells
  12. Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols
  13. IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1
  14. Glycation of benign meningioma cells leads to increased invasion
  15. Proteolysis
  16. Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
https://doi.org/10.1515/hsz-2020-0373
Keywords for this article
FBXO45; glioblastoma; IL-24; malignancy; Zeb1

Articles in the same Issue

  1. Frontmatter
  2. Research Articles/Short Communications
  3. Protein Structure and Function
  4. Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase
  5. Molecular Medicine
  6. Elucidating the anti-biofilm and anti-quorum sensing potential of selenocystine against respiratory tract infections causing bacteria: in vitro and in silico studies
  7. Carotenoids in Sporidiobolus pararoseus ameliorate diabetic nephropathy in mice through attenuating oxidative stress
  8. Cell Biology and Signaling
  9. Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function
  10. Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway
  11. JMJD3-regulated expression of IL-6 is involved in the proliferation and chemosensitivity of acute myeloid leukemia cells
  12. Modulation of recombinant human alpha 1 glycine receptor by flavonoids and gingerols
  13. IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1
  14. Glycation of benign meningioma cells leads to increased invasion
  15. Proteolysis
  16. Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins
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