Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population

Jalaledin Mirzay Razzaz; Hossein Moameri; Zahra Akbarzadeh; Mohammad Ariya; Seyed ali Hosseini; Alireza Ghaemi; Saeed Osati; Elham Ehrampoush; Reza Homayounfar

doi:10.1515/hmbci-2020-0084

Article

Investigating the relationship between insulin resistance and adipose tissue in a randomized Tehrani population

Jalaledin Mirzay Razzaz , Hossein Moameri , Zahra Akbarzadeh , Mohammad Ariya , Seyed ali Hosseini , Alireza Ghaemi , Saeed Osati , Elham Ehrampoush and Reza Homayounfar

Published/Copyright: March 15, 2021

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From the journal Hormone Molecular Biology and Clinical Investigation Volume 42 Issue 3

Abstract

Objectives

Insulin resistance is the most common metabolic change associated with obesity. The present study aimed to investigate the relationship between insulin resistance and body composition especially adipose tissue in a randomized Tehrani population.

Methods

This study used data of 2,160 individuals registered in a cross-sectional study on were randomly selected from among subjects who were referred to nutrition counseling clinic in Tehran, from April 2016 to September 2017. Insulin resistance was calculated by homeostasis model assessment formula. The odds ratio (95% CI) was calculated using logistic regression models.

Results

The mean age of the men was 39 (±10) and women were 41 (±11) (the age ranged from 20 to 50 years). The risk of increased HOMA-IR was 1.03 (95% CI: 1.01–1.04) for an increase in one percent of Body fat, and 1.03 (95% CI: 1.00–1.05) for an increase in one percent of Trunk fat. Moreover, the odds ratio of FBS for an increase in one unit of Body fat percent and Trunk fat percent increased by 1.05 (adjusted odds ratio [95% CI: 1.03, 1.06]) and 1.05 (95% CI: 1.02, 1.08). Also, the risk of increased Fasting Insulin was 1.05 (95% CI: 1.03–1.07) for an increase in one unit of Body fat percent, and 1.05 (95% CI: 1.02–1.08) for an increase in one unit of Trunk fat percent.

Conclusions

The findings of the present study showed that there was a significant relationship between HOMA-IR, Fasting blood sugar, Fasting Insulin, and 2 h Insulin with percent of Body fat, percent of Trunk fat.

Keywords: abdominal obesity; adipose tissue; HOMA-IR; insulin resistance

Corresponding author: Reza Homayounfar, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran, Phone: +989368078899, E-mail: r_homayounfar@yahoo.com

Funding source: Fasa University of Medical Sciences

Award Identifier / Grant number: 97192

Acknowledgments

Hereby, the authors thank the institute for its full support and extend their thanks to all study participants for their collaboration.

Research funding: This study was funded and supported by the Fasa University of Medical Sciences (Grant no. 97192).
Author contributions: Study concept and design: RH, EE; Analysis and interpretation of data: RH, HM; Acquisition of data: AG, SO, RH, MA; Drafting of the manuscript: AG, SH, RH, ZA; Statistical analysis: RH, HM, AG; Obtained funding: RH; Administrative, technical, or material support: RH; Study supervision: RH.
Competing interests: The authors declare that they have no competing interests.
Informed consent: The participants were informed about the research objectives and written informed consent was obtained from the subjects before starting the survey.
Ethical approval: The study protocol was following the Helsinki Declaration and confirmed by the Ethics Committee of Fasa University of Medical Sciences (Approval Code: IR.FUMS.REC.1398.094).

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Received: 2020-12-02

Accepted: 2021-02-18

Published Online: 2021-03-15

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Articles in the same Issue

https://doi.org/10.1515/hmbci-2020-0084

Keywords for this article

abdominal obesity; adipose tissue; HOMA-IR; insulin resistance